Methods and compositions for inactivating glutamine synthetase gene expression
First Claim
Patent Images
1. A zinc finger DNA-binding domain comprising four, five or six zinc finger recognition regions designated F1 to F4, F1-F5 or F1 to F-6 as shown in a single row of Table 1.
1 Assignment
0 Petitions
Reexamination
Accused Products
Abstract
Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
-
Citations
18 Claims
- 1. A zinc finger DNA-binding domain comprising four, five or six zinc finger recognition regions designated F1 to F4, F1-F5 or F1 to F-6 as shown in a single row of Table 1.
Specification