Combined cryotherapy and brachytherapy device and method

• US 8,162,812 B2
• Filed: 03/12/2010
• Issued: 04/24/2012
• Est. Priority Date: 03/12/2009
• Status: Active Grant

• Current Assignee: IceCure Medical Ltd.
• Original Assignee: IceCure Medical Ltd.
• Inventors: Shai, Eyal, Berzak, Nir
• Primary Examiner(s): Marmor, II, Charles A
• Assistant Examiner(s): Burk, Catherine E
• Application Number:
  US12/722,845
• Publication Number:
  US 20100234670A1
• Time in Patent Office: 774 Days
• Field of Search: 600 1- 8, 606 20- 26
• US Class Current: 600/2
• CPC Class Codes: A61B 18/02 by cooling, e.g. cryogenic techniques devices for cooling specific reflex points of the body within cell-life limits A61H39/06
• CPC Class Codes: A61B 2018/0262 using a circulating cryogenic fluid
• CPC Class Codes: A61N 5/1015 Treatment of resected cavities created by surgery, e.g. lumpectomy

Abstract

Combined brachytherapy and ablation devices and methods. A combined brachytherapy and cryotherapy method, includes: inserting an ablation device into tissue of a subject; ablating tissue within an ablation zone of the device; detaching and removing a first part of the device while leaving a second part of the device in the tissue, the first part contacting the ablation zone; and inserting a brachytherapy rod into the second part of the device when the second part is detached from the first part, the brachytherapy rod connected to base at one end and retaining at least one radioactive seed at an opposing end, the brachytherapy rod configured and dimensioned so that when it is inserted into the device up to the base, the at least one radioactive seed is in the ablation zone.

Claims

1. A combined cryotherapy and brachytherapy method, comprising:

ablating tissue in an ablation zone of a cryoprobe inserted into a tumor, the cryoprobe extending into the tumor and having a closed end;

separating the cryoprobe from a handle;

fixing a location of the cryoprobe; and

positioning at least one radioactive element in the cryoprobe, after the ablating,

wherein, in the positioning, the radioactive element is guided into the tumor by the cryoprobe, without contacting the tumor.

2. The method of claim 1, wherein the positioning comprises providing a rod that is adapted and configured to be removably insertable into the cryoprobe, and the at least one radioactive element is disposed at an end of the rod.

3. The method of claim 1, wherein, in the positioning, the at least one radioactive element is a single seed that is positioned at a substantial center of the ablation zone.

4. The method of claim 1, wherein, in the positioning, the radioactive element extends along a portion of a length of the cryoprobe and is positioned through at least a substantial center of the ablation zone.

5. The method of claim 1, wherein the cryoprobe includes an inner tube usable for an inflow of cryogenic liquid or gas and wherein, in the positioning, the radioactive element is inserted into the cryoprobe through the inner tube.

6. The method of claim 1, wherein the cryoprobe includes an outer shaft and, wherein, in the positioning, the at least one radiation element is inserted into the cryoprobe through the outer shaft.

7. The method of claim 6, wherein the radioactive element is a plurality of radioactive elements that are located at specified locations with respect to a distal end of a rod.

8. A device, comprising:

a handle;

a cryoprobe that

(i) has a proximal end that is selectively detachable from the handle,

(ii) has an ablation zone when activated, and

(iii) has a closed, pointed tip at a distal end, the tip adapted and configured to pierce a tumor so that at least a portion of the cryoprobe may be inserted into the tumor such that the tumor is disposed within the ablation zone;

a brachytherapy rod adapted and configured to be removably insertable into at least a portion of the cryoprobe when it is detached from the handle, the rod having at least one radioactive seed at an end,

wherein the cryoprobe guides the brachytherapy rod in the tumor,

wherein both the cryoprobe and the brachytherapy rod may be in the tumor contemporaneously, and

wherein, when the brachytherapy rod is inserted into the cryoprobe, the at least one radioactive seed is disposed at a specified position in the ablation zone and in the tumor.

9. The device of claim 8, wherein the rod includes a base opposite the end and the base is configured and dimensioned so as to limit travel of the rod into the cryoprobe.

10. The device of claim 8, wherein the rod has a protrusion near a base opposite the end that limits travel of the rod into the cryoprobe.

11. The device of claim 8, wherein the cryoprobe includes an inner tube usable for an inflow of cryogenic liquid or gas, and wherein the brachytherapy rod is inserted into the cryoprobe through the inner tube.

12. The device of claim 8, wherein the cryoprobe includes an outer shaft, wherein only the outer shaft remains in the subject after the cryoprobe has been activated, and wherein the brachytherapy rod is inserted into the cryoprobe through the outer shaft.

13. The device of claim 8, wherein, when a portion of the cryoprobe is disposed in the tumor, neither the brachytherapy rod nor the radioactive seed contact the tumor.