Chip-holder for a micro-fluidic chip

• US 8,153,059 B2
• Filed: 07/25/2005
• Issued: 04/10/2012
• Est. Priority Date: 07/25/2005
• Status: Expired due to Fees

• Current Assignee: Fraunhofer Gesellschaft Zur Foerderung Der Angewandten Forsching E.V.
• Original Assignee: Fraunhofer Gesellschaft Zur Foerderung Der Angewandten Forsching E.V.
• Inventors: Trieu, Hoc Khiem, Bollerott, Michael, Hildebrand, Robert, Van Hest, Jan, Koch, Kaspar, Nieuwland, Pieter, Van Beek, Teris A., Boom, Remko M., Rutjes, Floris, Kemmerling, Martin, Sudhölter, Ernst J. R., Janssen, Anja E. M.
• Primary Examiner(s): Bullock, In Suk
• Assistant Examiner(s): Pregler, Sharon
• Application Number:
  US11/996,627
• Publication Number:
  US 20080299013A1
• Time in Patent Office: 2,451 Days
• Field of Search: 422/50, 422/55, 422/60, 422/61, 422/62, 422/63, 422/68.1, 422/82.05, 422/122, 422500-508, 435/288, 435/291, 435/316, 435/803, 435/810
• US Class Current: 422/50
• CPC Class Codes: B01L 2200/027 for microfluidic devices
• CPC Class Codes: B01L 2300/021 Identification, e.g. bar codes
• CPC Class Codes: B01L 2300/022 Transponder chips
• CPC Class Codes: B01L 2300/0627 Sensor or part of a sensor is integrated
• CPC Class Codes: B01L 2300/0861 Configuration of multiple channels and/or chambers in a single devices
• CPC Class Codes: B01L 2300/1805 Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
• CPC Class Codes: B01L 2300/1822 using Peltier elements
• CPC Class Codes: B01L 2300/185 using a liquid as fluid
• CPC Class Codes: B01L 2400/04 Moving fluids with specific forces or mechanical means
• CPC Class Codes: B01L 2400/0487 fluid pressure, pneumatics
• CPC Class Codes: B01L 9/527 for microfluidic devices, e.g. used for lab-on-a-chip

Abstract

A chip-holder for holding a micro-fluidic chip has a fixer for detachably fixing the micro-fluidic chip in the chip-holder and at least one process control device configured to support control or monitoring of a chemical process in the micro-fluidic chip, wherein the chip-holder is configured such that the process control device and the micro-fluidic chip are directly and detachably coupled when the micro-fluidic chip is fixed in the chip-holder. Such a chip-holder brings along the advantage that the micro-fluidic chip can easily be removed and exchanged while the process control device can be reused. This reduces running costs of a chemical microreactor system drastically and allows for a very flexible usage of a chemical microreactor system.

Claims

1. A chip-holder for holding a micro-fluidic chip comprising an opening, the chip-holder comprising:

a process control device adapted to support control or monitoring of a chemical process in the micro-fluidic chip;

a printed circuit board adapted to provide electrical connection to the process control device; and

a fixer for detachably fixing the micro-fluidic chip in the chip-holder such that a surface of the micro-fluidic chip is adjacent to a surface of the printed circuit board;

wherein the process control device is a sensor or an actuator;

wherein the chip-holder is adapted such that the process control device and the micro-fluidic chip are directly and detachably coupled when the micro-fluidic chip is fixed in the chip-holder;

wherein the process control device is adapted such that the process control device is in a direct fluidic contact with the micro-fluidic chip via the opening of the micro-fluidic chip, when the micro-fluidic chip is fixed in the chip-holder;

wherein the process control device is a device chip attached to the printed circuit board;

wherein the chip holder comprises a sealing ring adapted to form a seal which is impermeable to a fluid in the micro-fluidic chip when a circumference of an opening in the surface of the micro-fluidic chip which is adjacent to the surface of the printed circuit board when the fixer fixes the micro-fluidic chip in the chip holder is in contact with the sealing ring, in order to form a fluid chamber bounded by the micro-fluidic chip, the sealing ring and at least one out of the printed circuit board and the process control device chip.

2. The chip-holder of claim 1, further comprising an electronic circuit for processing data from the sensor and for providing an information based on the data from the sensor.

3. The chip-holder of claim 1, further comprising an electronic circuit for providing an electrical signal to the actuator based on an information received from a control interface.

4. The chip-holder of claim 1, further comprising:

an actuator adapted to support control of the chemical process in the micro-fluidic chip;

an electronic circuit adapted to receive a sensor signal from the sensor and to provide an actuator control signal to the actuator,

wherein the chip-holder is adapted such that the actuator and the micro-fluidic chip are directly and detachably coupled when the micro-fluidic chip is fixed in the chip-holder; and

wherein the electronic circuit is adapted to implement a feedback control circuit for adjusting the actuator control signal in response to the sensor signal.

5. The chip-holder of claim 4, wherein the electronic circuit comprises a microprocessor and an interface circuitry for establishing a connection with an external computer device.

6. The chip-holder of claim 1, wherein the printed circuit board is adapted to be parallel to the micro-fluidic chip when the micro- fluidic chip is fixed in the chip-holder.

7. The chip-holder of claim 1, wherein the device chip comprises a top surface and a bottom surface, wherein an active sensor/actuator area for monitoring or controlling the chemical process is located on the top surface, wherein the bottom surface is attached to the printed circuit board and wherein an electrical connection between the top surface and the bottom surface is implemented using through-wafer interconnects.

8. The chip-holder of claim 7, wherein the device chip is attached to contact pads of the printed circuit board using bumps or conducting adhesive.

9. The chip-holder of claim 1, wherein the device chip comprises a top surface and a bottom surface, wherein an active sensor/actuator area for monitoring or controlling the chemical process is located on the bottom surface, and wherein the bottom surface is attached to the printed circuit board.

10. The chip-holder of claim 9, wherein the device chip is attached to contact pads of the printed circuit board using bumps or conductive adhesive.

11. The chip-holder of claim 9, wherein the device chip is adapted such that a fluid can pass through from the top surface to the bottom surface.

12. The chip-holder of claim 9, further comprising an underfiller layer adapted to fill a volume between the device chip and the printed circuit board.

13. The chip-holder of claim 12, wherein the underfiller layer comprises a recess adapted such that a fluid can contact the active area.

14. The chip-holder of claim 1, wherein the device chip is attached to the printed circuit board using a flip-chip technology.

15. The chip-holder of claim 1, wherein the device chip is an unpackaged chip.

16. The chip-holder of claim 1, wherein the process control device is adapted such that the process control device is in direct fluidic contact with a reactor channel of the micro-fluidic chip, when the micro-fluidic chip is fixed in the chip-holder.

17. The chip-holder of claim 1, wherein the device chip comprises a bottom surface adjacent to the printed circuit board, a top surface opposite to the bottom surface and at least one side surface adjacent to the bottom surface or adjacent to the top surface, wherein the device chip is encircled by a sealing ring contacting the printed circuit board and the at least one side surface of the device chip.

18. The chip-holder of claim 1, wherein the sealing ring comprises a circular or elliptic cross-section.

19. The chip-holder of claim 1, wherein the sealing ring is formed from an elastic polymer.

20. The chip-holder of claim 1, wherein the sealing ring is formed from silicone or viton.

21. The chip-holder of claim 1, further comprising a first fluidic connection to an inlet of the micro-fluidic chip, and a second fluidic connection to an outlet of the micro-fluidic chip.

22. The chip-holder of claim 1, further comprising a barcode reader integrated into the chip-holder and adapted to read a barcode tag of the micro-fluidic chip.

23. The chip-holder of claim 1, further comprising an ID-tag reader integrated into the chip-holder and adapted to read an ID-tag of the micro-fluidic chip.

24. The chip-holder of claim 23, wherein the ID-tag reader is adapted to read out an RF-ID-tag of the micro-fluidic chip.

25. The chip-holder of claim 1, further comprising an opening adapted to allow for an optical inspection of fluid channels of the micro-fluidic chip, when the micro-fluidic chip is fixed in the chip-holder.

26. The chip-holder of claim 1, wherein the chip-holder is adapted such that the micro-fluidic chip is fixed in the chip-holder by a mechanical pressure.

27. The chip-holder of claim 1, wherein the process control device is a temperature sensor, a pressure sensor, a flow sensor, a pH sensor, a conductivity measurement device, a reaction species measurement device, a reaction yield measurement device, a chemical analysis device, a heater, a cooler, a Peltier element, a flow activation device, a pressurizing device, a pump, a potential bias device or a charge delivery device.