Refillable reservoir lead systems
First Claim
1. A method of treating epilepsy in a subject comprising:
- at least partially implanting a medical electrical lead system in a brain of a subject, wherein the lead system comprises a lead body comprising a first lumen and a refillable reservoir comprising a second lumen that is in fluid communication with the first lumen and wherein the reservoir is removed from a distal end of the lead body and situated under a surface of the subject'"'"'s head; and
detecting epileptiform activity or an electrographic seizure in the brain of the subject using at least one signal acquired with the medical electrical lead system,delivering at least one bioactive agent from reservoir and the first lumen so that the at least one bioactive agent moves passively from the reservoir to a region of the brain of the subject upon such detection.
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Accused Products
Abstract
Medical electrical lead systems and related methods are described. The medical electrical lead systems may be configured to be at least partially implanted in a body of a subject. Some variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and a lumen extending at least partially therebetween, at least one electrode in the proximity of the distal end of the lead body, and a reservoir in fluid communication with the lumen, where the reservoir is located at a position removed from the distal end of the lead body. Certain variations of the medical electrical lead systems may comprise a lead body comprising a proximal end and a distal end and first and second lumens extending at least partially therebetween, and at least one electrode in the proximity of the distal end of the lead body.
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Citations
16 Claims
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1. A method of treating epilepsy in a subject comprising:
- at least partially implanting a medical electrical lead system in a brain of a subject, wherein the lead system comprises a lead body comprising a first lumen and a refillable reservoir comprising a second lumen that is in fluid communication with the first lumen and wherein the reservoir is removed from a distal end of the lead body and situated under a surface of the subject'"'"'s head; and
detecting epileptiform activity or an electrographic seizure in the brain of the subject using at least one signal acquired with the medical electrical lead system, delivering at least one bioactive agent from reservoir and the first lumen so that the at least one bioactive agent moves passively from the reservoir to a region of the brain of the subject upon such detection. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
- at least partially implanting a medical electrical lead system in a brain of a subject, wherein the lead system comprises a lead body comprising a first lumen and a refillable reservoir comprising a second lumen that is in fluid communication with the first lumen and wherein the reservoir is removed from a distal end of the lead body and situated under a surface of the subject'"'"'s head; and
Specification