Systems and methods for detecting and compensating for changes in posture during ischemia detection using an implantable medical device

• US 8,155,731 B1
• Filed: 10/18/2006
• Issued: 04/10/2012
• Est. Priority Date: 10/18/2006
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Bharmi, Rupinder
• Primary Examiner(s): Patel, Niketa
• Assistant Examiner(s): EL-KAISSI, HIBA CARINE
• Application Number:
  US11/550,751
• Time in Patent Office: 2,001 Days
• Field of Search: 607/9, 607 17- 19, 600/517, 600/509
• US Class Current: 600/509
• CPC Class Codes: A61B 5/1116 Determining posture transitions
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61B 5/721 using a separate sensor to detect motion or using motion information derived from signals other than the physiological signal to be measured
• CPC Class Codes: A61B 5/7242 using integration

Abstract

Techniques are described for detecting changes in posture; detecting cardiac ischemia while accounting for changes in posture; and delivering therapy or warning signals in response thereto using the implantable medical device. In one example, the device detects variations in the electrical cardiac signals indicative of a possible episode of cardiac ischemia. Changes in patient posture are detected as well using an accelerometer or similar device. Then, an episode of cardiac ischemia is detected based on the variations in the cardiac signals while distinguishing variations due to changes in posture. In another example, the device instead detects changes in posture based on transient changes in morphological features of electrical cardiac signals.

Claims

1. A method for use with an implantable medical device for detecting changes in posture in a patient in which the device is implanted, comprising:

sensing an electrical cardiac signal within the patient using the device;

obtaining atrial paced depolarization integral (PDI) measurements of the cardiac signal affected by one or more of patient posture, patient activity and cardiac ischemia;

determining an atrial PDI baseline level corresponding to a first posture of a patient;

detecting for a significant transient variation period in atrial PDI measurements during which the peak-to-peak values of the PDI measurements fluctuate between two to three times the peak-to-peak values of the atrial PDI measurements defining the first posture atrial PDI baseline level;

detecting for a transient decay period subsequent to a significant transient variation period during which the transient PDI measurements gradually decay to a subsequent baseline atrial PDI corresponding to a second posture of the patient;

detecting, using a microprocessor, a significant change in patient posture when the significant transient variation period is detected, the transient decay period is detected and a difference between the initial atrial PDI baseline and the subsequent atrial PDI baseline exceeds a predetermined threshold indicative of a significant posture change; and

detecting, using the microprocessor, patient activity without a significant change in posture when the significant transient variation period is detected and the difference between the initial atrial PDI baseline and the subsequent atrial PDI baseline does not exceed the predetermined threshold.

2. The method of claim 1 further including controlling at least one device function based on the determination of a change in posture.

3. The method of claim 2 wherein the at least one device function includes controlling a pacing rate in response to a change in posture.

4. The method of claim 1 further comprising:

detecting variations in electrical cardiac signals indicative of a possible episode of a medical condition; and

detecting an episode of the medical condition based on the variations in the cardiac signals while distinguishing variations due to changes in posture.

5. The method of claim 4 wherein the medical condition is cardiac ischemia.

6. The method of claim 5 wherein detecting variations in the cardiac signals indicative of a possible episode of a cardiac ischemia includes detecting selected variations in one or more of the elevation, width, maximum slope, and peak amplitude of P-waves, QRS-complexes, T-waves and intervals therebetween.

7. The method of claim 6 wherein detecting selected variations in the cardiac signals includes detecting variations in an ST-segment elevation.

8. The method of claim 5 further including the step of controlling therapy in response to the detection of an episode of cardiac ischemia.

9. The method of claim 5 further including the step of generating a warning signal in response to detection of an episode of a medical condition.

10. The method of claim 1 wherein the baseline levels are represented by one or more of a standard deviation in the PDI or a peak-to-peak variability in the PDI.

11. The method of claim 1 wherein the baseline levels are represented by one or more of an average or a mean PDI level.

12. The method of claim 1 further including

detecting a posture change corroborating parameter including one or more of heart rate, blood pressure and oxygen consumption;

and

corroborating the determination that a change in posture occurred using the corroborating parameter.

13. The method of claim 1 wherein the difference between the initial atrial PDI baseline and the subsequent atrial PDI baseline corresponds to a change in mean atrial PDI.

14. The method of claim 1 wherein the difference between the initial atrial PDI baseline and the subsequent atrial PDI baseline corresponds to a change in standard deviation of atrial PDI.

15. A system for use with an implantable medical device for implant within a patient, comprising:

a cardiac signal detection unit configured to sense an electrical cardiac signal within the patient and to obtain atrial paced depolarization integral (PDI) measurements of the cardiac signal affected by one or more of patient posture, patient activity and cardiac ischemia from the cardiac signal; and

a posture change detection unit configured to determine an atrial PDI baseline level corresponding to a first posture of a patient, to detect for a significant transient variation period in the atrial PDI measurements during which the peak-to-peak values of the PDI measurements fluctuate between two to three times the peak-to-peak values of the atrial PDI measurements defining the first-posture atrial PDI baseline level, to detect for a transient decay period subsequent to a significant transient variation period during which the transient PDI measurements gradually decay to a subsequent baseline atrial PDI corresponding to a second posture of the patient, to detect a significant change in patient posture when the significant transient variation period is detected, the transient decay period is detected and a difference between the initial atrial PDI baseline and the subsequent atrial PDI baseline exceeds a predetermined threshold indicative of a significant posture change, and to detect patient activity without a significant change in posture when the significant transient variation period is detected and the difference between the initial atrial PDI baseline and the subsequent atrial PDI baseline does not exceed the predetermined threshold.

16. A system for use with an implantable medical device for implant within a patient, comprising:

means for sensing an intracardiac electrogram (IEGM) signal within the patient;

means for obtaining atrial paced depolarization integral (PDI) measurements of the cardiac signal affected by one or more of patient posture, patient activity and cardiac ischemia from the IEGM;

means for determining an atrial PDI baseline level corresponding to a first posture of a patient;

means for detecting for a significant transient variation in atrial PDI measurements during which the peak-to-peak values of the PDI measurements fluctuate between two to three times the peak-to-peak values of the atrial PDI measurements defining the first-posture atrial PDI baseline level;

means for detecting for a transient decay period subsequent to a significant transient variation period during which the transient PDI measurements gradually decay to a subsequent baseline atrial PDI corresponding to a second posture of the patient;

means for detecting a significant change in patient posture when the significant transient variation period is detected, the transient decay period is detected and a difference between the initial atrial PDI baseline and the subsequent atrial PDI baseline exceeds a predetermined threshold indicative of a significant posture change; and

means for detecting patient activity without a significant change in posture when the significant transient variation period is detected and the difference between the initial atrial PDI baseline and the subsequent atrial PDI baseline does not exceed the predetermined threshold.