Microneedle arrays with ATR sensor
First Claim
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1. A sensor for optical determination of the concentration of an analyte in a body fluid, comprising:
- a needle arrangement including a plurality of needles, each needle having a distal end, a proximal end, and a hollow space extending from the distal end to the proximal end, the distal end being configured for lancing and entry of fluid;
a chamber into which the proximal end opens and in which the fluid can be collected; and
a window which is at least partially permeable to infrared radiation and is in contact with the chamber, the chamber forming an interspace between the needle arrangement and the window.
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Abstract
A sensor is described for optically determining the concentration of an analyte in a body fluid. This sensor comprises a needle arrangement which has at least one hollow needle having a hollow space extending from the distal end to the proximal end, the distal end of which is suitable for lancing. The proximal end of the needle opens into a chamber in which liquid that enters through the distal end of the needle can be collected. A window which is at least partially permeable to infrared radiation is in direct contact with the chamber.
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Citations
50 Claims
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1. A sensor for optical determination of the concentration of an analyte in a body fluid, comprising:
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a needle arrangement including a plurality of needles, each needle having a distal end, a proximal end, and a hollow space extending from the distal end to the proximal end, the distal end being configured for lancing and entry of fluid; a chamber into which the proximal end opens and in which the fluid can be collected; and a window which is at least partially permeable to infrared radiation and is in contact with the chamber, the chamber forming an interspace between the needle arrangement and the window. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A fluid sampling and analyte concentration measurement system, comprising:
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a chamber in which fluid can be collected; a plurality of needles, each needle having a distal end, a proximal end, and a hollow space extending therebetween, the distal end being configured for lancing and entry of fluid, the proximal end opening into the chamber; a window which is at least partially permeable to infrared radiation positioned adjacent the chamber, the chamber forming an interspace between the needles and the window; a light source configured to transmit radiation into the window; a detector positioned on a different side of the window than the light source and configured to generate absorption measurement signals; and an evaluation unit coupled to the detector and configured to calculate the concentration of an analyte in the fluid from the absorption measurement signals. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A method of determining concentration of analyte in a body fluid sample of a patient, comprising:
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inserting distal ends of a plurality of needles into the patient'"'"'s skin and drawing body fluid into the needles, the needles being coupled to a chamber with a proximal end of each needle being in fluid communication with the chamber; transferring the body fluid from the needle into the chamber, the chamber being positioned adjacent a window and forming an interspace between the needles and the window, and wherein the body fluid contacts the window; directing light through the window; detecting the light that passes through the window; and determining analyte concentration from the detected light. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A sensor for determining the concentration of an analyte in a body fluid, comprising:
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a chamber in which fluid can be collected; a plurality of needles, each needle having a distal end, a proximal end, and a hollow space extending therebetween, the distal end being configured for lancing and entry of body fluid, the proximal end opening into the chamber; a window positioned adjacent the chamber and having a surface configured to contact body fluid collected in the chamber, the chamber forming an interspace between the needles and the window, the window configured for receiving radiation, reflecting the radiation from interior surfaces of the window, and transmitting the radiation from the window. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49, 50)
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Specification