Methods of making and using surfactant polymers

• US 8,163,302 B2
• Filed: 04/04/2008
• Issued: 04/24/2012
• Est. Priority Date: 04/29/1998
• Status: Expired due to Fees

• Current Assignee: Nanomimetics, Inc.
• Original Assignee: Nanomimetics, Inc.
• Inventors: Marchant, Roger E., Zhang, Tianhong, Qiu, Yongxing, Ruegsegger, Mark A.
• Primary Examiner(s): Tate, Christopher R.
• Assistant Examiner(s): TELLER, ROY R
• Application Number:
  US12/062,768
• Publication Number:
  US 20080262614A1
• Time in Patent Office: 1,481 Days
• Field of Search: None
• US Class Current: 424/423
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 33/0017 using a surface active agent
• CPC Class Codes: A61L 33/08 Polysaccharides
• CPC Class Codes: A61L 33/128 Other specific proteins or polypeptides not covered by A61L33/122 - A61L33/126
• CPC Class Codes: C08B 37/0021 Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
• CPC Class Codes: C08B 37/0078 Degradation products
• CPC Class Codes: C08F 16/06 Polyvinyl alcohol ; Vinyl alcohol
• CPC Class Codes: C08F 26/02 by a single or double bond to nitrogen
• CPC Class Codes: C08F 8/00 Chemical modification by after-treatment graft polymers, block polymers, crosslinking with unsaturated monomers or with polymers C08F251/00 - C08F299/00; of conjugated diene rubbers C08C
• CPC Class Codes: C08L 101/00 Compositions of unspecified macromolecular compounds

Abstract

Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to the backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. Medical devices coated with the surfactant polymers are also provided. The surfactant polymers may be used to decrease the thrombogenic properties, encapsulation, and bacterial colonization of medical devices.

Claims

1. A medical device including one or more surfaces coated with a surfactant polymer, the surfactant polymer comprising:

a) a polymeric backbone of repeating monomeric units;

b) a plurality of hydrophobic side chains comprising from about 2 to about 18 methylene groups, said plurality of hydrophobic side chains being linked to said polymeric backbone by ester linkages, secondary amine linkages, amide linkages, or combinations thereof; and

c) a plurality of hydrophilic side chains linked to the polymeric backbone by ester linkages, secondary amine linkages, or amide linkages, or combinations thereof;

the hydrophilic side chains selected from the group consisting of;

neutral oligosaccharide side chains having an average molecular weight of less than 7000;

charged oligosaccharide side chains having an average molecular weight of less than 10,000;

an oligopeptide of from about 3 to 30 amino acid residues, said oligopeptide having an amino acid sequence which interacts with protein receptors on the surface of cells; and

combinations thereof.

2. The medical device of claim 1, wherein the medical device is a blood contacting medical device.

3. The medical device of claim 1, wherein the medical device is an implantable medical device.

4. The medical device of claim 3, wherein device is a catheter.

5. The medical device of claim 3, wherein the device is a shunt.

6. The medical device of claim 3, wherein the device is a stimulation lead.

7. The medical device of claim 3, wherein the device is a vascular graft.

8. The medical device of claim 3, wherein device is a patch graft.

9. The medical device of claim 3, wherein the device is a stent.

10. The medical device of claim 9, wherein the stent is a vascular stent.

11. The medical device of claim 1, wherein an oligopeptide amino acid sequence is selected from the group consisting of RGD (SEQ ID NO:

1), RGDS (SEQ ID NO;

     2), RGDSP (SEQ ID NO;

     3), RRAR (SEQ ID NO;

     4), RRRKRR (SEQ ID NO;

     5), PPRRARVT (SEQ ID NO;

     6), and PPREVVPRPRP (SEQ ID NO;

     7).