Bio-sensor chip for detecting target material

• US 8,169,006 B2
• Filed: 09/16/2009
• Issued: 05/01/2012
• Est. Priority Date: 11/29/2008
• Status: Active Grant

• Current Assignee: Electronics and Telecommunications Research Institute
• Original Assignee: Electronics and Telecommunications Research Institute
• Inventors: Kim, Taeyoub, Yang, Jong-Heon, Ahn, Chang-Geun, Park, Chan Woo, Ah, Chil Seong, Kim, Ansoon, Baek, In Bok, Sung, Gun Yong, Park, Seon Hee
• Primary Examiner(s): Landau, Matthew
• Assistant Examiner(s): BACHNER, ROBERT G
• Application Number:
  US12/561,032
• Publication Number:
  US 20100133510A1
• Time in Patent Office: 958 Days
• Field of Search: 257/253
• US Class Current: 257/253
• CPC Class Codes: B01L 2200/025 Align devices or objects to ensure defined positions relative to each other
• CPC Class Codes: B01L 2300/0645 Electrodes
• CPC Class Codes: B01L 2300/0822 Slides
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: B01L 9/527 for microfluidic devices, e.g. used for lab-on-a-chip
• CPC Class Codes: G01N 27/4145 specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
• CPC Class Codes: G01N 27/4146 involving nanosized elements, e.g. nanotubes, nanowires

Abstract

Provided is a bio-sensor chip. The bio-sensor chip includes a sensing part, a board circuit part, a channel part, and a cover. In the sensing part, a target material and a detection material interact with each other to detect the target material. The board circuit part is electrically connected to the sensing part. The channel part provides a solution material containing the target material into the sensing part. The cover is coupled to the board circuit part to cover the channel part and the sensing part.

Claims

1. A bio-sensor chip comprising:

a sensing part in which a target material and a detection material interact with each other to detect the target material;

a board circuit part electrically connected to the sensing part;

a channel part providing a solution material containing the target material into the sensing part; and

a cover coupled to the board circuit part to cover the channel part and the sensing part,

wherein the cover includes a first space into which at least a portion of the channel part is inserted, and a second space into which the sensing part is inserted, and

wherein the cover applies pressure to the channel part to seal a coupling between the channel part and the sensing part so that the solution material flowing along the channel part is prevented from leaking.

2. The bio-sensor chip of claim 1, wherein the cover comprises a solution inlet providing an input path through which the solution material flows into the channel part and a solution outlet providing an output path through which the solution material flows from the channel part.

3. The bio-sensor chip of claim 2, wherein the cover comprises a transparent body formed of one of polymethylmethacrylate, polycarbonate, cyclic olefine copolymer, polyethylene sulfone, polystyrene, and combinations thereof.

4. The bio-sensor chip of claim 2, wherein the channel part comprises:

a channel inlet vertically aligned with the solution inlet to provide a flow path of the solution material from the solution inlet toward the sensing part;

a channel outlet vertically aligned with the solution outlet to provide a flow path of the solution material from the sensing part toward the solution outlet; and

a fluid channel extending from the channel inlet up to the channel outlet to restrict the flow path of the solution material to the sensing part.

5. The bio-sensor chip of claim 4, wherein the channel part comprises a transparent body formed of polydimethylsiloxane.

6. The bio-sensor chip of claim 4, wherein the sensing part comprises:

a semiconductor substrate; and

a sensor having a detection material disposed on the semiconductor substrate, wherein the sensor contacts the solution material provided through the channel inlet such that the detection material interacts with the target material.

7. The bio-sensor chip of claim 1, wherein the board circuit part comprises:

an upper chip guide comprising a guide groove for guiding a position of the sensing part; and

a lower circuit board electrically connected to the sensing part to input and output an electrical signal of the sensing part.

8. The bio-sensor chip of claim 1, wherein the board circuit part comprises a coupling groove for coupling the cover thereto, and the cover comprises a coupling protrusion inserted into the coupling groove.

9. A bio-sensor chip comprising:

a sensing part comprising a sensor in which a detection material is fixed and a semiconductor substrate on which the sensor is disposed;

a channel part providing a solution material containing a target material interacting with the detection material into the sensing part to contact the solution material with the sensor;

a board circuit part electrically connected to the sensing part to input and output an electrical signal between an external device and the sensing part; and

a cover covering the board circuit part to provide a space in which the sensing part and the channel part are disposed, the cover providing input and output paths of the solution material,

wherein the cover applies pressure to the channel part to seal a coupling between the channel part and the sensing part so that the solution material contacting with the sensor is prevented from leaking.

10. The bio-sensor chip of claim 9, wherein the cover comprises a first transparent cover having a first inlet providing an input path through which the solution material flows into the channel part and a first outlet providing an output path through which the solution material flows from the channel part.

11. The bio-sensor chip of claim 10, wherein the cover further comprises a second transparent cover covering the first transparent cover,

wherein the second transparent cover comprises:

a flow channel providing a flow path of the solution material;

a filter filtering the solution material;

a second inlet providing an input path through which the filtered solution material flows into the first transparent cover and a second outlet providing an output path through which the filtered solution material flows from the first transparent cover; and

a storage container storing the solution material discharged through the second outlet.

12. The bio-sensor chip of claim 9, wherein the sensor comprises:

a plurality of sensor groups independently detecting protein makers different from each other; and

at least one sensor group obtaining a reference signal of an electrical signal change of the sensing part.

13. The bio-sensor chip of claim 9, wherein the board circuit part comprises:

a chip guide comprising a guide groove for guiding a position of the sensing part;

an upper circuit board comprising a substrate bias pad connected to the semiconductor substrate of the sensing part, and a bonding pad connected to the sensing part by a bonding wire; and

a lower circuit board comprising a first layer having a plurality of electrical interconnections connected to the substrate bias pad and the bonding pad, and a second layer having a plurality of connection pads connected to the plurality of electrical interconnections.

14. A bio-sensor chip comprising:

a sensing part comprising a plurality of nano-wire sensors in which a detection material is fixed and a semiconductor substrate on which the plurality of nano-wire sensors are disposed;

a transparent channel part guiding a solution material containing a target material interacting with the detection material such that the solution material flows through the plurality of nano-wire sensors;

a board circuit part electrically connected to the sensing part to input and output an electrical signal between an external device and the sensing part;

a lower transparent cover covering the board circuit part to provide a space in which the sensing part and the channel part are disposed; and

an upper transparent cover covering the lower transparent cover,

wherein the lower transparent cover applies pressure to the channel part to seal a coupling between the channel part and the sensing part so that the solution material flowing through the plurality of nano-wire sensors is prevented from leaking.

15. The bio-sensor chip of claim 14, wherein the lower transparent cover comprises a lower solution inlet providing an input path through which the solution material flows into the transparent channel part and a lower solution outlet providing an output path through which the solution material flows from the transparent channel part.

16. The bio-sensor chip of claim 15, wherein the upper transparent cover comprises:

an upper solution inlet and an upper solution outlet, which are vertically aligned with the lower solution inlet and the lower solution outlet, respectively;

a filter filtering the solution material provided into the upper solution inlet;

a storage container storing the solution material discharged from the upper solution outlet;

a first solution flow channel providing a flow path of the solution material from the filter toward the upper solution inlet; and

a second solution flow channel providing a flow path of the solution material from the upper solution outlet toward the storage container.

17. The bio-sensor chip of claim 16, wherein the transparent channel part comprises:

a channel solution inlet and a channel solution outlet, which are vertically aligned with the lower solution inlet and the lower solution outlet, respectively; and

a fluid channel extending from the channel solution inlet up to the channel solution outlet to allow the solution material to flow on the plurality of nano-wire sensors.

18. The bio-sensor chip of claim 14, wherein the nano-wire sensor comprises:

a silicon nano-channel doped with impurities contacting with the solution material; and

a source/drain disposed at both sides of the silicon nano-channel.

19. The bio-sensor chip of claim 14, wherein the board circuit part comprises:

an upper chip guide comprising a guide groove for guiding a position of the sensing part and a coupling groove for coupling the lower transparent cover thereto; and

a lower printed circuit board comprising an internal connection pad connected to the sensing part, an electrical interconnection electrically connected to the internal connection pad, and an external connection pad connected to the electrical interconnection.

20. The bio-sensor chip of claim 19, wherein the lower transparent cover comprises a coupling protrusion inserted into the coupling groove.