Antibodies specific to heterodimers of Bcl-2 family and uses thereof

• US 8,168,755 B2
• Filed: 05/07/2009
• Issued: 05/01/2012
• Est. Priority Date: 05/07/2008
• Status: Active Grant

• Current Assignee: Eutropics Pharmaceuticals, Inc.
• Original Assignee: Eutropics Pharmaceuticals, Inc.
• Inventors: Cardone, Michael H., Letai, Anthony G.
• Primary Examiner(s): GUSSOW, ANNE
• Application Number:
  US12/437,127
• Publication Number:
  US 20090280510A1
• Time in Patent Office: 1,090 Days
• Field of Search: None
• US Class Current: 530/387.1
• CPC Class Codes: C07K 16/18 against material from animals or humans
• CPC Class Codes: C07K 16/30 from tumour cells
• CPC Class Codes: C07K 2317/622 Single chain antibody (scFv)
• CPC Class Codes: G01N 33/57492 involving compounds localized on the membrane of tumor or cancer cells

Abstract

Isolated antibodies specifically binding to heterodimers of the Bcl-2 family and uses thereof for detecting presence of Bcl-2 heterodimers in a patient.

Claims

1. An isolated antibody that specifically binds to a heterodimer of Bim and Mcl-1.

2. An isolated antibody that specifically binds to a heterodimer of Bim and Bcl-2.

3. An isolated antibody that specifically binds to a heterodimer of Bid and Bcl-2.