Substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one-compounds and the use thereof for producing drugs

• US 8,153,795 B2
• Filed: 06/27/2006
• Issued: 04/10/2012
• Est. Priority Date: 06/27/2005
• Status: Expired due to Fees

• Current Assignee: Grunenthal GMBH (Grünenthal Pharma GmbH & Co. KG)
• Original Assignee: Grunenthal GMBH (Grünenthal Pharma GmbH & Co. KG)
• Inventors: Sundermann, Corinna, Przewosny, Michael, Sundermann, Bernd
• Primary Examiner(s): Andres, Janet
• Assistant Examiner(s): Reese, Heidi
• Application Number:
  US11/994,001
• Publication Number:
  US 20090105290A1
• Time in Patent Office: 2,114 Days
• Field of Search: None
• US Class Current: 546/19
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 1/12 Antidiarrhoeals
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 11/14 Antitussive agents
• CPC Class Codes: A61P 15/02 for disorders of the vagina
• CPC Class Codes: A61P 17/04 Antipruritics
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 25/08 Antiepileptics; Anticonvulsants
• CPC Class Codes: A61P 25/14 for treating abnormal movements, e.g. chorea, dyskinesia
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 25/18 Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• CPC Class Codes: A61P 25/22 Anxiolytics
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 25/32 Alcohol-abuse
• CPC Class Codes: A61P 25/34 Tobacco-abuse
• CPC Class Codes: A61P 25/36 Opioid-abuse
• CPC Class Codes: A61P 27/16 Otologicals
• CPC Class Codes: A61P 29/00 : Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/04 : Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/10 : Antioedematous agents; Diuretics
• CPC Class Codes: A61P 7/12 : Antidiuretics, e.g. drugs for diabetes insipidus ADH A61P5/10
• CPC Class Codes: A61P 9/10 : for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07D 498/10 : Spiro-condensed systems

Abstract

The present invention relates to substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one compounds, to methods for the production thereof, to medicaments containing these compounds and to the use of these compounds for producing medicaments.

Claims

1. A substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one compound corresponding to formula I

2. A compound as claimed in claim 1, wherein said compound contains at least one chiral carbon atom and is present in the form of an isolated or purified stereoisomer.

3. A compound as claimed in claim 1, wherein said compound contains at least one chiral carbon atom and is present in the form of a mixture of stereoisomers in any mixing ratio.

4. A compound as claimed in claim 1, wherein said compound is present in the form of a racemic mixture.

5. A compound as claimed in claim 1 wherein R¹ denotes a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,4]-oxadiazolyl, benzo[2,1,3]thiadiazolyl, [1,2,3]-benzothiadiazolyl, [2,1,3]-benzoxadiazolyl, [1,2,3]-benzoxadiazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl, [3,4]-dihydro-2H-1,4-benzoxazinyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group may in optionally be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, SH, —

S—

CH₃, —

S—

C₂H₅, —

S—

CH(CH₃)₂, —

S—

CH₂—

CH₂—

CH₃, —

S—

C(CH₃)₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

NH—

C(═

O)—

O—

CH₃, —

NH—

C(═

O)—

O—

C₂H₅, —

NH—

C(═

O)—

O—

C(CH₃)₃, —

NH—

C(═

O)—

CH₃, —

NH—

C(═

O)—

C₂H₅, —

NH—

C(═

O)—

C(CH₃)₃, —

C(═

O)—

H, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃, —

S(═

O)₂—

NH₂, phenyl and benzyl, wherein the cyclic moiety of each phenyl or benzyl group independently may optionally be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

OH, —

CF₃, —

SF₅, —

NO₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, phenyl and —

O-benzyl.

6. A compound as claimed in claim 1, wherein

R² denotes —

C(═

S)—

NH—

R³;

—

C(═

O)—

NH—

R⁴;

—

S(═

O)₂—

R⁵;

—

(CH₂)—

C(═

O)—

NH—

R⁶;

—

(CH₂)—

O—

R⁷, —

(CH₂)—

S—

R⁷, —

(CH₂)—

NH—

R⁷, —

(CH₂)—

N(CH₃)—

R⁷, —

(CH₂)—

(CH₂)—

O—

R⁷, —

(CH₂)—

(CH₂)—

S—

R⁷, —

(CH₂)—

NH—

R⁷, —

(CH₂)—

N(CH₃)—

R⁷, —

(CH₂)—

(CH₂)—

(CH₂)—

O—

R⁷, —

(CH₂)—

(CH₂)—

(CH₂)—

S—

R⁷, —

(CH₂)—

(CH₂)—

(CH₂)—

NH—

R⁷, —

(CH₂)—

(CH₂)—

(CH₂)—

N(CH₃)—

R⁷, —

(CH₂)—

O—

(CH₂)—

R⁷, —

(CH₂)—

S—

(CH₂)—

R⁷;

—

(CH₂)—

NH—

(CH₂)—

R⁷;

—

C(═

O)—

R⁸ or —

S(═

O)₂—

NR⁹R¹⁰.

7. A compound as claimed in claim 1, wherein

R³ denotes

—

(CHR¹¹)—

C(═

O)—

O—

R¹² or —

(CHR¹¹)—

(CH₂)—

C(═

O)—

O—

R¹²;

—

(CHR¹³)—

R¹⁴, —

(CHR¹³)—

(CH₂)—

R¹⁴, —

(CHR¹³)—

(CH₂)—

(CH₂)—

R¹⁴, —

(CHR¹³)—

O—

R¹⁴, —

(CHR¹³)—

S—

R¹⁴, —

(CHR¹³)—

NH—

R¹⁴, —

(CHR¹³)—

N(CH₃)—

R¹⁴, —

(CHR¹³)—

(CH₂)—

O—

R¹⁴, —

(CHR¹³)—

(CH₂)—

S—

R¹⁴, —

(CHR¹³)—

NH—

R¹⁴, —

(CHR¹³)—

N(CH₃)—

R¹⁴, —

(CHR¹³)—

(CH₂)—

(CH₂)—

O—

R¹⁴, —

(CHR¹³)—

(CH₂)—

(CH₂)—

S—

R¹⁴, —

(CHR¹³)—

(CH₂)—

(CH₂)—

NH—

R¹⁴, —

(CHR¹³)—

(CH₂)—

(CH₂)—

N(CH₃)—

R¹⁴, —

(CHR¹³)—

O—

(CH₂)—

R¹⁴, —

(CHR¹³)—

S—

(CH₂)—

R¹⁴ or —

(CHR¹³)—

NH—

(CH₂)—

R¹⁴;

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, n-heptyl, n-octyl, —

(CH₂)—

(CH)(C₂H₅)—

(CH₂)—

(CH₂)—

(CH₂)—

(CH₃), vinyl, 1-propenyl, 2-propenyl, 1-butenyl, 2-butenyl and 3-butenyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

NO₂, —

OH, —

SH and —

NH₂;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, imidazolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, thiomorpholinyl, tetrahydropyranyl, azepanyl, diazepanyl and dithiolanyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of oxo (═

O), thioxo (═

S), —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃ and —

S(═

O)₂—

NH₂;

or

a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,4]-oxadiazolyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, SH, —

S—

CH₃, —

S—

C₂H₅, —

S—

CH(CH₃)₂, —

S—

CH₂—

CH₂—

CH₃, —

S—

C(CH₃)₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

NH—

C(═

O)—

O—

CH₃, —

NH—

C(═

O)—

O—

C₂H₅, —

NH—

C(═

O)—

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NH—

C(═

O)—

CH₃, —

NH—

C(═

O)—

C₂H₅, —

NH—

C(═

O)—

C(CH₃)₃, —

C(═

O)—

H, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

C(═

O)—

OH, —

(CH₂)—

C(═

O)—

OH, —

C(═

O)—

O—

CH₃, —

C(═

O)—

O—

CH₂—

CH₃, —

C(═

O)—

O—

CH(CH₃)₂, —

C(═

O)—

O—

C(CH₃)₃, —

NH—

CH₃, —

NH—

C₂H₅, —

NH—

CH(CH₃)₂, —

NH—

C(CH₃)₃, —

N(CH₃)₂, —

N(C₂H₅)₂, —

N(CH₃)(C₂H₅), —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃, —

S(═

O)₂—

NH₂, phenyl and benzyl, wherein the cyclic moiety of each phenyl or benzyl group independently may optionally be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

OH, —

CF₃, —

SF₅, —

NO₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, phenyl and —

O-benzyl.

8. A compound as claimed in claim 1, wherein

R⁴ denotes

—

(CHR¹⁵)—

R¹⁶, —

(CHR¹⁵)—

(CH₂)—

R¹⁶, —

(CHR¹⁵)—

(CH₂)—

(CH₂)—

R¹⁶, —

(CHR¹⁵)—

O—

R¹⁶, —

(CHR¹⁵)—

S—

R¹⁶, —

(CHR¹⁵)—

NH—

R¹⁶, —

(CHR¹⁵)—

N(CH₃)—

R¹⁶, —

(CHR¹⁵)—

(CH₂)—

O—

R¹⁶, —

(CHR¹⁵)—

(CH₂)—

S—

R¹⁶, —

(CHR¹⁵)—

NH—

R¹⁶, —

(CHR¹⁵)—

N(CH₃)—

R¹⁶, —

(CHR¹⁵)—

(CH₂)—

(CH₂)—

O—

R¹⁶, —

(CHR¹⁵)—

(CH₂)—

(CH₂)—

S—

R¹⁶, —

(CHR¹⁵)—

(CH₂)—

(CH₂)—

NH—

R¹⁶, —

(CHR¹⁵)—

(CH₂)—

(CH₂)—

N(CH₃)—

R¹⁶, —

(CHR¹⁵)—

O—

(CH₂)—

R¹⁶, —

(CHR¹⁵)—

S—

(CH₂)—

R¹⁶ or —

(CHR¹⁵)—

NH—

(CH₂)—

R¹⁶;

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, n-heptyl, n-octyl, —

(CH₂)—

(CH)(C₂H₅)—

(CH₂)—

(CH₂)—

(CH₂)—

(CH₃), vinyl, 1-propenyl, 2-propenyl, 1-butenyl, 2-butenyl and 3-butenyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

NO₂, —

OH, —

SH and —

NH₂;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, imidazolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, thiomorpholinyl, tetrahydropyranyl, azepanyl, diazepanyl and dithiolanyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of oxo (═

O), thioxo (═

S), —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃ and —

S(═

O)₂—

NH₂;

or

a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,4]-oxadiazolyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein the said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, SH, —

S—

CH₃, —

S—

C₂H₅, —

S—

CH(CH₃)₂, —

S—

CH₂—

CH₂—

CH₃, —

S—

C(CH₃)₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

NH—

C(═

O)—

O—

CH₃, —

NH—

C(═

O)—

O—

C₂H₅, —

NH—

C(═

O)—

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NH—

C(═

O)—

CH₃, —

NH—

C(═

O)—

C₂H₅, —

NH—

C(═

O)—

C(CH₃)₃, —

C(═

O)—

OH, —

(CH₂)—

C(═

O)—

OH, —

C(═

O)—

O—

CH₃, —

C(═

O)—

O—

CH₂—

CH₃, —

C(═

O)—

O—

CH(CH₃)₂, —

C(═

O)—

O—

C(CH₃)₃, —

NH—

CH₃, —

NH—

C₂H₅, —

NH—

CH(CH₃)₂, —

NH—

C(CH₃)₃, —

N(CH₃)₂, —

N(C₂H₅)₂, —

N(CH₃)(C₂H₅), —

C(═

O)—

H, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃, —

S(═

O)₂—

NH₂, phenyl and benzyl, wherein the cyclic moiety of each phenyl or benzyl group independently may optionally be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

OH, —

CF₃, —

SF₅, —

NO₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, phenyl and —

O-benzyl.

9. A compound as claimed in claim 1, wherein

R⁵ denotes

—

(CHR¹⁷)—

R¹⁸, —

(CHR¹⁷)—

(CH₂)—

R¹⁸, —

(CHR¹⁷)—

(CH₂)—

(CH₂)—

R¹⁸, —

(CHR¹⁷)—

O—

R¹⁸, —

(CHR¹⁷)—

S—

R¹⁸, —

(CHR¹⁷)—

NH—

R¹⁸, —

(CHR¹⁷)—

N(CH₃)—

R¹⁸, —

(CHR¹⁷)—

(CH₂)—

O—

R¹⁸, —

(CHR¹⁷)—

(CH₂)—

S—

R¹⁸, —

(CHR¹⁷)—

NH—

R¹⁸, —

(CHR¹⁷)—

N(CH₃)—

R¹⁸, —

(CHR¹⁷)—

(CH₂)—

(CH₂)—

O—

R¹⁸, —

(CHR¹⁷)—

(CH₂)—

(CH₂)—

S—

R¹⁸, —

(CHR¹⁷)—

(CH₂)—

(CH₂)—

NH—

R¹⁸, —

(CHR¹⁷)—

(CH₂)—

(CH₂)—

N(CH₃)—

R¹⁸, —

(CHR¹⁷)—

O—

(CH₂)—

R¹⁸, —

(CHR¹⁷)—

S—

(CH₂)—

R¹⁸ or —

(CHR¹⁷)—

NH—

(CH₂)—

R¹⁸;

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, n-heptyl, n-octyl, —

(CH₂)—

(CH)(C₂H₅)—

(CH₂)—

(CH₂)—

(CH₂)—

(CH₃), vinyl, 1-propenyl, 2-propenyl, 1-butenyl, 2-butenyl and 3-butenyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

NO₂, —

OH, —

SH and —

NH₂;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, imidazolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, thiomorpholinyl, tetrahydropyranyl, azepanyl, diazepanyl and dithiolanyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of oxo (═

O), thioxo (═

S), —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃ and —

S(═

O)₂—

NH₂;

or

a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,4]-oxadiazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, SH, —

S—

CH₃, —

S—

C₂H₅, —

S—

CH(CH₃)₂, —

S—

CH₂—

CH₂—

CH₃, —

S—

C(CH₃)₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

NH—

C(═

O)—

O—

CH₃, —

NH—

C(═

O)—

O—

C₂H₅, —

NH—

C(═

O)—

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NH—

C(═

O)—

CH₃, —

NH—

C(═

O)—

C₂H₅, —

NH—

C(═

O)—

C(CH₃)₃, —

C(═

O)—

OH, —

(CH₂)—

C(═

O)—

OH, —

C(═

O)—

O—

CH₃, —

C(═

O)—

O—

CH₂—

CH₃, —

C(═

O)—

O—

CH(CH₃)₂, —

C(═

O)—

O—

C(CH₃)₃, —

NH—

CH₃, —

NH—

C₂H₅, —

NH—

CH(CH₃)₂, —

NH—

C(CH₃)₃, —

N(CH₃)₂, —

N(C₂H₅)₂, —

N(CH₃)(C₂H₅), —

C(═

O)—

H, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃, —

S(═

O)₂—

NH₂, phenyl and benzyl, wherein the cyclic moiety of each phenyl or benzyl group independently may optionally be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

OH, —

CF₃, —

SF₅, —

NO₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, phenyl and —

O-benzyl.

10. A compound as claimed in claim 1, wherein

R⁶ denotes

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, n-heptyl, n-octyl, —

(CH₂)—

(CH)(C₂H₅)—

(CH₂)—

(CH₂)—

(CH₂)—

(CH₃), vinyl, 1-propenyl, 2-propenyl, 1-butenyl, 2-butenyl and 3-butenyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

NO₂, —

OH, —

SH and —

NH₂;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, imidazolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, thiomorpholinyl, tetrahydropyranyl, azepanyl, diazepanyl and dithiolanyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of oxo (═

O), thioxo (═

S), —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃ and —

S(═

O)₂—

NH₂;

or

a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,4]-oxadiazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, SH, —

S—

CH₃, —

S—

C₂H₅, —

S—

CH(CH₃)₂, —

S—

CH₂—

CH₂—

CH₃, —

S—

C(CH₃)₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

NH—

C(═

O)—

O—

CH₃, —

NH—

C(═

O)—

O—

C₂H₅, —

NH—

C(═

O)—

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NH—

C(═

O)—

CH₃, —

NH—

C(═

O)—

C₂H₅, —

NH—

C(═

O)—

C(CH₃)₃, —

C(═

O)—

OH, —

(CH₂)—

C(═

O)—

OH, —

C(═

O)—

O—

CH₃, —

C(═

O)—

O—

CH₂—

CH₃, —

C(═

O)—

O—

CH(CH₃)₂, —

C(═

O)—

O—

C(CH₃)₃, —

NH—

CH₃, —

NH—

C₂H₅, —

NH—

CH(CH₃)₂, —

NH—

C(CH₃)₃, —

N(CH₃)₂, —

N(C₂H₅)₂, —

N(CH₃)(C₂H₅), —

C(═

O)—

H, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃, —

S(═

O)₂—

NH₂, —

S(═

O)₂—

NH-phenyl, phenyl and benzyl, wherein in each case the cyclic moiety of the groups —

S(═

O)₂—

NH-phenyl, phenyl and benzyl may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

OH, —

CF₃, —

SF₅, —

NO₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, phenyl and —

O-benzyl.

11. A compound as claimed in claim 1 wherein

R⁸ denotes

—

(CHR¹⁹)—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

(CH₂)—

R²⁰, —

(CHR¹⁹)—

O—

R²⁰, —

(CHR¹⁹)—

S—

R²⁰, —

(CHR¹⁹)—

NH—

R²⁰, —

(CHR¹⁹)—

N(CH₃)—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

O—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

S—

R²⁰, —

(CHR¹⁹)—

NH—

R²⁰, —

(CHR¹⁹)—

N(CH₃)—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

(CH₂)—

O—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

(CH₂)—

S—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

(CH₂)—

NH—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

(CH₂)—

N(CH₃)—

R²⁰, —

(CHR¹⁹)—

O—

(CH₂)—

R²⁰, —

(CHR¹⁹)—

S—

(CH₂)—

R²⁰, —

(CHR¹⁹)—

NH—

(CH₂)—

R²⁰, —

(CHR¹⁹)—

O—

(CH₂)—

(CH₂)—

O—

R²⁰, —

(CHR¹⁹)—

O—

(CH₂)—

(CH₂)—

S—

R²⁰ or —

(CHR¹⁹)—

S—

(CH₂)—

(CH₂)—

S—

R²⁰;

—

(CH═

CH)—

R²¹;

—

(CR²²R²³)—

C(═

O)—

O—

R²⁶, —

(CR²²R²³)—

(CR²⁴R²⁵)—

C(═

O)—

O—

R²⁶, —

(CR²²R²³)—

(CR²⁴R²⁵)—

(CH₂)—

C(═

O)—

O—

R²⁶, —

(CR²²R²³)—

O(CR²⁴R²⁵)—

C(═

O)—

O—

R²⁶, —

(CR²²R²³)—

S—

(CR²⁴R²⁵)—

C(═

O)—

O—

R²⁶ or denotes —

(CR²²R²³)—

NH—

(CR²⁴R²⁵)—

C(═

O)—

O—

R²⁶;

—

(CHR²⁷)—

O—

C(═

O)—

R²⁸;

—

CH[(CH₂)R²⁹][NH—

S(═

O)₂—

R³⁰];

—

CH[(CH₂)R³¹][NH—

C(═

O)—

O—

R³²];

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, 3-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, 2-hexyl, 3-hexyl, n-heptyl, 2-heptyl, 3-heptyl, 4-heptyl, n-octyl, —

(CH₂)—

(CH)(C₂H₅)—

(CH₂)—

(CH₂)—

(CH₂)—

(CH₃), vinyl, 1-propenyl, 2-propenyl, 1-butenyl, 2-butenyl and 3-butenyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

NO₂, —

OH, —

SH and —

NH₂;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, imidazolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, thiomorpholinyl, tetrahydropyranyl, azepanyl, diazepanyl, dithiolanyl, adamantyl and bicyclo[2.2.1]heptyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of oxo (═

O), thioxo (═

S), —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, —

(CH₂)—

C(═

O)—

OH, —

C(═

O)—

OH, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃, phenyl and —

S(═

O)₂—

NH₂;

wherein the phenyl group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃ and —

O—

CH₂—

CH₂—

CH₂—

CH₃;

or

a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,4]-oxadiazolyl, benzo[2,1,3]thiadiazolyl, [1,2,3]-benzothiadiazolyl, [2,1,3]-benzoxadiazolyl, [1,2,3]-benzoxadiazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, —

SH, —

S—

CH₃, —

S—

C₂H₅, —

S—

CH(CH₃)₂, —

S—

CH₂—

CH₂—

CH₃, —

S—

C(CH₃)₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

NH—

C(═

O)—

O—

CH₃, —

NH—

C(═

O)—

O—

C₂H₅, —

NH—

C(═

O)—

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NH—

C(═

O)—

CH₃, —

NH—

C(═

O)—

C₂H₅, —

NH—

C(═

O)—

C(CH₃)₃, —

C(═

O)—

OH, —

(CH₂)—

C(═

O)—

OH, —

C(═

O)—

O—

CH₃, —

C(═

O)—

O—

CH₂—

CH₃, —

C(═

O)—

O—

CH(CH₃)₂, —

C(═

O)—

O—

C(CH₃)₃, —

NH—

CH₃, —

NH—

C₂H₅, —

NH—

CH(CH₃)₂, —

NH—

C(CH₃)₃, —

N(CH₃)₂, —

N(C₂H₅)₂, —

N(CH₃)(C₂H₅), —

C(═

O)—

H, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃, —

S(═

O)₂—

NH₂, —

S(═

O)₂—

NH-phenyl, phenyl, —

O-phenyl, —

O-benzyl and benzyl, wherein the cyclic moiety of the groups —

S(═

O)₂—

NH-phenyl, phenyl, —

O-phenyl, —

O-benzyl and benzyl optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

OH, —

CF₃, —

SF₅, —

NO₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, phenyl and —

O-benzyl.

12. A compound as claimed in claim 1 wherein

R⁹ and R¹⁰ each independently denote a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, 3-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, 2-hexyl, 3-hexyl, n-heptyl, 2-heptyl, 3-heptyl, 4-heptyl and n-octyl.

13. A compound as claimed in claim 1 wherein

R¹¹, R¹³, R¹⁵, R¹⁷, R¹⁹, R²², R²³, R²⁴, R²⁵ and R²⁶ each independently denote hydrogen or a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, 3-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, 2-hexyl, 3-hexyl, n-heptyl, 2-heptyl, 3-heptyl, 4-heptyl and n-octyl.

14. A compound as claimed in claim 1 wherein

R¹², R²⁸ and R³² each independently denote a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, 3-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, 2-hexyl, 3-hexyl, n-heptyl, 2-heptyl, 3-heptyl, 4-heptyl and n-octyl.

15. A compound as claimed in claim 1 wherein

R¹⁴, R¹⁶, R¹⁸ and R²⁰ each independently denote

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, 3-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, 2-hexyl, 3-hexyl, n-heptyl, 2-heptyl, 3-heptyl, 4-heptyl and n-octyl;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, imidazolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, thiomorpholinyl, tetrahydropyranyl, azepanyl, diazepanyl, dithiolanyl, adamantyl and bicyclo[2.2.1]heptyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of oxo (═

O), thioxo (═

S), —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, —

(CH₂)—

C(═

O)—

OH, —

C(═

O)—

OH, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

C(═

O)—

NH₂, —

C(═

O)—

NH—

CH₃, —

C(═

O)—

NH—

C₂H₅, —

C(═

O)—

NH—

C(CH₃)₃, —

C(═

O)—

N(CH₃)₂, —

C(═

O)—

N(C₂H₅)₂, —

S(═

O)₂—

CH₃, —

S(═

O)₂—

C₂H₅, —

NH—

S(═

O)₂—

CH₃, —

S(═

O)₂—

NH—

CH₃ and —

S(═

O)₂—

NH₂;

or

a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,4]-oxadiazolyl, benzo[2,1,3]thiadiazolyl, [1,2,3]-benzothiadiazolyl, [2,1,3]-benzoxadiazolyl, [1,2,3]-benzoxadiazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, —

SH, —

S—

CH₃, —

S—

C₂Hs, —

S—

CH(CH₃)₂, —

S—

CH₂—

CH₂—

CH₃, —

S—

C(CH₃)₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

NH—

C(═

O)—

CH₃, —

NH—

C(═

O)—

C₂H₅, —

NH—

CH₃, —

NH—

C₂H₅, —

NH—

CH(CH₃)₂, —

NH—

C(CH₃)₃, —

N(CH₃)₂, —

N(C₂H₅)₂, —

N(CH₃)(C₂H₅) and S(═

O)₂—

NH₂.

16. A compound as claimed in claim 1 wherein

R²¹, R²⁷, R²⁹, R³⁰ and R³¹ each independently denote a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,4]-oxadiazolyl, benzo[2,1,3]thiadiazolyl, [1,2,3]-benzothiadiazolyl, [2,1,3]-benzoxadiazolyl, [1,2,3]-benzoxadiazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, —

SH, —

S—

CH₃, —

S—

C₂H₅, —

S—

CH(CH₃)₂, —

S—

CH₂—

CH₂—

CH₃, —

S—

C(CH₃)₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

NH—

C(═

O)—

CH₃, —

NH—

C(═

O)—

C₂H₅, —

NH—

CH₃, —

NH—

C₂H₅, —

NH—

CH(CH₃)₂, —

NH—

C(CH₃)₃, —

N(CH₃)₂, —

N(C₂H₅)₂, —

N(CH₃)(C₂H₅) and S(═

O)₂—

NH₂.

17. A compound as claimed in claim 1 wherein n is 1, 2 or 3;

R¹ denotes a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,4]-oxadiazolyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, phenyl and benzyl, wherein the cyclic moiety of the phenyl and benzyl groups optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃ and —

O—

C(CH₃)₃;

R² denotes

—

C(═

S)—

NH—

R³;

—

C(═

O)—

NH—

R⁴;

—

S(═

O)₂—

R⁵;

—

(CH₂)—

C(═

O)—

NH—

R⁶;

—

(CH₂)—

O—

R⁷, —

(CH₂)—

S—

R⁷, —

(CH₂)—

NH—

R⁷, —

(CH₂)—

N(CH₃)—

R⁷, —

(CH₂)—

(CH₂)—

O—

R⁷, —

(CH₂)—

(CH₂)—

S—

R⁷, —

(CH₂)—

NH—

R⁷, —

(CH₂)—

N(CH₃)—

R⁷, —

(CH₂)—

(CH₂)—

(CH₂)—

O—

R⁷, —

(CH₂)—

(CH₂)—

(CH₂)—

S—

R⁷, —

(CH₂)—

(CH₂)—

(CH₂)—

NH—

R⁷, —

(CH₂)—

(CH₂)—

(CH₂)—

N(CH₃)—

R⁷, —

(CH₂)—

O—

(CH₂)—

R⁷, —

(CH₂)—

S—

(CH₂)—

R⁷, or —

(CH₂)—

NH—

(CH₂)—

R⁷;

—

C(═

O)—

R⁸, or

—

S(═

O)₂—

NR⁹R¹⁰;

R³ denotes

—

(CHR¹¹)—

C(═

O)—

O—

R¹² or —

(CHR¹¹)—

(CH₂)—

C(═

O)—

O—

R¹²;

—

(CHR¹³)—

R¹⁴, —

(CHR¹³)—

(CH₂)—

R¹⁴, —

(CHR¹³)—

(CH₂)—

(CH₂)—

R¹⁴, —

(CHR¹³)—

O—

R¹⁴, —

(CHR¹³)—

(CH₂)—

O—

R¹⁴, —

(CHR¹³)—

(CH₂)—

(CH₂)—

O—

R¹⁴ or —

(CHR¹³)—

O—

(CH₂)—

R¹⁴;

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, n-heptyl, n-octyl, —

(CH₂)—

(CH)(C₂H₅)—

(CH₂)—

(CH₂)—

(CH₂)—

(CH₃), vinyl, 1-propenyl, 2-propenyl, 1-butenyl, 2-butenyl and 3-butenyl;

or

a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃ and —

C(═

O)—

C₂F₅;

R⁴ denotes

—

(CHR¹⁵)—

R¹⁶, —

(CHR¹⁵)—

(CH₂)—

R¹⁶ or —

(CHR¹⁵)—

(CH₂)—

(CH₂)—

R¹⁶;

or

a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

NO₂, —

CF₃, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

C(═

O)—

O—

CH₃, —

C(═

O)—

O—

CH₂—

CH₃, —

C(═

O)—

O—

CH(CH₃)₂, —

C(═

O)—

O—

C(CH₃)₃, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃ and —

C(═

O)—

C₂F₅;

R⁵ denotes

—

(CHR¹⁷)—

R¹⁸, —

(CHR¹⁷)—

(CH₂)—

R¹⁸ or —

(CHR¹⁷)—

(CH₂)—

(CH₂)—

R¹⁸;

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, n-heptyl, n-octyl and —

(CH₂)—

(CH)(C₂H₅)—

(CH₂)—

(CH₂)—

(CH₂)—

(CH₃);

or

a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

C(═

O)—

O—

CH₃, —

C(═

O)—

O—

CH₂—

CH₃, —

C(═

O)—

O—

CH(CH₃)₂, —

C(═

O)—

O—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

S(═

O)₂—

CH₃ and —

S(═

O)₂—

C₂H₅;

R⁶ denotes a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

CF₃, —

CN, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

S(═

O)₂—

NH-phenyl, phenyl and benzyl, wherein the cyclic moiety of the —

S(═

O)₂—

NH-phenyl, phenyl and benzyl groups optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl and Br;

R⁷ denotes a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,4]-oxadiazolyl, [1,2,3]-thiadiazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

CH₃, —

O—

C₂H₅, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, phenyl and benzyl, wherein the cyclic moiety of the phenyl and benzyl groups optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃ and —

O—

CH₂—

CH₂—

CH₂—

CH₃;

R⁸ denotes

—

(CHR¹⁹)—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

(CH₂)—

R²⁰, —

(CHR¹⁹)—

O—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

O—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

(CH₂)—

O—

R²⁰, —

(CHR¹⁹)—

O—

(CH₂)—

R²⁰ or —

(CHR¹⁹)—

O—

(CH₂)—

(CH₂)—

O—

R²⁰;

—

(CH═

CH)—

R²¹;

—

(CR²²R²³)—

C(═

O)—

O—

R²⁶, —

(CR²²R²³)—

(CR²⁴R²⁵)—

C(═

O)—

O—

R²⁶, —

(CR²²R²³)—

(CR²⁴R²⁵)—

(CH₂)—

C(═

O)—

O—

R²⁶ or —

(CR²²R²³)—

O—

(CR²⁴R²⁵)—

C(═

O)—

O—

R²⁶;

—

(CHR²⁷)—

O—

C(═

O)—

R²⁸;

—

CH[(CH₂)R²⁹][NH—

S(═

O)₂—

R³⁰];

—

CH[(CH₂)R³¹][NH—

C(═

O)—

O—

R³²];

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, 3-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, 2-hexyl, 3-hexyl, n-heptyl, 2-heptyl, 3-heptyl, 4-heptyl and n-octyl;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, imidazolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, thiomorpholinyl, tetrahydropyranyl, azepanyl, diazepanyl, dithiolanyl, adamantyl and bicyclo[2.2.1]heptyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃ and phenyl;

or

a group selected from the group consisting of phenyl, naphthyl, (1,3)-benzodioxolyl, (1,4)-benzodioxanyl, 2H-chromenyl, thiophenyl, furanyl, pyrrolyl, pyrazolyl, pyrazinyl, pyranyl, triazolyl, pyridinyl, imidazolyl, indolyl, isoindolyl, benzo[b]furanyl, benzo[b]thiophenyl, thiazolyl, [1,2,3]-thiadiazolyl, [1,2,4]-oxadiazolyl, benzo[2,1,3]thiadiazolyl, [1,2,3]-benzothiadiazolyl, [2,1,3]-benzoxadiazolyl, [1,2,3]-benzoxadiazolyl, [1,2,3,4]-tetrahydronaphthyl, [1,2,3,4]-tetrahydroquinolinyl, [1,2,3,4]-tetrahydroisoquinolinyl, [1,2,3,4]-tetrahydroquinazolinyl, oxazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl, indazolyl, quinazolinyl, quinolinyl and isoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

CN, —

CF₃, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, —

S—

CH₃, —

S—

C₂H₅, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

NH—

C(═

O)—

CH₃, —

NH—

C(═

O)—

C₂H₅, —

NH—

CH₃, —

NH—

C₂H₅, —

NH—

CH(CH₃)₂, —

NH—

C(CH₃)₃, —

N(CH₃)₂, —

N(C₂H₅)₂, —

N(CH₃)(C₂H₅), —

S(═

O)₂—

NH₂, phenyl, —

O-phenyl, —

O-benzyl and benzyl, wherein the cyclic moiety of the phenyl, —

O-phenyl, —

O-benzyl, and benzyl groups optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

OH, —

CF₃, —

SF₅, —

NO₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, phenyl and —

O-benzyl;

R⁹ and R¹⁰ each independently denote a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, 3-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, 2-hexyl, 3-hexyl, n-heptyl, 2-heptyl, 3-heptyl, 4-heptyl and n-octyl;

R¹¹, R¹³, R¹⁵, R¹⁷, R¹⁹, R²², R²³, R²⁴, R²⁵ and R²⁶ each independently denote hydrogen or a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

R¹², R²⁸ and R³² each independently denote a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

R¹⁴, R¹⁶, R¹⁸ and R²⁰ each independently denote

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, tetrahydrofuranyl, tetrahydrothiophenyl, tetrahydropyranyl and bicyclo[2.2.1]heptyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of oxo (═

O), thioxo (═

S), methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

(CH₂)—

C(═

O)—

OH and —

C(═

O)—

OH;

or

a group selected from the group consisting of phenyl, and naphthyl, wherein said phenyl or naphthyl group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl and n-heptyl; and

R²¹, R²⁷, R²⁹, R³⁰ and R³¹ each independently denote a group selected from the group consisting of phenyl, naphthyl, indolyl and isoindolyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl and n-heptyl.

18. A compound as claimed in claim 1 wherein n is 1 or 2;

R¹ denotes a group selected from the group consisting of phenyl and naphthyl,

wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

SF₅, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, phenyl and benzyl;

R² denotes

—

C(═

S)—

NH—

R³;

—

C(═

O)—

NH—

R⁴;

—

S(═

O)₂—

R⁵;

—

(CH₂)—

C(═

O)—

NH—

R⁶;

—

(CH₂)—

O—

R⁷, —

(CH₂)—

(CH₂)—

O—

R⁷ or —

(CH₂)—

(CH₂)—

(CH₂)—

O—

R⁷;

—

C(═

O)—

R⁸, or

—

S(═

O)₂—

NR⁹R¹⁰;

R³ denotes

—

(CHR¹¹)—

(CH₂)—

C(═

O)—

O—

R¹²;

—

(CHR¹³)—

R¹⁴, —

(CHR¹³)—

(CH₂)—

R¹⁴, —

(CHR¹³)—

(CH₂)—

(CH₂)—

R¹⁴ or denotes —

(CHR¹³)—

(CH₂)—

O—

R¹⁴;

a group selected from the group consisting of vinyl, 1-propenyl, 2-propenyl, 1-butenyl, 2-butenyl and 3-butenyl;

or

a phenyl group, wherein said phenyl group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃ and —

C(═

O)—

C₂F₅;

R⁴ denotes

—

(CHR¹⁵)—

R¹⁶, —

(CHR¹⁵)—

(CH₂)—

R¹⁶ or —

(CHR¹⁵)—

(CH₂)—

(CH₂)—

R¹⁶;

or

a group selected from the group consisting of phenyl and naphthyl, wherein said phenyl or naphthyl group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

NO₂, I, —

CN, —

CF₃, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl, —

C(═

O)—

O—

CH₃, —

C(═

O)—

O—

CH₂—

CH₃, —

C(═

O)—

O—

CH(CH₃)₂, —

C(═

O)—

O—

C(CH₃)₃, —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃, —

C(═

O)—

CF₃ and —

C(═

O)—

C₂F₅;

R⁵ denotes

—

(CHR¹⁷)—

R¹⁸, —

(CHR¹⁷)—

(CH₂)—

R¹⁸ or —

(CHR¹⁷)—

(CH₂)—

(CH₂)—

R¹⁸;

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, n-heptyl, n-octyl and —

(CH₂)—

(CH)(C₂H₅)—

(CH₂)—

(CH₂)—

(CH₂)—

(CH₃);

or

a group selected from the group consisting of phenyl, naphthyl, pyrazolyl, thiophenyl, [1,2,3,4]-tetrahydroquinolinyl and [1,2,3,4]-tetrahydroisoquinolinyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, I, —

CN, —

CF₃, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

C(═

O)—

O—

CH₃, —

C(═

O)—

O—

CH₂—

CH₃, —

C(═

O)—

O—

CH(CH₃)₂, —

C(═

O)—

O—

C(CH₃)₃, —

C(═

O)—

CF₃, —

C(═

O)—

C₂F₅, —

S(═

O)₂—

CH₃ and —

S(═

O)₂—

C₂H₅;

R⁶ denotes a group selected from the group consisting of phenyl, naphthyl, pyrazolyl, thiophenyl and thiazolyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

CF₃, —

CN, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

O—

CF₃, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

S(═

O)₂—

NH-phenyl, phenyl and benzyl, wherein the cyclic moiety of the —

S(═

O)₂—

NH-phenyl, phenyl and benzyl groups optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl and Br;

R⁷ denotes a group selected from the group consisting of phenyl, naphthyl, benzo[b]furanyl, benzo[b]thiophenyl and [1,2,4]-oxadiazolyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

CN, —

CF₃, —

SF₅, —

OH, —

O—

CH₃, —

O—

C₂H₅, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, phenyl and benzyl, wherein the cyclic moiety of the phenyl and benzyl groups optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃ and —

O—

CH₂—

CH₂—

CH₂—

CH₃;

R⁸ denotes

—

(CHR¹⁹)—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

(CH₂)—

R²⁰, —

(CHR¹⁹)—

O—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

O—

R²⁰, —

(CHR¹⁹)—

(CH₂)—

(CH₂)—

O—

R²⁰, —

(CHR¹⁹)—

O—

(CH₂)—

R²⁰ or —

(CHR¹⁹)—

O—

(CH₂)—

(CH₂)—

O—

R²⁰;

—

(CH═

CH)—

R²¹;

—

(CR²²R²³)—

C(═

O)—

O—

R²⁶, —

(CR²²R²³)—

(CR²⁴R²⁵)—

C(═

O)—

O—

R²⁶, —

(CR²²R²³)—

(CR²⁴R²⁵)—

(CH₂)—

C(═

O)—

O—

R²⁶ or —

(CR²²R²³)—

O—

(CR²⁴R²⁵)—

C(═

O)—

O—

R²⁶;

—

(CHR²⁷)—

O—

C(═

O)—

R²⁸;

—

CH[(CH₂)R²⁹][NH—

S(═

O)₂—

R³⁰];

—

CH[(CH₂)R³¹][NH—

C(═

O)—

O—

R³²];

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, sec-pentyl, 3-pentyl, —

(CH₂)—

(CH₂)—

(C(CH₃)₃), n-hexyl, 2-hexyl, 3-hexyl, n-heptyl, 2-heptyl, 3-heptyl, 4-heptyl and n-octyl;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, pyrrolidinyl, piperidinyl and adamantyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of —

C(═

O)—

CH₃, —

C(═

O)—

C₂H₅, —

C(═

O)—

C(CH₃)₃ and phenyl;

or

a group selected from the group consisting of phenyl, naphthyl, 2H-chromenyl, thiophenyl, furanyl, pyrazolyl, triazolyl, pyridinyl, [1,2,3]-thiadiazolyl, [2,1,3]-benzoxadiazolyl, [1,2,3]-benzoxadiazolyl, oxazolyl and isoxazolyl, wherein said group optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

CN, —

CF₃, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃, —

O—

CH₂—

CH₂—

CH₂—

CH₃, —

NO₂, —

O—

CF₃, —

S—

CF₃, —

S—

CF₂H, —

S—

CFH₂, —

S—

CH₃, —

S—

C₂H₅, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, —

C(CH₃)₂—

C₂H₅, n-hexyl, n-heptyl, —

NH—

C(═

O)—

CH₃, —

NH—

C(═

O)—

C₂H₅, —

NH—

CH₃, —

NH—

C₂H₅, —

NH—

CH(CH₃)₂, —

NH—

C(CH₃)₃, —

N(CH₃)₂, —

N(C₂H₅)₂, —

N(CH₃)(C₂H₅), —

S(═

O)₂—

NH₂, phenyl, —

O-phenyl, —

O-benzyl and benzyl;

wherein the cyclic moiety of the phenyl, —

O-phenyl, —

O-benzyl and benzyl groups optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl and Br;

R⁹ and R¹⁰ each independently denote a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

R¹¹, R¹³, R¹⁵, R¹⁷, R¹⁹, R²², R²³, R²⁴, R²⁵ and R²⁶ each independently denote hydrogen or a group selected from the group consisting of methyl, ethyl and n-propyl;

R¹², R²⁸ and R³², mutually independently, in each case denote a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

R¹⁴ denotes

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, tetrahydrofuranyl, tetrahydrothiophenyl and tetrahydropyranyl;

or

a phenyl group which may be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of F, Cl and Br;

R¹⁶ denotes a group selected from the group consisting of phenyl and naphthyl, wherein the group may in each case be substituted with 1, 2, 3, 4 or 5 substituents mutually independently selected from the group consisting of F, Cl and Br;

R¹⁸ denotes a 7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl group;

R²⁰ denotes

a group selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl and tert-butyl;

a group selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl;

wherein the group may in each case be substituted with a substituent selected from the group consisting of —

(CH₂)—

C(═

O)—

OH and —

C(═

O)—

OH;

or

a phenyl group which optionally may be substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of F, Cl, Br, —

O—

CH₃, —

O—

C₂H₅, —

O—

CH(CH₃)₂, —

O—

CH₂—

CH₂—

CH₃, —

O—

C(CH₃)₃ and —

O—

CH₂—

CH₂—

CH₂—

CH₃;

R²¹ denotes a phenyl group which may be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of F, Cl, and Br;

R²⁷ denotes a phenyl group;

R²⁹ denotes a phenyl group;

R³⁰ denotes a phenyl group which optionally may be substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, and tert-butyl; and

R³¹ denotes an indolyl group.

19. A compound as claimed in claim 1 selected from the group consisting of

[1] 3-(4-methylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid pentafluorophenylamide

[2] 3-(3-bromobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (2,5-dichlorophenyl)amide

[3] 2-oxo-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid benzylamide

[4] 3-(3,5-dimethylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (tetrahydrofuran-2-ylmethyl)amide

[5] 3-(3-bromobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (2-methoxyethyl)amide

[6] 3-(3-bromobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (2-methoxyphenyl)amide

[7] 3-(3,5-dimethylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (3-acetylphenyl)amide

[8] 3-benzyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid o-tolylamide

[9] 3-{[3-(3-bromobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioyl]amino}butanoic acid ethyl ester

[10] 3-naphthalen-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid allylamide

[11] 3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid benzylamide

[12] 3-biphenyl-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (1-phenylethyl)amide

[13] 3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (4-ethoxyphenyl)amide

[14] 3-(3-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (3,5-dichlorophenyl)amide

[15] 3-(3-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (3-trifluoromethylphenyl)amide

[16] 3-(3-bromobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid benzylamide

[17] 3-(2-methoxy-5-nitrobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (tetrahydrofuran-2-ylmethyl)amide

[18] 3-biphenyl-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-8-carbothioic acid phenylamide

[19] 3-(3-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid cyclohexylmethylamide

[20] 3-(2-fluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid (3-acetylphenyl)amide

[21] 3-(2-methoxy-5-nitrobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid cyclohexylmethylamide

[22] 3-(3-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid 4-chlorobenzylamide

[23] 3-(2-methoxy-5-nitrobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbothioic acid benzylamide

[24] 3-(2-fluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-ethoxyphenyl)amide

[25] 3-biphenyl-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (2,5-dichlorophenyl)amide

[26] 3-(2-methoxy-5-nitrobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (2,5-difluorophenyl)amide

[27] 3-(4-methylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-methyl-3-nitrophenyl)amide

[28] 3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid 4-fluorobenzylamide

[29] 3-(3-bromobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (2,5-difluorophenyl)amide

[30] 4-[(3-naphthalen-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbonyl)amino]benzoic acid ethyl ester

[31] 2-oxo-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-chloro-3-trifluoromethylphenyl)amide

[32] 3-(2-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (2,5-difluorophenyl)amide

[33] 3-benzyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (3-cyanophenyl)amide

[34] 3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-methyl-3-nitrophenyl)amide

[35] 3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (3-methoxyphenyl)amide

[36] 3-(4-methylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid 3,4-dichlorobenzylamide

[37] 3-benzyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-chloro-3-trifluoromethylphenyl)amide

[38] 2-oxo-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (3-cyanophenyl)amide

[39] 3-benzyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-methoxyphenyl)amide

[40] 2-oxo-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-methyl-3-nitrophenyl)amide

[41] 3-(4-iodobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-butoxyphenyl)amide

[42] 3-(3-bromobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid 3,4-dichlorobenzylamide

[43] 3-benzyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (1-phenylethyl)amide

[44] 3-naphthalen-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid 3,4-dichlorobenzylamide

[45] 3-(4-methylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid phenethylamide

[46] 2-oxo-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (3-methoxyphenyl)amide

[47] 3-(4-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-methoxyphenyl)amide

[48] 2-oxo-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (1-naphthalen-1-yl-ethyl)amide

[49] 2-oxo-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid phenethylamide

[50] 3-(4-iodobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-methyl-3-nitrophenyl)amide

[51] 3-(2-methoxy-5-nitrobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (3-cyanophenyl)amide

[52] 3-naphthalen-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (4-methoxyphenyl)amide

[53] 3-{[3-(4-methylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbonyl]amino}benzoic acid ethyl ester

[54] 2-oxo-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (1-naphthalen-1-yl-ethyl)amide

[55] 3-naphthalen-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (2,5-dimethoxyphenyl)amide

[56] 3-(4-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (3-acetylphenyl)amide

[57] 3-biphenyl-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid phenethylamide

[58] 3-(4-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (5-chloro-2-methoxyphenyl)amide

[59] 3-{[2-oxo-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decane-8-carbonyl]amino}benzoic acid ethyl ester

[60] 3-benzyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (3-fluorophenyl)amide

[61] 3-{[3-(3-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbonyl]amino}benzoic acid ethyl ester

[62] 3-biphenyl-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (3-methoxyphenyl)amide

[63] 3-(2-methoxy-5-nitrobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylic acid (1-naphthalen-1-yl-ethyl)amide

[64] {2-[3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-2-oxoethoxy}acetic acid

[65] 4-[3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-3,3-dimethyl-4-oxobutanoic acid

[66] [2-[3-(3-bromobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-1-(1H-indol-3-ylmethyl)-2-oxoethyl]carbamic acid tert-butyl ester

[67] 5-[3-(2-fluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-3-methyl-5-oxopentanoic acid

[68] 3,3-dimethyl-5-[3-(4-methylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-5-oxopentanoic acid

[69] 5-[3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-3-methyl-5-oxopentanoic acid

[70] {2-oxo-2-[2-oxo-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]ethoxy}acetic acid

[71] (1-{2-[3-(2-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-2-oxoethyl}cyclopentyl)acetic acid

[72] (1-{2-[3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-2-oxoethyl}cyclopentyl)acetic acid

[73] 5-(3-biphenyl-2-ylmethyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl)-3-methyl-5-oxopentanoic acid

[75] N-[4-(3,5-dichlorophenylsulfamoyl)phenyl]-2-[3-(4-methylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]acetamide

[76] N-(2,5-dimethyl-2H-pyrazol-3-yl)-2-[3-(2-methoxy-5-nitrobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]acetamide

[80] N-(3-cyano-4-methylthiophen-2-yl)-2-[3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]acetamide

[85] 2-[2-oxo-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-N-(4-phenyl-5-trifluoromethylthiophen-3-yl)acetamide

[86] 2-[3-(2-fluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-N-(4-phenyl-thiazolyl-2-yl)acetamide

[87] 2-[2-oxo-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-N-(4-trifluoromethoxyphenyl)acetamide

[91] N-{4-[3-(3-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbonyl]phenyl}acetamide

[92] 8-(4-ethoxybenzoyl)-3-(4-methylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[93] 3-[3-(4-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-3-oxopropionic acid methyl ester

[94] 2-[8-(2,4-difluorobenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[95] 8-(3-dimethylaminobenzoyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[96] N-{4-[3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbonyl]phenyl}acetamide

[97] 8-(4-bromobenzoyl)-3-(4-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[98] 4-[8-(adamantane-1-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[99] 3-(3,5-dimethylbenzyl)-8-(2-ethylsulfanylpyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[100] 3-(3-bromobenzyl)-8-(4-chlorobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[101] 8-[3-(2-chlorophenyl)-5-methylisoxazole-4-carbonyl]-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[102] 3-(3-bromobenzyl)-8-(4-ethylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[103] 8-(4-butoxybenzylsulfonyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[104] 8-(biphenyl-4-carbonyl)-3-(3-bromobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[105] acetic acid 2-[3-(3,5-dimethylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-2-oxo-1-phenylethyl ester

[106] 4-[2-oxo-8-(2-phenylcyclopropanecarbonyl)-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[107] 8-(2,5-dimethoxybenzylsulfonyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[108] 8-(2-chlorobenzoyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[109] 3-(3-bromobenzyl)-8-(4-nitrobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[110] N-{1-benzyl-2-[3-(3-cyanobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-2-oxoethyl}-4-methylbenzylsulfonamide

[111] 8-(2-ethylsulfanylpyridine-3-carbonyl)-3-(3-methoxybenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[112] 8-(2,4-dimethoxybenzoyl)-3-(3-methoxybenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[113] 3-(3,5-dimethylbenzyl)-8-[2-(3-methoxyphenyl)acetyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[114] 3-(3,5-dimethylbenzyl)-8-(4-methoxy-2,3,6-trimethylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[115] 4-[8-(biphenyl-4-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[116] 8-(2-chlorobenzylsulfonyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[117] 8-(benzo[1,2,5]oxadiazole-5-carbonyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[118] 8-(biphenyl-4-carbonyl)-3-(4-iodobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[119] 3-(3,5-dimethylbenzyl)-8-(pyridine-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[120] 8-(6-chloropyridine-3-carbonyl)-3-naphthalen-2-ylmethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[121] 3-(3-bromobenzyl)-8-(2-ethylsulfanylpyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[122] 3-(3,5-dimethylbenzyl)-8-(5-methylisoxazole-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[123] 3-(2-methoxy-5-nitrobenzyl)-8-pentanoyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[124] 8-(4-bromobenzoyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[125] 8-(5-tert-butyl-2-methylfuran-3-carbonyl)-3-(2-methoxy-5-nitrobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[126] 8-(3-chlorobenzoyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[127] 8-(2-ethylsulfanylpyridine-3-carbonyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[128] 3-(3,5-dimethylbenzyl)-8-(isoxazole-5-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[129] 3-(3-bromobenzyl)-8-(pyridine-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[130] 3-(3,5-dimethylbenzyl)-8-(thiophene-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[131] 8-(3-chloro-4-fluorobenzoyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[132] 8-(2,6-difluoro-3-methylbenzoyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[133] 4-[3-(3-bromobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl]-4-oxobutanoic acid methyl ester

[134] 3-[8-(2-ethylbutyryl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[135] 3-[8-(3-bromobenzylsulfonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[136] 3-(3,4-difluorobenzyl)-8-(4-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[137] 3-(3-bromobenzyl)-8-(3,5-dimethoxybenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[138] 8-(3-dimethylaminobenzoyl)-3-(2-methoxy-5-nitrobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[139] 8-(2,6-dichlorobenzoyl)-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[140] 3-(2-methoxy-5-nitrobenzyl)-8-(2-phenoxypyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[141] 8-[2-(3-methoxyphenyl)acetyl]-3-naphthalen-2-ylmethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[142] 4-{2-oxo-8-[2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl]-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl}benzonitrile

[143] 8-(3,5-bis-trifluoromethylbenzoyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[144] 3-(3-bromobenzyl)-8-(2-phenoxypyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[145] 3-(2-methoxy-5-nitrobenzyl)-8-[2-(3-methoxyphenyl)acetyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[146] 3-(3,4-difluorobenzyl)-8-(2-phenoxypyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[147] 3-[8-(4-bromo-3-methylbenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[148] 3-(3-bromobenzyl)-8-(4-propylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[149] 3-biphenyl-2-ylmethyl-8-(3-chlorobenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[150] 8-[2-(3,4-dimethoxyphenyl)acetyl]-3-(2-methoxy-5-nitrobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[151] 2-[8-(2-chloro-4-nitrobenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[152] 3-[2-oxo-8-(2,4,6-trimethylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[153] 3-benzyl-8-(4-fluorobenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[154] 3-(4-fluorobenzyl)-8-(toluene-4-sulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[155] 4-[2-oxo-8-(toluene-4-sulfonyl)-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[156] 3-(2-fluorobenzyl)-8-(toluene-4-sulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[157] 3-(3,4-difluorobenzyl)-8-(toluene-4-sulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[158] 3-(4-tert-butylbenzyl)-8-(toluene-4-sulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[159] 8-(toluene-4-sulfonyl)-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[160] 2-[3-(4-fluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-8-sulfonyl]benzoic acid methyl ester

[161] 2-[3-(3-methoxybenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-8-sulfonyl]benzoic acid methyl ester

[162] 2-[3-(3-bromobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-8-sulfonyl]benzoic acid methyl ester

[163] 3-benzyl-8-(2-methanesulfonylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[164] 8-(2-methanesulfonylbenzylsulfonyl)-3-(2-methoxy-5-nitrobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[165] 3-(4-methylbenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-sulfonic acid dimethylamide

[166] 4-[8-(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-ylmethanesulfonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[167] 3-(4-fluorobenzyl)-8-(4-methoxybenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[168] 3-(4-methylbenzyl)-8-(4-trifluoromethoxybenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[169] 8-(4-trifluoromethoxybenzylsulfonyl)-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[170] 8-(propane-1-sulfonyl)-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[171] 3-(2-methoxy-5-nitrobenzyl)-8-(4-propylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[172] 3-biphenyl-2-ylmethyl-8-(4-propylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[173] 8-(3-bromobenzylsulfonyl)-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[174] 8-(3-bromobenzylsulfonyl)-3-(3-bromobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[175] 2-{8-[4-(1,1-dimethylpropyl)benzylsulfonyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl}benzonitrile

[176] 3-benzyl-8-[4-(1,1-dimethylpropyl)benzylsulfonyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[177] 8-[4-(1,1-dimethylpropyl)benzylsulfonyl]-3-(4-iodobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[178] 8-[4-(1,1-dimethylpropyl)benzylsulfonyl]-3-(2-methoxy-5-nitrobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[179] 8-[4-(1,1-dimethylpropyl)benzylsulfonyl]-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[180] 3-biphenyl-2-ylmethyl-8-[4-(1,1-dimethylpropyl)benzylsulfonyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[181] 8-(4,5-dichlorothiophene-2-sulfonyl)-3-(3-methoxybenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[182] 8-(4,5-dichlorothiophene-2-sulfonyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[183] 3-(3-bromobenzyl)-8-(4,5-dichlorothiophene-2-sulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[184] 2-[8-(4-methoxy-2,3,6-trimethylbenzylsulfonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[185] 3-(2-fluorobenzyl)-8-(4-methoxy-2,3,6-trimethylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[186] 3-(4-tert-butylbenzyl)-8-[2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[187] 8-(butane-1-sulfonyl)-3-(3-methoxybenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[188] 3-(4-methylbenzyl)-8-(thiophene-2-sulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[189] 8-(4-chloro-2,5-dimethylbenzylsulfonyl)-3-(4-methylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[190] 3-benzyl-8-(4-chloro-2,5-dimethylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[191] 8-(4-chloro-2,5-dimethylbenzylsulfonyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[192] 3-biphenyl-2-ylmethyl-8-(4-chloro-2,5-dimethylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[193] 8-(4-chloro-2,5-dimethylbenzylsulfonyl)-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[194] 3-(4-fluorobenzyl)-8-(2-trifluoromethylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[195] 3-(3-methoxybenzyl)-8-(2-trifluoromethylbenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[196] 3-benzyl-8-(2-methyl-5-nitrobenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[197] 3-(4-tert-butylbenzyl)-8-(2-methyl-5-nitrobenzylsulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[198] 3-(4-tert-butylbenzyl)-8-(toluene-3-sulfonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[199] 8-(furan-2-carbonyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[200] 3-(3-bromobenzyl)-8-(furan-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[201] 4-[8-(naphthalene-1-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[202] 3-(3,4-difluorobenzyl)-8-(naphthalene-1-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[203] 3-(3-bromobenzyl)-8-(naphthalene-1-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[204] 2-[8-(3-nitrobenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[205] 4-[8-(3-nitrobenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[206] 3-(3-bromobenzyl)-8-(3,5-difluorobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[207] 8-(2-benzyloxy-acetyl)-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[208] 8-(2-chlorobenzoyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[209] 8-(2-chlorobenzoyl)-3-(4-iodobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[210] 8-(2-chlorobenzoyl)-3-(2-methoxy-5-nitrobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[211] 3-biphenyl-2-ylmethyl-8-(2-chlorobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[212] 8-(2,6-dichlorobenzoyl)-3-naphthalen-2-ylmethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[213] 3-(4-tert-butylbenzyl)-8-(2,6-dichlorobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[214] 3-(3-bromobenzyl)-8-(2,6-dichlorobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[215] 8-(2,6-dichlorobenzoyl)-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[216] 2-[8-(2-methylbenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[217] 8-(2-methylbenzoyl)-3-(4-methylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[218] 8-(2-methylbenzoyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[219] 3-(2-methoxy-5-nitrobenzyl)-8-(2-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[220] 3-(3,4-difluorobenzyl)-8-(2-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[221] 8-(2-methylbenzoyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[222] 8-(2-methylbenzoyl)-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[223] 8-(3-bromobenzoyl)-3-(4-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[224] 8-(3-bromobenzoyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[225] 8-(3-bromobenzoyl)-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[226] 8-(3-bromobenzoyl)-3-(3,4-difluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[227] 8-(3-bromobenzoyl)-3-naphthalen-2-ylmethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[228] 8-(3-bromobenzoyl)-3-(4-tert-butylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[229] 3-benzyl-8-(3-fluorobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[230] 8-(3-fluorobenzoyl)-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[231] 3-(3,4-difluorobenzyl)-8-(3-fluorobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[232] 8-(3-fluorobenzoyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[233] 3-(3-bromobenzyl)-8-(3-fluorobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[234] 8-(3-chlorobenzoyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[235] 3-benzyl-8-(3-chlorobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[236] 4-[8-(3,4-dichlorobenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[237] 3-(4-iodobenzyl)-8-(3-methoxybenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[238] 3-(2-fluorobenzyl)-8-(3-methoxybenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[239] 3-(4-tert-butylbenzyl)-8-(3-methoxybenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[240] 3-benzyl-8-(3-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[241] 3-(2-methoxy-5-nitrobenzyl)-8-(3-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[242] 3-(4-tert-butylbenzyl)-8-(3-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[243] 8-(3-methylbenzoyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[244] 3-(3,4-difluorobenzyl)-8-(2-phenyl-butyryl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[245] 3-benzyl-8-[3-(2-chlorophenyl)-5-methylisoxazole-4-carbonyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[246] 4-[8-(2,3-dichlorobenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[247] 8-[2-(4-chlorophenyl)acetyl]-3-(3,4-difluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[248] 3-biphenyl-2-ylmethyl-8-[2-(4-chlorophenyl)acetyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[249] 8-[2-(4-chlorophenyl)acetyl]-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[250] 3-(4-tert-butylbenzyl)-8-[3-(2-chlorophenyl)acryloyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[251] 3-biphenyl-2-ylmethyl-8-[3-(2-chlorophenyl)acryloyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[252] 3-(3-bromobenzyl)-8-[3-(2-chlorophenyl)acryloyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[253] 4-[8-(2,3-difluorobenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[254] 8-(2,3-difluorobenzoyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[255] 8-(2,3-difluorobenzoyl)-3-(4-iodobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[256] 2-[2-oxo-8-(2-propylpentanoyl)-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[257] 3-(3,4-difluorobenzyl)-8-(2-propylpentanoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[258] 8-(2-chloro-4-nitrobenzoyl)-3I-(4-methylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[259] 8-(2-chloro-4-nitrobenzoyl)-3I-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[260] 3-(4-tert-butylbenzyl)-8-(2-chloro-4-nitrobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[261] 8-(2-chloro-4-nitrobenzoyl)-3I-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[262] 3-biphenyl-2-ylmethyl-8-(2-chloro-4-nitrobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[263] 3-(3-bromobenzyl)-8-(2-chloro-4-nitrobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[264] 8-(2-chloro-4-nitrobenzoyl)-3I-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[265] 8-(2-chloropyridine-3-carbonyl)-3-(4-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[266] 2-[8-(2-chloropyridine-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[267] 8-(2-chloropyridine-3-carbonyl)-3-(4-methylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[268] 8-(2-chloropyridine-3-carbonyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[269] 3-(3-methoxybenzyl)-8-(2-methylsulfanylpyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[270] 3-(4-methylbenzyl)-8-(2-methylsulfanylpyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[271] 3-(4-iodobenzyl)-8-(2-methylsulfanylpyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[272] 3-(3,4-difluorobenzyl)-8-(2-methylsulfanylpyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[273] 3-(4-tert-butylbenzyl)-8-(2-methylsulfanylpyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[274] 8-(2-methylsulfanylpyridine-3-carbonyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[275] 8-(2-ethylsulfanylpyridine-3-carbonyl)-3-(4-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[276] 3-[8-(2-ethylsulfanylpyridine-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[277] 2-[8-(2-ethylsulfanylpyridine-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[278] 8-(2-ethylsulfanylpyridine-3-carbonyl)-3-(4-methylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[279] 3-benzyl-8-(2-ethylsulfanylpyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[280] 8-(2-ethylsulfanylpyridine-3-carbonyl)-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[281] 4-[8-(6-chloropyridine-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[282] 8-(6-chloropyridine-3-carbonyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[283] 8-(6-chloropyridine-3-carbonyl)-3-(4-iodobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[284] 3-(4-tert-butylbenzyl)-8-(6-chloropyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[285] 3-biphenyl-2-ylmethyl-8-(6-chloropyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[286] 3-(3-methoxybenzyl)-8-(4-trifluoromethoxybenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[287] 3-(3,4-difluorobenzyl)-8-(4-trifluoromethoxybenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[288] 8-[3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl]-3-(4-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[289] 8-[3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl]-3-(3-methoxybenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[290] 8-[3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl]-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[291] 8-[3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl]-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[292] 3-(4-methylbenzyl)-8-(3-trifluoromethoxybenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[293] 3-(4-iodobenzyl)-8-(3-trifluoromethoxybenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[294] 3-(3,4-difluorobenzyl)-8-(3-trifluoromethoxybenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[295] 3-naphthalen-2-ylmethyl-8-(3-trifluoromethoxybenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[296] 4-[8-(isoxazole-5-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[297] 8-(isoxazole-5-carbonyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[298] 8-(isoxazole-5-carbonyl)-3-(2-methoxy-5-nitrobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[299] 3-(3-bromobenzyl)-8-(isoxazole-5-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[300] 2-[8-(2-chloro-6-fluorobenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[301] 4-[8-(2-chloro-6-fluorobenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[302] 8-(2-chloro-6-fluorobenzoyl)-3-(4-methylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[303] 3-biphenyl-2-ylmethyl-8-(2-chloro-6-fluorobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[304] 8-(2,5-dimethylfuran-3-carbonyl)-3-(3-methoxybenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[305] 4-[8-(2,5-dimethylfuran-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[306] 4-[8-(4-bromo-3-methylbenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[307] 8-(4-bromo-3-methylbenzoyl)-3-(4-methylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[308] 3-benzyl-8-(4-bromo-3-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[309] 8-(4-bromo-3-methylbenzoyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[310] 8-(4-bromo-3-methylbenzoyl)-3-(3,4-difluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[311] 8-(4-bromo-3-methylbenzoyl)-3-(4-tert-butylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[312] 3-biphenyl-2-ylmethyl-8-(4-bromo-3-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[313] 8-(4-bromo-3-methylbenzoyl)-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[314] 8-(2,6-difluoro-3-methylbenzoyl)-3-(3-methoxybenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[315] 2-[8-(2,6-difluoro-3-methylbenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[316] 4-[8-(2,6-difluoro-3-methylbenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[317] 8-(2,6-difluoro-3-methylbenzoyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[318] 8-(2,6-difluoro-3-methylbenzoyl)-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[319] 8-(2-chloro-6-fluoro-3-methylbenzoyl)-3-(4-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[320] 8-(2-chloro-6-fluoro-3-methylbenzoyl)-3-(3-methoxybenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[321] 8-(2-chloro-6-fluoro-3-methylbenzoyl)-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[322] 3-biphenyl-2-ylmethyl-8-(6-chloro-2-fluoro-3-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[323] 3-benzyl-8-(3-difluoromethylsulfanylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[324] 8-(3-difluoromethylsulfanylbenzoyl)-3-naphthalen-2-ylmethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[325] 8-(3-difluoromethylsulfanylbenzoyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[326] 3-(3-bromobenzyl)-8-(3-difluoromethylsulfanylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[327] 3-[8-(3-chloro-2-fluorobenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[328] 8-(3-chloro-2-fluorobenzoyl)-3-(4-iodobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[329] 8-(3-chloro-2-fluorobenzoyl)-3-naphthalen-2-ylmethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[330] 3-(3-methoxybenzyl)-8-(4-trifluoromethylsulfanylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[331] 2-[2-oxo-8-(4-trifluoromethylsulfanylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[332] 4-[2-oxo-8-(4-trifluoromethylsulfanylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[333] 3-(4-iodobenzyl)-8-(4-trifluoromethylsulfanylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[334] 3-naphthalen-2-ylmethyl-8-(4-trifluoromethylsulfanylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[335] 3-(4-trifluoromethylbenzyl)-8-(4-trifluoromethylsulfanylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[336] 8-(2-chloro-5-trifluoromethylbenzoyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[337] 8-(2-chloro-5-trifluoromethylbenzoyl)-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[338] 8-(2-chloro-5-trifluoromethylbenzoyl)-3-(3,4-difluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[339] 8-(2,3-difluoro-4-methylbenzoyl)-3-(3-methoxybenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[340] 4-[8-(2,3-difluoro-4-methylbenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[341] 3-benzyl-8-(2,3-difluoro-4-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[342] 8-(2,3-difluoro-4-methylbenzoyl)-3-(4-iodobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[343] 3-(3,4-difluorobenzyl)-8-(2,3-difluoro-4-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[344] 8-(2,3-difluoro-4-methylbenzoyl)-3-naphthalen-2-ylmethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[345] 3-biphenyl-2-ylmethyl-8-(2,3-difluoro-4-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[346] 3-(3-bromobenzyl)-8-(2,3-difluoro-4-methylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[347] 3-benzyl-8-[2-(2-methoxyethoxy)acetyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[348] 3-(2-fluorobenzyl)-8-[2-(2-methoxyethoxy)acetyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[349] 3-(3,4-difluorobenzyl)-8-[2-(2-methoxyethoxy)acetyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[350] 3-(4-tert-butylbenzyl)-8-[2-(2-methoxyethoxy)acetyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[351] 8-[2-(2-methoxyethoxy)acetyl]-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[352] 8-(1-acetylpiperidine-4-carbonyl)-3-(3,4-difluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[353] 4-{8-[2-(3-chlorophenoxy)acetyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl}benzonitrile

[354] 8-[2-(3-chlorophenoxy)acetyl]-3-(3,4-difluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[355] 3-(3-bromobenzyl)-8-[2-(3-chlorophenoxy)acetyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[356] 8-[2-(3-chlorophenoxy)acetyl]-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[357] 4-[3-(3-methoxybenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbonyl]benzylsulfonamide

[358] N-{4-[3-(3,4-difluorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carbonyl]phenyl}acetamide

[359] 8-(3-dimethylaminobenzoyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[360] 3-(4-tert-butylbenzyl)-8-(3-dimethylaminobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[361] 3-(3-bromobenzyl)-8-(3-dimethylaminobenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[362] 3-(4-methylbenzyl)-8-(4-phenoxybutyryl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[363] 8-(4-phenoxybutyryl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[364] 3-(2-fluorobenzyl)-8-(4-phenoxybutyryl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[365] 8-(2,3-dimethylbenzoyl)-3-(4-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[366] 3-[8-(2,3-dimethylbenzoyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[367] 8-(2,3-dimethylbenzoyl)-3-(3,5-dimethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[368] 8-(2,3-dimethylbenzoyl)-3-(4-methylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[369] 8-(2,3-dimethylbenzoyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[370] 8-(2,3-dimethylbenzoyl)-3-(2-methoxy-5-nitrobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[371] 8-(2,3-dimethylbenzoyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[372] 3-biphenyl-2-ylmethyl-8-(2,3-dimethylbenzoyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[373] 4-[8-(5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[374] 3-benzyl-8-(5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[375] 3-(3,4-difluorobenzyl)-8-(5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[376] 8-(5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carbonyl)-3-naphthalen-2-ylmethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[377] 3-biphenyl-2-ylmethyl-8-(5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[378] 3-(4-tert-butylbenzyl)-8-[3-(2,6-dichlorophenyl)-5-methylisoxazole-4-carbonyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[379] 3-[2-oxo-8-(2-phenoxypyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[380] 2-[2-oxo-8-(2-phenoxypyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[381] 3-(4-fluorobenzyl)-8-(pyridine-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[382] 3-(3-methoxybenzyl)-8-(pyridine-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[383] 3-(3,5-dimethylbenzyl)-8-(pyridine-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[384] 2-[2-oxo-8-(pyridine-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[385] 3-(2-fluorobenzyl)-8-(pyridine-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[386] 3-(3,4-difluorobenzyl)-8-(pyridine-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[387] 3-biphenyl-2-ylmethyl-8-(pyridine-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[388] 4-[8-(3-chlorothiophene-2-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[389] 8-(3-chlorothiophene-2-carbonyl)-3-(3,4-difluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[390] 3-biphenyl-2-ylmethyl-8-(3-chlorothiophene-2-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[391] 8-[1-(4-chlorophenyl)-5-trifluoromethyl-1H-pyrazole-4-carbonyl]-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[392] 8-[1-(4-chlorophenyl)-5-trifluoromethyl-1H-pyrazole-4-carbonyl]-3-(3,4-difluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[393] 8-[1-(4-chlorophenyl)-5-trifluoromethyl-1H-pyrazole-4-carbonyl]-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[394] 3-(4-tert-butylbenzyl)-8-(5-tert-butyl-2-methyl-2H-pyrazole-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[395] 3-[8-(5-methylisoxazole-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[396] 3-(3,5-dimethylbenzyl)-8-(5-methylisoxazole-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[397] 2-[8-(5-methylisoxazole-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[398] 4-[8-(5-methylisoxazole-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[399] 3-benzyl-8-(5-methylisoxazole-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[400] 3-(3,4-difluorobenzyl)-8-(5-methylisoxazole-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[401] 3-biphenyl-2-ylmethyl-8-(5-methylisoxazole-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[402] 8-(4-methyl[1,2,3]thiadiazole-5-carbonyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[403] 3-(4-tert-butylbenzyl)-8-(4-methyl[1,2,3]thiadiazole-5-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[404] 8-(4-methyl[1,2,3]thiadiazole-5-carbonyl)-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[405] 4-[2-oxo-8-(1-phenyl-5-propyl-1H-pyrazole-4-carbonyl)-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[406] 3-(3,4-difluorobenzyl)-8-(1-phenyl-5-propyl-1H-pyrazole-4-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[407] 3-naphthalen-2-ylmethyl-8-(1-phenyl-5-propyl-1H-pyrazole-4-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[408] 8-(1-phenyl-5-propyl-1H-pyrazole-4-carbonyl)-3-(4-trifluoromethylsulfanylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[409] 3-[8-(2-chloropyridine-4-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[410] 8-(2-chloropyridine-4-carbonyl)-3-(3-methoxybenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[411] 8-(5-tert-butyl-2-methylfuran-3-carbonyl)-3-(4-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[412] 3-[8-(5-tert-butyl-2-methylfuran-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[413] 2-[8-(5-tert-butyl-2-methylfuran-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[414] 4-[8-(5-tert-butyl-2-methylfuran-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[415] 8-(5-tert-butyl-2-methylfuran-3-carbonyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[416] 8-(5-tert-butyl-2-methylfuran-3-carbonyl)-3-naphthalen-2-ylmethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[417] 3-biphenyl-2-ylmethyl-8-(5-tert-butyl-2-methylfuran-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[418] 3-(3-bromobenzyl)-8-(5-tert-butyl-2-methylfuran-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[419] 8-(benzo[1,2,5]oxadiazole-5-carbonyl)-3-(3,4-difluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[420] 8-(benzo[1,2,5]oxadiazole-5-carbonyl)-3-(4-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[421] 3-[8-(2-methyl-6-trifluoromethylpyridine-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[422] 2-[8-(2-methyl-6-trifluoromethylpyridine-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[423] 4-[8-(2-methyl-6-trifluoromethylpyridine-3-carbonyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-ylmethyl]benzonitrile

[424] 8-(2-methyl-6-trifluoromethylpyridine-3-carbonyl)-3-(2-trifluoromethylbenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[425] 3-(3,4-difluorobenzyl)-8-(2-methyl-6-trifluoromethylpyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[426] 3-(3-bromobenzyl)-8-(2-methyl-6-trifluoromethylpyridine-3-carbonyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[427] 8-(6-chloro-2H-chromene-3-carbonyl)-3-(3,4-difluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[428] 8-(2-chloropyridine-4-carbonyl)-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[429] 8-(2-chloropyridine-4-carbonyl)-3-naphthalen-2-ylmethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[430] 8-acetyl-3-(2-fluorobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

[431] 8-acetyl-3-(3-bromobenzyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one and

[432] 3-(2-methoxy-5-nitrobenzyl)-8-(3-phenoxypropyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one;

and pharmaceutically acceptable salts thereof.

20. A pharmaceutical composition comprising a compound as claimed in claim 1 and at least one physiologically acceptable auxiliary substance.