Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase

• US 8,163,765 B2
• Filed: 10/05/2010
• Issued: 04/24/2012
• Est. Priority Date: 01/19/2006
• Status: Active Grant

• Current Assignee: Janssen Pharmaceutica NV (Johnson & Johnson)
• Original Assignee: Janssen Pharmaceutica NV (Johnson & Johnson)
• Inventors: Pilatte, Isabelle Noëlle Constance, Angibaud, Patrick René
• Primary Examiner(s): Saeed, Kamal
• Assistant Examiner(s): Bianchi, Kristin
• Application Number:
  US12/898,564
• Publication Number:
  US 20110118291A1
• Time in Patent Office: 567 Days
• Field of Search: 514/275, 544/331
• US Class Current: 514/275
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07D 401/14 containing three or more hetero rings

Abstract

This invention comprises the novel compounds of formula (1)

wherein R¹, R², R³, R⁴, R⁵, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

Claims

1. A compound of formula (A),

2. A process for preparing a compound as claimed in claim 1, characterized by

a) reacting an intermediate of formula (III-a) with an intermediate of formula (VII) to form a compound of formula (A) in which Q is tetrahydropyranyloxyaminocarbonyl, represented by formula (II):