Method and device for performing cooling-or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation

• US 8,157,794 B2
• Filed: 10/30/2007
• Issued: 04/17/2012
• Est. Priority Date: 03/31/1998
• Status: Expired due to Fees

• Current Assignee: Zoll Circulation Incorporated (Asahi Kasei Corporation)
• Original Assignee: Innercool therapies Incorporated (Taxus Cardium Pharmaceuticals Group, Inc.)
• Inventors: Dobak, John D. III, Kramer, Hans W., Yon, Steven A.
• Primary Examiner(s): Gibson, Roy
• Application Number:
  US11/978,888
• Publication Number:
  US 20080300585A1
• Time in Patent Office: 1,631 Days
• Field of Search: 606 20- 23, 607/96, 607104-106
• US Class Current: 606/22
• CPC Class Codes: A61B 18/02 by cooling, e.g. cryogenic techniques devices for cooling specific reflex points of the body within cell-life limits A61H39/06
• CPC Class Codes: A61B 2017/22002 preventing restenosis
• CPC Class Codes: A61B 2017/22054 with two balloons
• CPC Class Codes: A61B 2018/00023 closed, i.e. without wound contact by the fluid
• CPC Class Codes: A61B 2018/0022 Balloons
• CPC Class Codes: A61B 2018/0212 using an instrument inserted into a body lumen, e.g. catheter
• CPC Class Codes: A61B 2018/0262 using a circulating cryogenic fluid
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities

Abstract

The present invention provides an enhanced method and device to inhibit or reduce the rate of restenosis following angioplasty or stent placement. The invention involves placing a balloon tipped catheter in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place from a balloon angioplasty. A fluid such as a perfluorocarbon may be flowed into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. The catheter may also be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon is in contact with at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium.

Claims

1. A method of reducing restenosis after angioplasty in a blood vessel, comprising:

inserting a catheter into a blood vessel, the catheter having a balloon;

inflating the balloon with a perfluorocarbon such that an exterior surface of the balloon is in contact with at least a partial inner perimeter of the blood vessel, the perfluorocarbon having a temperature in the range of about −

10°

C. to −

50°

C., wherein the balloon comprises dual balloons; and

providing a heat transfer fluid in a volume between the dual balloons.

2. The method of claim 1, further comprising the step of disposing the catheter at a desired location using at least one marker band.

3. The method of claim 1, further comprising flowing the perfluorocarbon into the balloon using a supply lumen and exhausting the perfluorocarbon from the balloon using a return lumen.

4. The method of claim 1, wherein the heat transfer fluid includes a contrast media fluid.

5. The method of claim 1, further comprising disposing the catheter such that at least a portion of the balloon is in a coronary artery.

6. The method of claim 1, further comprising disposing the catheter such that at least a portion of the balloon is in a carotid artery.