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Liposomes useful for drug delivery

  • US 8,147,867 B2
  • Filed: 05/02/2005
  • Issued: 04/03/2012
  • Est. Priority Date: 05/03/2004
  • Status: Active Grant
First Claim
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1. A liposomal irinotecan composition comprising liposomes in a an aqueous medium, the liposomes having an interior aqueous space separated from the aqueous medium by a membrane, said membrane comprising lipids, said lipids comprising an uncharged lipid component and a neutral phospholipid, with, entrapped inside the liposomes:

  • 1) irinotecan and sucrose octasulfate, or2) irinotecan and sucrose octasulfate and a substituted ammonium compound,wherein, when administered into the bloodstream of a mammal, said irinotecan has a half-release time from said liposomes of at least 24 hours and the irinotecan entrapped inside the liposomes is at a concentration that exceeds the irinotecan concentration in the aqueous medium.

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