Bubble generator having disposable bubble cartridges

• US 8,167,280 B2
• Filed: 03/23/2009
• Issued: 05/01/2012
• Est. Priority Date: 03/23/2009
• Status: Active Grant

• Current Assignee: Ulthera Inc. (Merz Pharma GmbH & Company Kgaa)
• Original Assignee: Cabochon Aesthetics, Inc. (Merz Pharma GmbH & Company Kgaa)
• Inventors: Chomas, James E., Sutton, Doug S.
• Primary Examiner(s): Bushey, Charles
• Application Number:
  US12/409,366
• Publication Number:
  US 20100237163A1
• Time in Patent Office: 1,135 Days
• Field of Search: 261/75, 261/83, 261/100, 261/102, 261/105, 261/96, 239/8
• US Class Current: 261/83
• CPC Class Codes: B01F 2101/2202 Mixing compositions or mixers in the medical or veterinary field
• CPC Class Codes: B01F 25/45 Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads B01F25/44 takes precedence
• CPC Class Codes: B01F 25/4521 the components being pressed through orifices in elements, e.g. flat plates or cylinders, which obstruct the whole diameter of the tube
• CPC Class Codes: B01F 31/55 the materials to be mixed being contained in a flexible bag submitted to periodical deformation
• CPC Class Codes: B01F 35/713 comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartments or cartridges containers or packages per se B65D
• CPC Class Codes: B01F 35/7163 the containers being connected in a mouth-to-mouth, end-to-end disposition, i.e. the openings are juxtaposed before contacting the contents

Abstract

Disclosed is a device and method for generating a microbubble infused solution, the device having a cartridge including a first and second compartment separated by a small channel, wherein the cartridge is formed from a pliable and gas-impermeable material, and having a bubble solution inside the cartridge. Applying pressure to a substantial portion of an outer side of a selected compartment forces at least a portion of the bubble solution inside the selected compartment through the small channel to an unselected compartment and form microbubbles inside the cartridge.

Claims

1. A device for generating a microbubble infused solution, comprising:

a cartridge including a first and second compartment separated by a small channel, wherein the cartridge is formed from a pliable and gas-impermeable material;

a bubble solution disposed inside the cartridge,

wherein applying pressure to a substantial portion of an outer side of a selected compartment will collapse the pliable material and force at least a portion of the bubble solution disposed inside the selected compartment through the small channel to an unselected compartment and form microbubbles inside the cartridge; and

a peel off tab, the peel off tab allowing access to a self-sealing membrane configured to allow perforation by a needle.

2. The cartridge of claim 1, wherein the bubble solution comprises:

an aqueous solution;

a first surfactant;

a second surfactant, different from the first surfactant; and

a gas.

3. The cartridge of claim 1, wherein the bubble solution is hermetically sealed within the cartridge.

4. The cartridge of claim 1, further comprising a nipple with a cap, the nipple allowing access to the bubble solution.

5. The device of claim 1, further comprising:

a bubble cartridge actuator comprising;

a rigid base;

a receptacle for receiving the cartridge; and

a first and a second compression member, wherein each compression member is configured to apply pressure to substantial portion of a respective compartment of the cartridge when the cartridge is received into the receptacle in order to facilitate a formation of microbubbles inside the cartridge.

6. The bubble cartridge actuator of claim 5, further comprising:

a driving mechanism,

wherein the receptacle is positioned adjacent to a center of the base, and

wherein the base is configured to be rotated about the center by the driving mechanism at a high velocity to separate the bubble solution in a compartment furthest from the center by driving an amount of solution comprising bubbles having a mean diameter greater than about 10 microns toward the small channel, at least some of the amount of solution passing through the channel to a compartment closest to the center.

7. The bubble cartridge actuator of claim 6, further comprising:

a traversing frame secured to the base along a side of the receptacle; and

a lever pivotably mounted to the traversing frame,

wherein the lever is mounted to a mounting fixture configured to selectively traverse along the traversing frame, and

wherein a distal end of the lever is configured to divide the bubble solution in a chosen portion of the cartridge by pinching the chosen portion between the distal end of the lever and the base.

8. The bubble cartridge actuator of claim 7, further comprising a second lever.

9. The bubble cartridge actuator of claim 7, wherein the actuator is microprocessor controlled.

10. The cartridge of claim 7, further comprising:

a flexible tube extending from the cartridge and having a swivel fitting near an end of the tubing, the end of the tubing having a connector for sealably connecting the tubing to another tubing,

wherein the base has a hole at the center adaptably configured to receive the swivel fitting such that the tubing is in fluid communication with the cartridge and the actuator is in fluid isolation from the bubble solution.

11. The bubble cartridge actuator of claim 5, further comprising a housing, the housing having a opening adaptably configured to receive a tubing through the opening.

12. A method for generating a microbubble infused solution, comprising:

providing a cartridge including a first and second compartment separated by a small channel, wherein the cartridge is formed from a pliable and gas-impermeable material, and

wherein a bubble solution is disposed inside the cartridge;

applying pressure to a substantial portion of an outer side of a first selected compartment to collapse the pliable material and force at least a portion of the bubble solution disposed inside the first selected compartment through the small channel to a first unselected compartment to form microbubbles inside the cartridge.

13. The method of claim 12, further comprising:

applying pressure to a substantial portion of an outer side of a second selected compartment to collapse the pliable material and force at least a portion of the bubble solution disposed inside the second selected compartment through the small channel to a second unselected compartment to form microbubbles inside the cartridge.

14. The method of claim 13, further comprising:

repeating said steps of applying pressure to a substantial portion of an outer side of said first and second selected compartments.

15. The method of claim 12, further comprising:

spinning the cartridge at a high velocity about an axis positioned at or near an end of the cartridge to separate the bubble solution in a compartment furthest from the axis by driving an amount of the bubble solution comprising bubbles having a mean diameter greater than about 10 microns toward the small channel, at least some of the amount of solution passing through the channel to a compartment closest to the axis.

16. The method of claim 15, further comprising:

pinching the pliable material across a compartment containing separated bubble solution to create an ancillary compartment containing a bubble solution comprising bubbles having a mean diameter less than about 10 microns; and

withdrawing the bubble solution comprising bubbles having a mean diameter less than about 10 microns from the ancillary compartment.

17. The method of claim 16, wherein pinching the pliable material across a compartment containing separated bubble solution includes pinching the pliable material at a first and second position such that the ancillary compartment is formed between an end of the cartridge and the small channel.