FAIMS having a displaceable electrode for on/off operation

• US 8,158,932 B2
• Filed: 04/16/2010
• Issued: 04/17/2012
• Est. Priority Date: 04/16/2010
• Status: Active Grant

• Current Assignee: Thermo Finnigan LLC (Thermo Fisher Scientific Incorporated)
• Original Assignee: Thermo Finnigan LLC (Thermo Fisher Scientific Incorporated)
• Inventors: Belford, Michael W., Dunyach, Jean-Jacques, Hardman, Mark E.
• Primary Examiner(s): Johnston, Phillip A
• Assistant Examiner(s): Purinton, Brooke
• Application Number:
  US12/762,176
• Publication Number:
  US 20110253890A1
• Time in Patent Office: 732 Days
• Field of Search: 250/280, 250/281, 250/282, 250/287, 250/288, 250/289, 250/290, 250/291, 250/292
• US Class Current: 250/287
• CPC Class Codes: G01N 27/624 Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]

Abstract

A system for analyzing ions comprises: an ion source; a FAIMS cell comprising: (a) a gas inlet; (b) an outer electrode having a generally concave inner surface and comprising: (i) an ion inlet operable to receive the ions from the ion source and a carrier gas from the gas inlet; and (ii) an ion outlet; and (c) an inner electrode having a conduit therethrough and having a generally convex outer surface that is disposed in a spaced-apart and facing arrangement relative to the inner surface of the outer electrode for defining an ion separation region therebetween; and a mass analyzer for mass analyzing ions transmitted by the FAIMS cell through the ion outlet, wherein the inner electrode is moveable between a first position and a second position, the first position facilitating movement of the ions through the ion separation region, the second position facilitating movement of the ions through the conduit.

Claims

1. A system for analyzing ions, comprising:

an ion source for generating ions;

a High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) cell comprising;

(a) a gas inlet;

(b) an outer electrode having a generally concave inner surface and comprising;

(i) an ion inlet operable to receive the ions from the ion source and a carrier gas from the gas inlet; and

(ii) an ion outlet; and

(c) an inner electrode having a conduit therethrough and having a generally convex outer surface comprising a cylindrical surface having a cylindrical axis that is disposed in a spaced-apart and facing arrangement relative to the inner surface of the outer electrode for defining an ion separation region therebetween; and

a mass analyzer for mass analyzing ions transmitted by the FAIMS cell through the ion outlet,

wherein the inner electrode is moveable between a first position and a second position, the first position facilitating movement of the ions through the ion separation region, the second position facilitating movement of the ions through the conduit.

2. A system for analyzing ions as recited in claim 1, further comprising a gap between the FAIMS cell and the mass analyzer for atmospheric pressure exhaust of the carrier gas.

3. A system for analyzing ions as recited in claim 1, further comprising:

a housing of the mass analyzer comprising at least one evacuated chamber;

a gas-tight coupling between the FAIMS cell and the at least one evacuated chamber; and

at least one vacuum port coupled to the at least one evacuated chamber for maintaining the at least one evacuated chamber and the ion separation region at sub-atmospheric pressure.

4. A system for analyzing ions as recited in claim 3, wherein the sub-atmospheric pressure is within the range 100-600 torr.

5. A system for analyzing ions as recited in claim 3, further comprising:

an ion transfer tube for transporting the ions and other charged particles from an ion source to the ion inlet; and

a heater coupled to the ion transfer tube for heating the ion transfer tube.

6. A system for analyzing ions as recited in claim 1, wherein a movement of the inner electrode between the first and second positions is such that a point on the cylindrical surface undergoes a spiral motion.

7. A system for analyzing ions as recited in claim 1, wherein a movement of the inner electrode between the first and second positions is such that a point on the cylindrical surface undergoes a displacement parallel to the cylindrical axis.

8. A system for analyzing ions as recited in claim 1, wherein the cylindrical surface comprises at least one circumferential surface feature that partially inhibits migration of ions in parallel to the cylindrical axis within the ion separation region.

9. A system for analyzing ions as recited in claim 1, further comprising at least one gasket or bushing that seals an aperture of the conduit of the inner electrode to either the ion inlet or the ion outlet when the inner electrode is disposed in the second position.

10. A system for analyzing ions, comprising:

an ionization chamber;

an atmospheric pressure ion source within the ionization chamber for generating ions;

a first reduced pressure chamber;

an ion transfer tube having a first end disposed within the ionization chamber for receiving ions from the ion source and a second end disposed within the first reduced pressure chamber;

a heater in thermal contact with the ion transfer tube applying heat to the ion transfer tube;

a carrier gas conduit for introducing a flow of carrier gas into the ion transfer tube;

a High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) cell within the first reduced pressure chamber comprising;

(a) an outer electrode having a generally concave inner surface and comprising;

(i) an ion inlet operable to receive the ions and the carrier gas from the second end of the ion transfer tube; and

(ii) an ion outlet; and

(b) an inner electrode having a conduit therethrough and having a generally convex outer surface comprising a cylindrical surface having a cylindrical axis that is disposed in a spaced-apart and facing arrangement relative to the inner surface of the outer electrode for defining an ion separation region therebetween;

a mass analyzer for mass analyzing ions transmitted by the FAIMS cell through the ion outlet; and

a housing of the mass analyzer comprising at least one evacuated chamber fluidically coupled to the ion outlet of the FAIMS cell,

wherein the inner electrode is moveable between a first position and a second position, the first position facilitating movement of the ions through the ion separation region, the second position facilitating movement of the ions through the conduit.

11. A system for analyzing ions, comprising:

an ion source for generating ions;

a High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) cell comprising;

(a) a gas inlet;

(b) an outer electrode having a generally concave inner surface and comprising;

(i) an ion inlet operable to receive the ions from the ion source and a carrier gas from the gas inlet; and

(ii) an ion outlet; and

(c) an inner electrode having a conduit therethrough and a generally convex outer surface comprising a cylindrical surface having a cylindrical axis that is disposed in a spaced-apart and facing arrangement relative to the inner surface of the outer electrode for defining an ion separation region therebetween;

a mass analyzer for mass analyzing ions transmitted by the FAIMS cell through the ion outlet, the mass analyzer separated from the FAIMS cell by a gap therebetween;

a gas-tight coupling between the FAIMS cell and the mass analyzer within the gap;

and at least one vacuum port coupled to the mass analyzer for maintaining the mass analyzer and the FAIMS ion separation region at sub-atmospheric pressure,

wherein the inner electrode is moveable between a first position and a second position, the first position facilitating movement of the ions through the ion separation region, the second position facilitating movement of the ions through the conduit.

12. A system for analyzing ions as recited in claim 11, further comprising:

an ion transfer tube for transporting the ions and other charged particles from an ion source to the ion inlet; and

a heater coupled to the ion transfer tube for heating the ion transfer tube.

13. A system for analyzing ions as recited in claim 11, wherein the sub-atmospheric pressure is within the range 100-600 torr.