Polymer cement for percutaneous vertebroplasty and methods of using and making same

• US 8,153,704 B2
• Filed: 06/04/2007
• Issued: 04/10/2012
• Est. Priority Date: 05/14/2004
• Status: Expired due to Fees

• Current Assignee: Teknimed SA
• Original Assignee: Teknimed SA
• Inventors: Lavergne, Claudine, Leonard, Alain
• Primary Examiner(s): Yoon, Tae H
• Application Number:
  US11/757,427
• Publication Number:
  US 20080044374A1
• Time in Patent Office: 1,772 Days
• Field of Search: 523/117, 523/116
• US Class Current: 523/117
• CPC Class Codes: A61L 24/0094 containing macromolecular fillers
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/446 with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
• CPC Class Codes: C08L 33/12 Homopolymers or copolymers of methyl methacrylate

Abstract

The invention provides a fluid cement for medical use for bone reconstruction, in particular for filling the vertebral body, and a binary composition which is intended for the preparation of such a cement. The invention also provides a device for conditioning the binary composition, and a method of preparing a bone cement from a binary composition. The fluid cement according to the invention comprises: a) approximately 60% to 85% by weight of a polymer comprising a polymethylmethacrylate and a methylmethacrylate monomer and b) approximately from 15 to 40% by weight of a radio-opaque composition. Preferably, the radio-opaque composition comprises a radio-opacifier, such as barium sulfate and zirconium dioxide, in a mixture with a calcium phosphate, for example apatite hydroxide.

Claims

1. A polymer cement kit for bone filling comprising:

a) a receptacle comprising liquid components L, wherein the liquid components comprise a methylmethacrylate monomer (MMA), and

b) a receptacle comprising powder components P, wherein the powder components comprise a polymer component comprising polymethylmethacrylate homopolymer (PMMA) and at least 35% of a radio-opaque composition, wherein the radio-opaque composition comprises 25-50% of a radio-opaque compound and 4-12% calcium phosphate relative to the weight of the powder component P;

wherein the powder component P and the liquid component L are provided in a weight ratio P/L between 1.4 and 1.6.

2. The kit according to claim 1, characterized in that said radio-opaque compound is zirconium dioxide.

3. The kit according to claim 1, characterized in that said radio-opaque compound is barium sulfate.

4. The kit according to claim 1, characterized in that the calcium phosphate is hydroxyapatite.

5. The kit according to claim 1, characterized in that it comprises in addition an effective quantity of one or more of the reagents selected from the group consisting of a chemical polymerization activator, a polymerization initiator and a stabilizer.

6. The kit according to claim 5, wherein the chemical polymerization activator is dimethylparatoluidine.

7. The kit according to claim 5, wherein the polymerization initiator is benzoyl peroxide.

8. The kit according to claim 5, wherein the stabilizer is hydroquinone.

9. A method of preparing a fluid cement for tilling the vertebral body, comprising mixing the powder components P and liquid components L according to claim 1 into a homogeneous mass in a weight ratio P/L between 1.4 and 1.6.