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Measurement of tissue elastic modulus

  • US 8,167,804 B2
  • Filed: 10/02/2007
  • Issued: 05/01/2012
  • Est. Priority Date: 10/03/2006
  • Status: Active Grant
First Claim
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1. A method of monitoring vascular wall compliance comprising:

  • measuring pulse wave velocity of the vascular wall over two or more mechanical loads from systolic pressure to equalized pressure;

    measuring intramural strain of the vascular wall over two or more mechanical loads from systolic pressure to equalized pressure; and

    reconstructing an elastic modulus for the vascular wall using the intramural strain and pulse wave velocity;

    wherein the steps of measuring pulse wave velocity and measuring intramural strain each utilize an ultrasound probe and measuring pulse wave velocity comprises estimating the pulse wave velocity from a time delay between two ultrasound beams separated by a known distance.

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