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Antisense antiviral compounds and methods for treating a filovirus infection

  • US 8,168,604 B2
  • Filed: 03/11/2009
  • Issued: 05/01/2012
  • Est. Priority Date: 11/01/2004
  • Status: Active Grant
First Claim
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1. A method of treating Marburg virus infection in a subject, the method comprising:

  • administering to a subject a therapeutically effective amount of an antisense oligomer of 12-40 morpholino subunits linked by phosphorous-containing intersubunit linkages which join a morpholino nitrogen of one subunit to a 5′

    exocyclic carbon of an adjacent subunit, wherein at least 2 and no more than half of the total number of intersubunit linkages are positively charged at physiological pH; and

    comprisinga targeting sequence which forms a heteroduplex with a target sequence of the AUG start-site region of a positive-strand mRNA for Marburg viral protein NP;

    wherein the antisense oligomer inhibits virus production.

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