Alkylated interleukin-18 compositions
First Claim
Patent Images
1. A composition comprising (i) an isolated or purified, alkylated IL-18, in which at least one free sulfhydryl of a cysteine residue has been alkylated, and (ii) at least one stabilizing protein.
1 Assignment
0 Petitions
Accused Products
Abstract
Alkylated interleukin-18 (IL-18), compositions comprising alkylated IL-18, kits comprising such compositions, methods of alkylating IL-18, and methods of using compositions comprising alkylated IL-18.
20 Citations
16 Claims
- 1. A composition comprising (i) an isolated or purified, alkylated IL-18, in which at least one free sulfhydryl of a cysteine residue has been alkylated, and (ii) at least one stabilizing protein.
- 9. A series of calibrating compositions, which can be used in a method of determining the concentration of IL-18 in a sample, wherein each of the compositions in the series comprises (i) a known concentration of an isolated or purified, alkylated IL-18, in which at least one free sulfhydryl of a cysteine residue has been alkylated, and (ii) at least one stabilizing protein, wherein each of the compositions differs from the other compositions in the series by the concentration of alkylated IL-18.
-
16. A kit for assaying a test sample for IL-18, which kit comprises at least one component for assaying the test sample for IL-18 and instructions for assaying the test sample for IL-18, wherein the at least one component includes at least one composition comprising (i) a known amount of an isolated or purified, alkylated IL-18, in which at least one free sulfhydryl of a cysteine residue has been alkylated, and (ii) at least one stabilizing protein, wherein, if the kit comprises more than one composition, each of the compositions differs from the other compositions by the concentration of alkylated IL-18.
Specification