Regulators of the hedgehog pathway, compositions and uses related thereto
First Claim
1. A veratrum-type alkaloid, wherein the veratrum-type alkaloid includes a nitrogen-containing ring comprising a tertiary amine having an extraannular substituent on the nitrogen,wherein the extraannular substituent incorporates a substituted alkyl substituted with one or more groups selected from aralkyl, heteroaryl, heteroaralkyl, amido, acylamino, carbamate, urea, ketone, sulfonamide, carbocyclyl, heterocyclyl, polycyclyl, ether, halogen, alkenyl, and alkynyl;
- or a pharmaceutically acceptable salt thereof.
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Abstract
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations.
17 Citations
13 Claims
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1. A veratrum-type alkaloid, wherein the veratrum-type alkaloid includes a nitrogen-containing ring comprising a tertiary amine having an extraannular substituent on the nitrogen,
wherein the extraannular substituent incorporates a substituted alkyl substituted with one or more groups selected from aralkyl, heteroaryl, heteroaralkyl, amido, acylamino, carbamate, urea, ketone, sulfonamide, carbocyclyl, heterocyclyl, polycyclyl, ether, halogen, alkenyl, and alkynyl; or a pharmaceutically acceptable salt thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
Specification