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Formulations of human growth hormone comprising a non-naturally encoded amino acid

  • US 8,163,695 B2
  • Filed: 10/25/2007
  • Issued: 04/24/2012
  • Est. Priority Date: 12/22/2004
  • Status: Expired due to Fees
First Claim
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1. A pharmaceutical formulation of a human growth hormone (hGH) variant comprising one or more non-naturally encoded amino acids wherein the non-naturally encoded amino acids are substituted at positions selected from the group consisting of 35, 92, 131, 134, 143 and 145 of SEQ ID NO:

  • 2 and the non-naturally encoded amino acids have the structure;

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