Microneedle array patch
First Claim
1. A microneedle device comprising:
- one or more microneedles capable of penetrating the stratum corneum, each of said microneedles comprising an interior channel and a proximal end and a distal end; and
a plugging element for plugging one or more of said one or more microneedles, where said plugging element is disposed within the interior channel of one or more of said one or more microneedles;
wherein the plugging element is configured to be removed from the interior channel of the one or more of said one or more microneedles to allow delivery of material across a biological barrier, and wherein the one or more of said one or more microneedles are configured to deliver material only when the plugging element is removed from the interior channel.
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Accused Products
Abstract
Microneedle devices for transport of molecules, including drugs and biological molecules, across tissue, are provided. The microneedle devices permit drug delivery or removal of body fluids at clinically relevant rates across skin or other tissue barriers, with minimal or no damage, pain, or irritation to the tissue. Microneedles can be formed of biodegradable or non-biodegradable polymeric materials or metals. In a preferred embodiment, a microneedle device includes a plugging element comprising a platform including a plurality of microneedle plugs for preventing skin or other tissue barriers from entering the hollow microneedles. In another preferred embodiment, a microneedle device includes a plurality of bioerodible elements for temporarily plugging the hollow microneedles, thereby preventing skin or other tissue barriers from entering the hollow microneedles.
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Citations
15 Claims
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1. A microneedle device comprising:
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one or more microneedles capable of penetrating the stratum corneum, each of said microneedles comprising an interior channel and a proximal end and a distal end; and a plugging element for plugging one or more of said one or more microneedles, where said plugging element is disposed within the interior channel of one or more of said one or more microneedles; wherein the plugging element is configured to be removed from the interior channel of the one or more of said one or more microneedles to allow delivery of material across a biological barrier, and wherein the one or more of said one or more microneedles are configured to deliver material only when the plugging element is removed from the interior channel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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Specification