System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation

• US 8,155,750 B2
• Filed: 07/24/2009
• Issued: 04/10/2012
• Est. Priority Date: 07/24/2008
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Jaax, Kristen, Lane, Courtney, Moffitt, Michael, DiGiore, Andrew, Pierre, Mark, Bradley, Kerry, Baldwin, Gregory
• Primary Examiner(s): Manuel, George
• Assistant Examiner(s): Wieland, Robert
• Application Number:
  US12/509,340
• Publication Number:
  US 20100023090A1
• Time in Patent Office: 991 Days
• Field of Search: 607/17, 607/45, 607/59, 607/116
• US Class Current: 607/59
• CPC Class Codes: A61N 1/36132 using patient feedback
• CPC Class Codes: A61N 1/36146 specified by the stimulation parameters
• CPC Class Codes: A61N 1/37235 Aspects of the external programmer
• CPC Class Codes: A61N 1/37264 Changing the program; Upgrading firmware

Abstract

A method and programmer for programming a neurostimulation device are provided. The method comprises varying a first stimulation parameter under user control, automatically varying a second stimulation parameter, generating a plurality of stimulation parameter sets from the varied first and second stimulation parameters, outputting a pulsed electrical waveform from the neurostimulation device between a plurality of electrodes in accordance with the stimulation parameter sets, such that neural tissue is stimulated without undergoing neurological accommodation that would otherwise occur if the second stimulation parameter were not varied, and programming the neurostimulation device with a new set of stimulation parameters based on a result of the neural tissue stimulation The programmer comprises a user interface capable of receiving an input from a user, a processor configured for performing the previous steps, and output circuitry configured for transmitting the stimulation parameter sets and the new stimulation parameter set to the neurostimulation device.

Claims

1. A method of programming a neurostimulation device, comprising:

varying a first stimulation parameter under user control;

automatically varying a second stimulation parameter as the first stimulation parameter is varied under user control;

generating a plurality of stimulation parameter sets from the varied first and second stimulation parameters;

outputting a pulsed electrical waveform from the neurostimulation device between a plurality of electrodes in accordance with the plurality of stimulation parameter sets, such that neural tissue is stimulated without undergoing neurological accommodation that would otherwise occur if the second stimulation parameter were not varied; and

programming the neurostimulation device with a new set of stimulation parameters based on a result of the neural tissue stimulation.

2. The method of claim 1, wherein the first stimulation parameter is an electrode combination.

3. The method of claim 1, wherein the first stimulation parameter is a fractionalized electrode combination.

4. The method of claim 3, wherein the fractionalized electrode combination is varied by gradually shifting current between anodic ones of the electrodes or gradually shifting current between cathodic ones of the electrodes.

5. The method of claim 1, wherein the second stimulation parameter is pseudo-randomly or randomly varied.

6. The method of claim 1, wherein the second stimulation parameter is an electrical pulse parameter.

7. The method of claim 6, wherein the electrical pulse parameter is a pulse amplitude.

8. The method of claim 7, wherein pulse amplitude is varied by both increasing and decreasing the amplitude of the pulses.

9. The method of claim 6, wherein the electrical pulse parameter is a pulse width.

10. The method of claim 7, wherein the pulse amplitude and a pulse width for each pulse are inversely varied relative to each other.

11. The method of claim 10, wherein the pulse amplitude and pulse width for each pulse are varied, such that the pulsed electrical waveform is maintained within a predetermined range of a strength-duration curve for the neural tissue.

12. The method of claim 6, wherein the electrical pulse parameter is a pulse shape.

13. The method of claim 6, wherein the electrical pulse parameter is a burst rate.

14. The method of claim 1, wherein the second stimulation parameter is an electrode combination.

15. The method of claim 1, wherein the neural tissue is spinal cord tissue.

16. A programmer for a neurostimulation device, comprising:

a user interface capable of receiving an input from a user;

a processor configured for varying a first stimulation parameter in response to the user input, automatically varying a second stimulation parameter as the first stimulation parameter is varied, generating a plurality of stimulation parameter sets from the varied first and second stimulation parameters, and programming the neurostimulation device with a new set of stimulation parameters; and

output circuitry configured for transmitting the plurality of stimulation parameter sets and the new stimulation parameter set to the neurostimulation device.

17. The programmer of claim 16, wherein the first stimulation parameter is an electrode combination.

18. The programmer of claim 17, wherein the first stimulation parameter is a fractionalized electrode combination.

19. The programmer of claim 18, wherein the fractionalized electrode combination is varied by gradually shifting current between anodic ones of the electrodes or gradually shifting current between cathodic ones of the electrodes.

20. The programmer of claim 16, wherein the processor is configured for pseudo-randomly or randomly varying the second stimulation parameter.

21. The programmer of claim 16, wherein the second stimulation parameter is an electrical pulse parameter.

22. The programmer of claim 21, wherein the electrical pulse parameter is a pulse amplitude.

23. The programmer of claim 22, wherein pulse amplitude is varied by both increasing and decreasing the pulse amplitude.

24. The programmer of claim 21, wherein the electrical pulse parameter is a pulse width.

25. The programmer of claim 22, wherein the processor is configured for inversely varying the pulse amplitude and a pulse width for each pulse relative to each other.

26. The programmer of claim 25, wherein the processor is configured for varying the pulse amplitude and pulse width for each pulse, such that the pulsed electrical waveform is maintained within a predetermined range of a strength-duration curve.

27. The programmer of claim 21, wherein the electrical pulse parameter is a pulse shape.

28. The programmer of claim 21, wherein the electrical pulse parameter is a burst rate.

29. The programmer of claim 16, wherein the second stimulation parameter is an electrode combination.

30. The programmer of claim 16, wherein the user interface comprises an actuator, and wherein the processor is configured for generating the plurality of stimulation parameter sets in response to actuation of the actuator.

31. The programmer of claim 16, wherein the output circuitry is telemetry circuitry configured for wirelessly transmitting the plurality of stimulation parameter sets and the new stimulation parameter set to the neurostimulation device.