Renal nerve stimulation method and apparatus for treatment of patients
First Claim
Patent Images
1. A method of treating a disease of a human patient diagnosed with at least one of heart failure, hypertension, acute myocardial infarction, impaired renal function, or chronic renal failure, the method of treating the patient comprising:
- positioning an energy delivery element proximate to a renal nerve of the patient; and
delivering an energy field via the energy delivery element to modulate neural function of the renal nerve,wherein delivering the energy field results in a therapeutically beneficial reduction in blood pressure of the patient.
5 Assignments
0 Petitions
Reexamination
Accused Products
Abstract
A method and apparatus for treatment of heart failure, hypertension and renal failure by stimulating the renal nerve. The goal of therapy is to reduce sympathetic activity of the renal nerve. Therapy is accomplished by at least partially blocking the nerve with drug infusion or electrostimulation. Apparatus can be permanently implanted or catheter based.
-
Citations
62 Claims
-
1. A method of treating a disease of a human patient diagnosed with at least one of heart failure, hypertension, acute myocardial infarction, impaired renal function, or chronic renal failure, the method of treating the patient comprising:
-
positioning an energy delivery element proximate to a renal nerve of the patient; and delivering an energy field via the energy delivery element to modulate neural function of the renal nerve, wherein delivering the energy field results in a therapeutically beneficial reduction in blood pressure of the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
-
-
14. A method of treating a disease of a human patient diagnosed with at least one of heart failure, hypertension, acute myocardial infarction, impaired renal function, or chronic renal failure, the method of treating the patient comprising:
-
delivering a device to a vicinity of a post-ganglionic neural fiber that innervates a kidney of the patient; and thermally inducing modulation of a function of the neural fiber with the device wherein thermally inducing modulation significantly improves a measureable physiological parameter corresponding to the disease of the patient. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22)
-
-
23. A method of treating a human patient diagnosed with a condition associated with central sympathetic overactivity, the method of treating the patient comprising:
-
introducing a modulation instrument proximate to a post-ganglionic neural fiber that innervates a kidney of the patient; and reducing sympathetic neural activity in the patient by delivering energy to the neural fiber via the modulation instrument in order to modulate a function of the neural fiber, wherein reducing sympathetic neural activity results in a therapeutically beneficial reduction in blood pressure in the patient. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
-
-
37. A method of treating a disease of a human patient diagnosed with at least one of heart failure, hypertension, acute myocardial infarction, impaired renal function, proteinuria or chronic renal failure, the method of treating the patient comprising:
-
positioning an energy transfer element at least proximate to a neural fiber that innervates a kidney of the patient; and transferring energy via the energy transfer element in a manner that at least partially ablates the neural fiber, wherein at least partially ablating the neural fiber results in a significant reduction in blood pressure of the patient. - View Dependent Claims (38, 39)
-
-
40. A method for treating a disease of a human patient diagnosed with at least one of heart failure, hypertension, acute myocardial infarction, impaired renal function, or chronic renal failure, the method for treating the patient comprising:
-
positioning a modulation device proximate to a first renal nerve corresponding to a first kidney of the patient; positioning the modulation device proximate to a second renal nerve corresponding to a second kidney of the patient; and delivering an energy field via the modulation device to modulate neural function of the first renal nerve and the second renal nerve, wherein delivering the energy field significantly improves a measureable physiological parameter corresponding to the disease of the patient.
-
-
41. A method of treating a disease of a human patient diagnosed with at least one of heart failure, hypertension, acute myocardial infarction, impaired renal function, or chronic renal failure, the method of treating the patient comprising:
-
positioning an energy transfer device in a vicinity of post-ganglionic neural fibers that innervate a kidney of the patient; and thermally modulating a function of the neural fibers with the device, wherein thermally modulating the function of the neural fibers results in a therapeutically beneficial reduction in blood pressure of the patient. - View Dependent Claims (42, 43, 44, 45, 46, 47, 48, 49, 50)
-
-
51. A method of treating a disease of a human patient associated with central sympathetic overactivity, the method comprising:
-
introducing a modulation instrument proximate to a post-ganglionic neural fiber that innervates a kidney of the patient; and reducing afferent and/or efferent renal neural activity in the patient by delivering energy to the neural fiber via the modulation instrument, wherein reducing afferent and/or efferent renal neural activity significantly improves a measureable physiological parameter corresponding to the disease of the patient. - View Dependent Claims (52, 53, 54, 55, 56)
-
-
57. A method of renal denervation for treating a disease of a human patient diagnosed with at least one of heart failure, hypertension, acute myocardial infarction, impaired renal function, or chronic renal failure, the method of renal denervation for treating the patient comprising:
-
positioning an energy delivery element proximate to a renal nerve of the patient; and delivering an energy field via the energy delivery element to modulate neural function of the renal nerve, wherein delivering the energy field significantly improves a measureable physiological parameter corresponding to the disease of the patient.
-
-
58. A method of treating a disease of a human patient diagnosed with at least one of heart failure, hypertension, acute myocardial infarction, impaired renal function, or chronic renal failure via renal denervation, the method of treating the patient comprising:
-
positioning an energy delivery element proximate to a renal nerve of the patient; and delivering an energy field via the energy delivery element to modulate neural function of the renal nerve, wherein delivering the energy field results in a therapeutically beneficial reduction in central sympathetic overactivity in the patient.
-
-
59. A method of treating a disease of a human patient diagnosed with at least one of heart failure, hypertension, acute myocardial infarction, impaired renal function, or chronic renal failure, the method of treating the patient comprising:
-
delivering a device to a vicinity of a post-ganglionic neural fiber that innervates a kidney of the patient; and thermally inducing modulation of a function of the neural fiber with the device, wherein thermally inducing modulation results in a therapeutically beneficial reduction in blood pressure of the patient.
-
-
60. A method of treating a disease of a human patient diagnosed with at least one of heart failure, hypertension, acute myocardial infarction, impaired renal function, or chronic renal failure, the method of treating the patient comprising:
-
delivering a device to afferent and efferent neural fibers corresponding to a kidney of the patient; and thermally reducing neural communication along the neural fibers with the device, wherein thermally reducing neural communication along the neural fibers results in a therapeutically beneficial reduction in central sympathetic overactivity in the patient.
-
-
61. A method of treating a human patient diagnosed with a condition associated with central sympathetic overstimulation, the method of treating the patient comprising:
-
introducing a modulation instrument proximate to a post-ganglionic neural fiber that innervates a kidney of the patient; and reducing sympathetic neural activity in the patient by delivering energy to the neural fiber via the modulation instrument to modulate a function of the neural fiber, wherein reducing sympathetic neural activity results in a therapeutically beneficial reduction in blood pressure of the patient.
-
-
62. A method of treating a human patient diagnosed with a condition associated with central sympathetic overstimulation, the method of treating the patient comprising:
-
introducing a modulation instrument proximate to a post-ganglionic neural fiber that innervates a kidney of the patient; and reducing sympathetic neural activity in the patient by delivering energy to the neural fiber via the modulation instrument to modulate a function of the neural fiber, wherein reducing sympathetic neural activity significantly improves a measureable physiological parameter corresponding to the disease of the patient.
-
Specification