Devices, systems and methods for flow-compensating pump-injector synchronization
First Claim
1. A control device for a solvent delivery system, the control device being configured to, upon receipt of a first start run signal,provide second start run signals to a dominant flow pump and a non-dominant flow pump to perform a first forced-transfer operation to deliver compressed solvents into a fluid stream;
- and thenafter a predetermined time delay elapses following receipt of the second start run signals, provide a second forced-transfer signal the dominant flow pump to perform a second forced-transfer operation to provide a corrective flow of compressed solvent into the fluid stream to counter a pressure drop associated with introduction of an analyte into the fluid stream.
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Accused Products
Abstract
Systems, devices, and methods to mitigate the pressure disturbance associated with the injection of low-pressure analyte samples into a high-pressure HPLC fluid stream, to enhance chromatographic performance related to retention time and reproducibility. The preferred embodiment coordinates the injection run with active pressure control of a binary solvent delivery system to virtually eliminate the customary pressure drop when the low-pressure loop is brought on line. An additional benefit that enhances reproducibility is accomplished by forcing a consistent timing relationship between the injection run, the mechanical position of the delivery pump pistons, and the start and subsequent gradient delivery.
19 Citations
18 Claims
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1. A control device for a solvent delivery system, the control device being configured to, upon receipt of a first start run signal,
provide second start run signals to a dominant flow pump and a non-dominant flow pump to perform a first forced-transfer operation to deliver compressed solvents into a fluid stream; - and then
after a predetermined time delay elapses following receipt of the second start run signals, provide a second forced-transfer signal the dominant flow pump to perform a second forced-transfer operation to provide a corrective flow of compressed solvent into the fluid stream to counter a pressure drop associated with introduction of an analyte into the fluid stream. - View Dependent Claims (2, 3, 4, 5)
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6. A system comprising:
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an autosample injector operable to inject an analyte into a fluid stream; and a dominant flow pump; a non-dominant flow pump; a control device in communication with the autosample injector, the dominant flow pump, and the non-dominant flow pump, wherein the control device is configured to, upon receipt of a start run signal from the autosample injector, signal the dominant flow pump and the non-dominant flow pump to perform a first forced-transfer operation to deliver compressed solvents into the fluid stream, and then after a predetermined time delay elapses following receipt of the start run signal, signal the dominant flow pump to perform a second forced-transfer operation to provide a corrective flow of compressed solvent into the fluid stream to counter a pressure drop associated with introduction of the analyte into the fluid stream. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14)
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15. A method comprising the steps of:
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receiving a start run signal, and, in response; providing a first signal to a dominant flow pump and a non-dominant flow pump to perform a first forced-transfer operation to deliver compressed solvents into a fluid stream; and
thenafter a predetermined time delay elapses following receipt of the start run signal, providing a second signal to the dominant flow pump to perform a second forced-transfer operation to provide a corrective flow of compressed solvent into the fluid stream to counter a pressure drop associated with introduction of an analyte into the fluid stream. - View Dependent Claims (16, 17, 18)
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Specification