Liposomes useful for drug delivery
First Claim
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1. A liposomal irinotecan composition comprising liposomes in a an aqueous medium, the liposomes having an interior aqueous space separated from the aqueous medium by a membrane, said membrane comprising lipids, said lipids comprising an uncharged lipid component and a neutral phospholipid, with, entrapped inside the liposomes:
- 1) irinotecan and sucrose octasulfate, or2) irinotecan and sucrose octasulfate and a substituted ammonium compound,wherein, when administered into the bloodstream of a mammal, said irinotecan has a half-release time from said liposomes of at least 24 hours and the irinotecan entrapped inside the liposomes is at a concentration that exceeds the irinotecan concentration in the aqueous medium.
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Abstract
The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention.
83 Citations
35 Claims
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1. A liposomal irinotecan composition comprising liposomes in a an aqueous medium, the liposomes having an interior aqueous space separated from the aqueous medium by a membrane, said membrane comprising lipids, said lipids comprising an uncharged lipid component and a neutral phospholipid, with, entrapped inside the liposomes:
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1) irinotecan and sucrose octasulfate, or 2) irinotecan and sucrose octasulfate and a substituted ammonium compound, wherein, when administered into the bloodstream of a mammal, said irinotecan has a half-release time from said liposomes of at least 24 hours and the irinotecan entrapped inside the liposomes is at a concentration that exceeds the irinotecan concentration in the aqueous medium. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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Specification