Retrograde atrial sensing for identifying sub-threshold atrial pacing

• US 8,155,741 B2
• Filed: 11/21/2008
• Issued: 04/10/2012
• Est. Priority Date: 05/25/2005
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Bohn, Derek D., Gandhi, Rajesh K.
• Primary Examiner(s): Layno, Carl H.
• Assistant Examiner(s): Heller, Tammie K
• Application Number:
  US12/275,833
• Publication Number:
  US 20090076564A1
• Time in Patent Office: 1,236 Days
• Field of Search: 607/27, 607/28
• US Class Current: 607/27
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold
• CPC Class Codes: A61N 1/3714 Atrial capture

Abstract

Atrial capture threshold testing is performed in accordance with an atrial capture threshold testing schedule. Monitoring for retrograde P-waves occurs at least during times other than times during which scheduled atrial capture threshold testing is performed. In response to detecting a retrograde P-wave indicative of sub-threshold atrial pacing during monitoring, an unscheduled atrial capture threshold test is performed and pacing of the atrium is adjusted based on the unscheduled atrial capture threshold test.

Claims

1. A method, comprising:

performing atrial capture threshold testing in accordance with an atrial capture threshold testing schedule;

monitoring for retrograde P-waves at least during times other than times during which scheduled atrial capture threshold testing is performed;

detecting, during the monitoring, a retrograde P-wave indicative of sub-threshold atrial pacing;

performing an unscheduled atrial capture threshold test in response to detecting the retrograde P-wave;

adjusting pacing of the atrium based on the unscheduled atrial capture threshold test; and

generating a retrograde P-wave template indicative of retrograde conduction, wherein detecting the retrograde P-wave during monitoring comprises identifying the retrograde P-wave using the generated retrograde P-wave template.

2. The method of claim 1, comprising mitigating pacemaker mediated tachycardia in response to performing the unscheduled atrial capture threshold test.

3. The method of claim 1, wherein adjusting pacing of the atrium comprises adjusting delivery of one or more pacing pulses to the atrium based on the unscheduled atrial capture threshold test.

4. The method of claim 1, wherein adjusting pacing of the atrium comprises adjusting a pacing pulse amplitude or pacing pulse width.

5. The method of claim 1, comprising confirming presence of the retrograde P-wave prior to adjusting pacing of the atrium.

6. The method of claim 1, wherein detecting the retrograde P-wave comprises determining at least one of the amplitude or timing of an atrial response.

7. The method of claim 1, wherein detecting the retrograde P-wave comprises sensing an atrial response during a post ventricular atrial refractory period.

8. A method, comprising:

performing atrial capture threshold testing in accordance with an atrial capture threshold testing schedule;

monitoring for retrograde P-waves at least during times other than times during which scheduled atrial capture threshold testing is performed;

detecting, during the monitoring, a retrograde P-wave indicative of sub-threshold atrial pacing;

performing an unscheduled atrial capture threshold test in response to detecting the retrograde P-wave;

adjusting pacing of the atrium based on the unscheduled atrial capture threshold test; and

generating a retrograde P-wave template indicative of retrograde conduction, wherein performing the unscheduled atrial capture threshold test comprises identifying a retrograde P-wave using the generated retrograde P-wave template.

9. A method, comprising:

performing atrial capture threshold testing in accordance with an atrial capture threshold testing schedule;

monitoring for retrograde P-waves at least during times other than times during which scheduled atrial capture threshold testing is performed;

detecting, during the monitoring, a retrograde P-wave indicative of sub-threshold atrial pacing;

performing an unscheduled atrial capture threshold test in response to detecting the retrograde P-wave; and

adjusting pacing of the atrium based on the unscheduled atrial capture threshold test;

wherein detecting the retrograde P-wave comprises determining at least one of the frequency content or slew rate of an atrial response.

10. A system for use with a patient, comprising:

a plurality of implantable electrodes configured for cardiac electrical activity sensing and cardiac pacing;

a housing configured for implantation in the patient;

detection circuitry provided in the housing and configured to detect retrograde P-waves indicative of sub-threshold atrial pacing, and

a controller provided in the housing and configured to perform atrial capture threshold testing in accordance with an atrial capture threshold testing schedule, the controller configured to perform an unscheduled atrial capture threshold test in response to the detection circuitry detecting a retrograde P-wave during a time other than a time during which scheduled atrial capture threshold testing is performed, the controller configured to adjust atrial pacing based on the unscheduled atrial capture threshold test;

wherein the controller is configured to coordinate generation of a retrograde P-wave template indicative of retrograde conduction, and the detection circuitry is configured to detect the retrograde P-wave using the retrograde P-wave template.

11. The system of claim 10, wherein the controller is configured to mitigate pacemaker mediated tachycardia in response to performing the unscheduled atrial capture threshold test.

12. The system of claim 10, wherein the controller is configured to adjust delivery of one or more pacing pulses to the atrium based on the unscheduled atrial capture threshold test.

13. The system of claim 10, wherein the controller is configured to adjust a pacing pulse amplitude or pacing pulse width.

14. The system of claim 10, wherein the controller is configured to confirm presence of the retrograde P-wave prior to adjusting pacing of the atrium.

15. The system of claim 10, wherein the detection circuitry is configured to detect the retrograde P-wave by determining at least one of the frequency content, slew rate, amplitude, or timing of an atrial response.

16. The system of claim 10, comprising communication circuitry, wherein the controller communicates with a patient-external system using the communication circuitry.

17. The system of claim 10, comprising communication circuitry, wherein the controller communicates with a patient-external system using the communication circuitry, the patient-external system configured to produce trend data using data associated with performance of the unscheduled atrial capture threshold test.