Compositions and methods for mediating RNAi in vivo
First Claim
Patent Images
1. A formulated lipid particle (FLiP) comprising:
- (a) a double stranded oligonucleotide conjugated to a lipophile, and(b) a 20% intravenous fat emulsion to which the lipophile-conjugated double stranded oligonucleotide is associated.
2 Assignments
0 Petitions
Accused Products
Abstract
This invention relates to new formulated lipid particles (FLiPs) comprising at least one of a single or double stranded oligonucleotide, where the oligonucleotide has been conjugated to a lipophile and at least one of an emulsion or liposome to which the conjugated oligonucleotide has been aggregated, admixed or associated. These particles have surprisingly been shown to effectively deliver oligonucleotides to heart, lung and muscle where they effect gene silencing.
-
Citations
25 Claims
-
1. A formulated lipid particle (FLiP) comprising:
-
(a) a double stranded oligonucleotide conjugated to a lipophile, and (b) a 20% intravenous fat emulsion to which the lipophile-conjugated double stranded oligonucleotide is associated. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
-
Specification