Systems and methods for measuring pulse wave velocity with an intravascular device

• US 8,165,656 B2
• Filed: 01/13/2010
• Issued: 04/24/2012
• Est. Priority Date: 08/23/2004
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Sathyanarayana, Shashidhar
• Primary Examiner(s): Cheng, Jacqueline
• Application Number:
  US12/686,565
• Publication Number:
  US 20100113949A1
• Time in Patent Office: 832 Days
• Field of Search: 600/438, 600/407, 600/454, 600/459
• US Class Current: 600/407
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/0285 Measuring or recording phase velocity of blood waves
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00

Abstract

The systems and methods described herein allow measurement of the velocity of a pulse wave propagating within a body lumen using an intravascular elongate medical device. The elongate medical device can include a data collection device configured to collect pulse wave data at a location within the lumen. The data collection device is communicatively coupled with a velocity measurement system and configured to output the collected data to the velocity measurement system. The velocity measurement system is configured to calculate the velocity of the pulse wave based on the collection data. The velocity of a pulse wave over a region of the lumen can be used for tissue characterization, diagnosis and the like.

Claims

1. A medical system for calculating a velocity of pulse waves propagating along a patient blood vessel, comprising:

an elongate medical device configured and arranged for insertion into a lumen of the patient blood vessel and positioning at a target velocity-measuring region along the blood vessel, the medical device comprising

a first data collection device disposed on a first elongate section, and

a second data collection device disposed on a second elongate section, wherein the target velocity-measuring region is the portion of the blood vessel between the first and second data collection devices, wherein at least a portion of the second elongate section on which the second data collection device is disposed is extendable from the first elongate section, wherein extending the second elongated section from the first elongate section causes a change in a distance between the first data collection device and the second data collection device, thereby causing a corresponding change in a length of the target velocity-measuring region,

wherein one of the first or second data collection device is configured and arranged to collect first pulse wave data from a first pulse wave propagating along the blood vessel and the other of the first or second data collection device is configured and arranged to collect second pulse wave data from a second pulse wave propagating along the blood vessel; and

a velocity measurement system communicatively coupled to both the first and second data collection devices, wherein the velocity measurement system is configured and arranged to collect both the first pulse wave data and the second pulse wave data, and wherein the velocity measurement system is configured and arranged to calculate the velocity of pulse waves propagating along the target velocity-measuring region based on both the first pulse wave data and the second pulse wave data.

2. The medical system of claim 1, wherein the first pulse wave and the second pulse wave are cardiac pulse waves.

3. The medical system of claim 1, further comprising a reference source coupled to the velocity measurement system, wherein the reference source is configured and arranged to create a first trigger point at a start of collection of the first pulse wave data and a second trigger point at a start of collection of the second pulse wave data.

4. The medical system of claim 3, wherein the reference source is a heart monitor.

5. The medical system of claim 3, wherein the velocity measurement system is configured and arranged to measure the velocity of pulse waves propagating along the target velocity-measuring region based, at least in part, on a difference in time durations between an occurrence of the first trigger point and the collection of the first pulse wave data and an occurrence of the second trigger point and the collection of the second pulse wave data.

6. The medical system of claim 5, wherein the velocity measurement system is configured and arranged to measure the velocity of pulse waves propagating along the target velocity-measuring region based, at least in part, on the first data collection device being a known distance from the second data collection device.

7. The medical system of claim 1, wherein the first pulse wave data and the second pulse wave data comprise image data of a wall of the lumen.

8. The medical system of claim 1, wherein the first data collection device and the second data collection device are ultrasound transducers.

9. The medical system of claim 1, wherein the first data collection device and the second data collection device are optical imagers.

10. The medical system of claim 1, wherein the first pulse wave data and the second pulse wave data comprise pressure data within the lumen of the blood vessel at the target velocity-measuring region.

11. The medical system of claim 1, wherein the first data collection device and the second data collection device are pressure sensors.

12. The medical system of claim 1, wherein the first data collection device and the second data collection device are displacement sensors.

13. The medical system of claim 1, wherein the elongate medical device is configured and arranged to telescope such that at least a portion of one of the first elongate section or the second elongate section is configured and arranged to slide axially into a lumen of the other of the first elongate section or the second elongate section.

14. The medical system of claim 1, wherein the elongate medical device is a catheter.

15. The medical system of claim 1, wherein the elongate medical device is an endoscope.

16. A method of calculating a velocity of pulse waves propagating along a target velocity-measuring region of patient blood vessel, comprising:

inserting an elongate medical device into a lumen of the blood vessel of the patient, the medical device comprising a first data collection device disposed on a first elongate section, and a second data collection device disposed on a second elongate section, wherein the target velocity-measuring region is a portion of the blood vessel between the first and second data collection devices;

collecting first pulse wave data from a first pulse wave propagating along the blood vessel using one of the first or second data collection devices;

collecting second pulse wave data from a second pulse wave propagating along the blood vessel using the other of the first or second data collection devices, wherein the first pulse wave and the second pulse waves are different pulse waves from one another;

transmitting the first pulse wave data and the second pulse wave data to a velocity measurement system; and

calculating, using the velocity measurement system, the velocity of pulse waves propagating along the target velocity-measuring region based on both the first pulse wave data and the second pulse wave data.

17. The method of claim 16, wherein collecting first pulse wave data from the first pulse wave propagating along the blood vessel using one of the first or second data collection devices comprises collecting and averaging data from a plurality of pulse waves.

18. The method of claim 16, wherein collecting second pulse wave data from the second pulse wave propagating along the blood vessel using the other of the first or second data collection devices comprises collecting and averaging data from a plurality of pulse waves.

19. The method of claim 16, further comprising collecting third pulse wave data from a third pulse wave propagating along the blood vessel.

20. The method of claim 16, further comprising extending at least a portion of the second elongate section on which the second data collection device is disposed from the first elongate section to cause a change in a distance between the first data collection device and the second data collection device, thereby causing a corresponding change in the length of the target velocity-measuring region.