Methods and devices to create a chemically and/or mechanically localized pleurodesis

• US 8,163,034 B2
• Filed: 02/21/2008
• Issued: 04/24/2012
• Est. Priority Date: 05/11/2007
• Status: Expired due to Fees

• Current Assignee: Portaero, Inc
• Original Assignee: Portaero, Inc
• Inventors: Chang, Asia, Tanaka, Don
• Primary Examiner(s): ANDERSON, GREGORY A
• Application Number:
  US12/034,785
• Publication Number:
  US 20080281433A1
• Time in Patent Office: 1,524 Days
• Field of Search: 623/23.72, 128/200.24, 128/200.26, 128/207.16, 606/153, 606/151
• US Class Current: 623/23.72
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61M 2039/0252 for access to the lungs
• CPC Class Codes: A61M 2039/0276 for introducing or removing fluids into or out of the body
• CPC Class Codes: A61M 2039/0297 at least part of it being inflatable, e.g. for anchoring, sealing or removing
• CPC Class Codes: A61M 39/0247 Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body peritoneal dialysis catheters A61M1/285; tracheostomy devices A61M16/0465; measuring pressure within the body A61B5/03; colostomy devices A61F5/445; gastrotomy feeding tubes A61J15/0015; means for fixing a feeding tube outside of the body A61J15/0053

Abstract

A localized pleurodesis for lung devices created utilizing a combination of a mechanical component and a chemical component. The chemical component is utilized to create an acute adhesion between the visceral pleural membrane and parietal pleural membrane while the mechanical component is utilized to create a chronic adhesion.

Claims

1. A method of forming a local pleurodesis between parietal pleura and visceral pleura comprising the steps in any order of:

implanting a mechanical component comprising a mesh patch between the parietal pleura and the visceral pleura such that the mesh patch is in contact with the parietal pleura and the visceral pleura in a localized region;

creating an acute adhesion between the mesh patch and the parietal pleura and the visceral pleura in the localized region with a chemical adhesive; and

creating a fusion between the parietal pleura and the visceral pleura in the localized region with the mesh patch.

2. The method of claim 1, including:

delivering said mechanical component through a cannula in order to percutaneously access a thoracic cavity.

3. The method of claim 1, including:

delivering said mechanical component during a thoracotomy procedure.

4. The method of claim 1, including:

creating said acute adhesion with said chemical adhesive in order to provide enough stability at an implant location for an implantable structure to allow the mechanical component to create said fusion.

5. A localized pleurodesis method comprising:

(a) receiving a mesh patch adapted to induce tissue ingrowth;

(b) percutaneously inserting the mesh patch into a pleural cavity defined by a visceral membrane and a parietal membrane;

(c) securing the mesh patch against the visceral membrane and the parietal membrane at a selected localized region; and

(d) holding the mesh patch in apposition with both the parietal membrane and visceral membrane until the mesh patch induces a localized fusion between the parietal membrane and the visceral membrane at the selected localized region.

6. The method of claim 5, wherein step (c) comprises securing the mesh patch against the visceral membrane and the parietal membrane with a suture which passes through the mesh patch.

7. The method of claim 5, wherein step (c) comprises securing the mesh patch against the visceral membrane and the parietal membrane with a chemical adhesive applied to the mesh patch.

8. The method of claim 5, wherein step (c) comprises securing the mesh patch against the visceral membrane and the parietal membrane with a chemical adhesive applied to the mesh patch, and wherein said chemical adhesive is a chemical adhesive selected from the group consisting of:

a fibrin backed adhesive;

a cyanoacrylate bond adhesive; and

an aldehyde bond adhesive.

9. The method of claim 5, wherein step (c) comprises securing the mesh patch against the visceral membrane and the parietal membrane with a chemical adhesive applied to the mesh patch, and wherein said chemical adhesive is a radiopaque chemical adhesive.

10. The method of claim 5, wherein:

step (c) comprises securing the mesh patch against the visceral membrane and the parietal membrane with a chemical adhesive applied to the mesh patch, and wherein said chemical adhesive is a radiopaque chemical adhesive; and

further

(e) identifying the localized region of the fusion formed between the parietal membrane and the visceral membrane by locating the radiopaque adhesive.

11. The method of claim 5, wherein step (c) comprises securing the mesh patch against the visceral membrane and the parietal membrane with a suture by threading the suture into the device and using the suture to pull the visceral membrane against the parietal membrane.

12. The method of claim 5, wherein step (a) comprises receiving a biodegradable mesh patch adapted to induce tissue ingrowth.

13. The method of claim 5, wherein step (a) comprises receiving a mesh patch adapted to induce tissue ingrowth, the mesh patch being made of one of a metallic material, a polymeric material and a ceramic material.

14. The method of claim 5, wherein:

step (a) comprises receiving a mesh patch adapted to induce tissue ingrowth, the mesh patch including at least one radiopaque filament; and

further

(e) identifying the localized region of the fusion formed between the parietal membrane and the visceral membrane by locating the radiopaque filament.

15. A localized pleurodesis method comprising:

(a) receiving a mesh patch adapted to induce tissue ingrowth;

(b) inserting the mesh patch through a chest wall into a pleural cavity defined by a visceral membrane and a parietal membrane;

(c) securing the mesh patch to the visceral membrane at a selected location;

(d) securing the mesh patch and the visceral membrane against the parietal membrane at the selected location; and

(e) holding the mesh patch in apposition with both the parietal membrane and visceral membrane until a localized fusion forms between the parietal membrane and the visceral membrane at the selected location.

16. The method of claim 15, wherein step (d) comprises securing the mesh patch and the visceral membrane against the parietal membrane utilizing a suture.

17. The method of claim 15, wherein step (d) comprises securing the mesh patch and the visceral membrane against the parietal membrane utilizing a chemical adhesive.

18. The method of claim 15, wherein step (d) comprises securing the mesh patch against the visceral membrane and the parietal membrane with a chemical adhesive applied to the mesh patch, and wherein said chemical adhesive is a chemical adhesive selected from the group consisting of:

a fibrin backed adhesive;

a cyanoacrylate bond adhesive; and

an aldehyde bond adhesive.

19. The method of claim 15, wherein step (d) comprises securing the mesh patch and the visceral membrane against the parietal membrane by threading a suture into the device and using the suture to pull the visceral membrane against the parietal membrane.

20. The method of claim 15, wherein:

step (a) comprises receiving a mesh patch adapted to induce tissue ingrowth, the mesh patch including at least one radiopaque filament; and

further

(f) locating the localized fusion formed between the parietal membrane and the visceral membrane by locating the radiopaque filament.

21. The method of claim 15, wherein step (a) comprises receiving a biodegradable mesh patch adapted to induce tissue ingrowth.