Autofluorescent imaging and target ablation
First Claim
Patent Images
1. A device comprising:
- an untethered ingestible mass configured to rotate, wherein the untethered ingestible mass includes;
a first optical energy source configured to provide electromagnetic energy selected to stimulate an auto-fluorescent response in one or more target cells in a digestive tract;
a sensor configured to detect the auto-fluorescent response;
control circuitry coupled to the sensor and responsive to identify a target area; and
a second energy source responsive to the control circuitry and configured to emit energy selected to at least partially ablate the target area, anda third optical energy source alignable with the first optical energy source and configured to provide targeting electromagnetic energy;
wherein the third optical energy source is configured to provide one or more outputs to the control circuitry; and
wherein the one or more outputs include a visual indication of an orientation of the electromagnetic energy selected to induce the auto-fluorescent response.
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Abstract
Apparatus, devices, methods, systems, computer programs and computing devices related to autofluorescent imaging and ablation are disclosed.
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Citations
53 Claims
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1. A device comprising:
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an untethered ingestible mass configured to rotate, wherein the untethered ingestible mass includes; a first optical energy source configured to provide electromagnetic energy selected to stimulate an auto-fluorescent response in one or more target cells in a digestive tract; a sensor configured to detect the auto-fluorescent response; control circuitry coupled to the sensor and responsive to identify a target area; and a second energy source responsive to the control circuitry and configured to emit energy selected to at least partially ablate the target area, and a third optical energy source alignable with the first optical energy source and configured to provide targeting electromagnetic energy;
wherein the third optical energy source is configured to provide one or more outputs to the control circuitry; and
wherein the one or more outputs include a visual indication of an orientation of the electromagnetic energy selected to induce the auto-fluorescent response. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A method for detecting and ablating a target area in a digestive tract comprising:
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providing to a subject a rotating untethered ingestible mass; providing from the untethered ingestible mass electromagnetic energy selected to induce an auto-fluorescent response in one or more target cells in the digestive tract; detecting the auto-fluorescent response using a sensor in the untethered ingestible mass; identifying the target area at least partially based on an analysis of the detected auto-fluorescent response using control circuitry coupled to the sensor; providing from the untethered ingestible mass energy configured to at least partially ablate the identified target area; and providing from the untethered ingestible mass targeting electromagnetic energy alignable with the electromagnetic energy selected to induce the auto-fluorescent response;
wherein the targeting electromagnetic energy provides a visual indication of an orientation of the electromagnetic energy selected to induce the auto-fluorescent response;
wherein the targeting electromagnetic energy is configured to provide one or more outputs to the control circuitry; and
wherein the one or more outputs include a visual indication of an orientation of the electromagnetic energy selected to induce the auto-fluorescent response. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53)
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Specification