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Toll like receptor 3 antagonists, methods and uses

  • US 8,153,583 B2
  • Filed: 11/30/2005
  • Issued: 04/10/2012
  • Est. Priority Date: 11/30/2004
  • Status: Active Grant
First Claim
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1. A method of treating an inflammatory condition comprising administering a therapeutically effective amount of a Toll Like Receptor 3 (TLR3) antagonist antibody to a patient in need thereof for a time sufficient to treat the inflammatory condition wherein the TLR3 antagonist antibody is an isolated antibody reactive with TLR3 comprising the amino acid sequences of the heavy chain complementarity determining regions (CDRs) of SEQ ID NOs:

  • 9, 11 and 13 and the amino acid sequences of the light chain CDRs of SEQ ID NOs;

    19, 21 and 23.

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