High-resolution parametric signal restoration

• US 8,149,041 B2
• Filed: 04/04/2011
• Issued: 04/03/2012
• Est. Priority Date: 08/08/2008
• Status: Active Grant

• Current Assignee: Beckman Coulter Incorporated (Danaher Corporation)
• Original Assignee: Beckman Coulter Incorporated (Danaher Corporation)
• Inventors: Quesada, Valentin T., Weber, Bruce M.
• Primary Examiner(s): Wells, Kenneth B.
• Application Number:
  US13/079,504
• Publication Number:
  US 20110175661A1
• Time in Patent Office: 365 Days
• Field of Search: 327/307, 330/9
• US Class Current: 327/307
• CPC Class Codes: G01N 15/00 Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials identification of microorganisms C12Q
• CPC Class Codes: G01N 15/1429 Signal processing
• CPC Class Codes: G01N 15/1459 the analysis being performed on a sample stream
• CPC Class Codes: G01N 2015/1477 Multiparameters

Abstract

Provided are high-resolution parametric signal restoration systems, and applications thereof. Such systems include a multi-output module and a parametric compensator. The multi-output module provides a reference gain output signal and one or more higher gain output signals based on a single input signal. The parametric compensator independently responds to functional parameters of the one or more higher gain output signals to provide a compensation error signal. The single input signal is modified based on the compensation error signal.

Claims

1. A system comprising:

an input signal modifier configured to generate a modified input signal from a received input signal;

a multiple-gain device, the multiple-gain device comprising;

a first amplifier configured to provide a first output signal derived from the modified input signal, and

a second amplifier configured to provide a second output signal derived from the modified input signal, the second amplifier being configured to produce a relatively larger gain than the first amplifier; and

a pulse undershoot module configured to provide a pulse undershoot recovery signal, the pulse undershoot recovery signal being used to offset any AC voltage buildup prior to generation of subsequent modified input signals, and

an adaptive response controller configured to derive a compensation signal from the second output signal and to transmit the compensation signal to the multiple-gain device.

2. The system of claim 1, wherein the pulse undershoot module is configured to reduce a pulse undershoot recovery time between first and second pulses of the modified input signal before transmitting the pulse undershoot recovery signal to the input modifier.

3. The system of claim 1, wherein the adaptive response controller is configured to perform the deriving of the compensation signal based on at least one of a thermal drift, signal noise, and DC offsets of at least one of the first and second amplifiers.

4. A system comprising:

an input signal modifier configured to generate a modified input signal from a received input signal;

a first amplifier configured to provide a first output signal derived from the modified input signal, and

a second amplifier configured to provide a second output signal derived from the modified input signal, the second amplifier being configured to produce a relatively larger gain than the first amplifier; and

a pulse undershoot module configured to provide a pulse undershoot recovery signal, the pulse undershoot recovery signal being used to offset any AC voltage buildup prior to generation of subsequent ones of the modified input signal, and

an adaptive response controller configured to derive a compensation signal from the second output signal and to transmit the compensation signal to the multiple-gain device,

wherein the input modifier comprises;

a first filter configured to filter the input signal;

an AC coupling coupled to the first filter and the pulse undershoot module;

a summer coupled to the AC coupling; and

a second filter coupled between the summer and the first and second amplifiers and configured to produce the modified input signal.

5. A system comprising:

an input signal modifier configured to generate a modified input signal from a received input signal;

a first amplifier configured to provide a first output signal derived from the modified input signal, and

a second amplifier configured to provide a second output signal derived from the modified input signal, the second amplifier being configured to produce a relatively larger gain than the first amplifier; and

a pulse undershoot module configured to derive a pulse undershoot recovery signal, the pulse undershoot recovery signal being used to offset any AC voltage buildup prior to generation of subsequent ones of the modified input signal, and

an adaptive response controller configured to derive a compensation signal from the second output signal and to transmit the compensation signal to the multiple-gain device,

wherein the pulse undershoot module comprises;

a pulse undershoot recovery regulator; and

a pulse undershoot recoverer coupled between the pulse undershoot recovery regulator and the input modifier.

6. A system comprising:

an input signal modifier configured to generate a modified input signal from a received input signal;

a first amplifier configured to provide a first output signal derived from the modified input signal;

a second amplifier configured to provide a second output signal derived from the modified input signal, the second amplifier being configured to produce a relatively larger gain than the first amplifier;

a pulse undershoot module configured to derive a pulse undershoot recovery signal, the pulse undershoot recovery signal being used to offset any AC voltage buildup prior to generation of subsequent ones of the modified input signal; and

an adaptive response controller configured to derive a compensation signal from the second output signal and to transmit the compensation signal to the multiple-gain device,

wherein the adaptive response controller comprises;

an adaptive response filter coupled to at least one of the first and second amplifiers;

a bias operating point module coupled to the adaptive response filter;

a first proportional offset coupled between the bias operation point module and the first amplifier; and

a second proportional offset coupled between the bias operation point module and the second amplifier.

7. The system of claim 6, wherein the adaptive response controller further comprises a programmable offset controller.

8. A system comprising:

an input signal modifier configured to generate a modified input signal from a received input signal;

a first amplifier configured to provide a first output signal derived from the modified input signal, and

a second amplifier configured to provide a second output signal derived from the modified input signal, the second amplifier being configured to produce a relatively larger gain than the first amplifier;

a pulse undershoot module configured to derive a pulse undershoot recovery signal, the pulse undershoot recovery signal being used to offset any AC voltage buildup prior to generation of subsequent ones of the modified input signal;

an adaptive response controller configured to derive a compensation signal from the second output signal and to transmit the compensation signal to the multiple-gain device; and

a bypass configured to provide a restoration bypass function used to determine channel and sensor offsets during initialization and system calibration.

9. A system, comprising:

an AC coupling;

a first amplifier having a first gain and configured to produce a first amplified signal based on an input signal received via the AC coupling;

a second amplifier having a second gain, which is different from the first gain, and configured to produce a second amplified signal based on the input signal received via the AC coupling;

a pulse undershoot module coupled to the AC coupling and configured to reduce an amplitude and time duration of pulse undershoot during recovery of the input signal;

an adaptive response control module configured to generate a compensation error signal based on the second amplified signal; and

a summation module configured to add the compensation error signal to the input signal.

10. The system of claim 9, wherein the pulse undershoot module comprises:

a pulse undershoot recoverer configured to rectify the input signal to provide baseline recovery; and

a pulse undershoot recovery regulator configured to provide a compensation offset voltage to the pulse undershoot recovery circuit to reduce an offset of the pulse undershoot recoverer.

11. The system of claim 10, wherein the pulse undershoot recovery regulator comprises a microprocessor configured to use feedback to control the compensation offset voltage.

12. The system of claim 10, wherein the pulse undershoot recovery regulator comprises a feedback element configured to monitor an input offset voltage of the pulse undershoot recovery circuit and provide the compensation offset voltage based on the input offset voltage.

13. The system of claim 10, wherein the pulse undershoot recovery regulator comprises an adjuster circuit configured to provide the compensation offset voltage responsive to an input.

14. The system of claim 10, wherein the pulse undershoot recovery regulator comprises an element configured to provide a substantially fixed-value compensation offset voltage.

15. The system of claim 9, wherein the adaptive response control module comprises a bias operating point module configured to shift a DC operating level of the first and second amplifiers.

16. The system of claim 9, wherein the adaptive response control module comprises a programmable offset control configured to shift a DC operating level of the first and second amplifiers based on input received via a system interface.

17. The system of claim 9, wherein the adaptive response control module comprises:

a first proportional offset configured to provide a first proportion of the compensation error signal to the first amplifier; and

a second proportional offset configured to provide a second proportion of the compensation error signal to the second amplifier.

18. The system of claim 9, wherein the adaptive response control module comprises:

an adaptive response filter; and

a bias operating point module configured to reduce a DC operating level of the first and second amplifier to reduce an average noise above ground.

19. The system of claim 9, wherein the adaptive response control module comprises:

an adaptive response filter; and

a bias operating point module configured to respond to noise levels or thermal offset changes from the second amplifier to adjust a DC operating level of the first and second amplifiers.

20. A method comprising:

generating a modified input signal from an input signal;

generating a first output signal, based on the modified input signal, the first output signal having a first gain;

generating a second output signal, based on the modified input signal, the second output signal having a second gain that is larger than the first gain;

determining a pulse undershoot recovery signal that reduces a pulse undershoot recovery time between first and second pulses of the modified input signal, the pulse undershoot recovery signal being used during subsequent performing of the generating of the modified input signal; and

determining a compensation signal from the second output signal based on at least one of a thermal drift, signal noise, and DC offsets, the compensation signal being used during subsequent performing of the generating the first and second output signals.