System for electrical modulation of neural conduction
First Claim
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1. A neural modulation system comprising:
- a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure;
a signal processing portion configured to;
distinguish a low activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a higher activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure; and
generate a blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the low activity state; and
a blocking stimulus source configured to produce an electrical field blocking stimulus responsive to the blocking stimulus control signal.
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Abstract
Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with electrical stimuli are disclosed. Methods and systems for reversing effects of blocking stimuli and/or for producing substantially permanent conduction block are also disclosed.
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Citations
38 Claims
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1. A neural modulation system comprising:
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a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure; a signal processing portion configured to; distinguish a low activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a higher activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure; and generate a blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the low activity state; and a blocking stimulus source configured to produce an electrical field blocking stimulus responsive to the blocking stimulus control signal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A neural modulation system comprising:
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a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure; a signal processing portion configured to; distinguish a low activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a higher activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure; and generate a blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the low activity state; and
a blocking stimulus source configured to be worn on the body of the subject and to produce an electrical field blocking stimulus responsive to the blocking stimulus control signal. - View Dependent Claims (20, 21, 22, 23)
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24. A neural modulation system comprising:
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a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure; a signal processing portion configured to; distinguish a low activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a higher activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure; and generate a blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the first low activity state; and a blocking stimulus source configured to be positioned beneath at least a portion of the body of the subject and to produce an electrical field blocking stimulus responsive to the blocking stimulus control signal. - View Dependent Claims (25)
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26. A neural modulation system comprising:
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a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure; a signal processing portion configured to; distinguish a low activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a higher activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure; and generate a blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the low activity state; and a blocking stimulus source configured to be implanted within the body of the subject and to produce an electrical field blocking stimulus responsive to the blocking stimulus control signal.
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27. A neural modulation system comprising:
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a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure; a signal processing portion configured to; distinguish a low activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a higher activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure; generate a blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the low activity state; and
generate a release stimulus control signal for controlling discontinuation of production of the electrical field blocking stimulus when the subject is in the higher activity state; and
a blocking stimulus source configured to produce an electrical field blocking stimulus responsive to the blocking stimulus control signal. - View Dependent Claims (28, 29, 30, 31, 32, 33)
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34. A neural modulation system comprising:
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a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure; a signal processing portion configured to; distinguish a first activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a second activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure; generate a blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the first activity state; and generate a reversing stimulus control signal for driving production of a reversing stimulus to counter the electrical field blocking stimulus used to produce the reversible conduction block in the peripheral neural structure of the subject; a blocking stimulus source configured to produce an electrical field blocking stimulus responsive to the blocking stimulus control signal; and a reversing stimulus source configured to produce a reversing stimulus responsive to the reversing stimulus control signal. - View Dependent Claims (35, 36)
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37. A neural modulation system comprising:
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a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure; a signal processing portion configured to; distinguish a first activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a second activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure; generate a blocking stimulus control signal for driving production of an electrical field blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the first activity state; determine that producing the reversible conduction block in the peripheral neural structure of the subject while the subject is in a first activity state results in a desired effect in the subject; and generate a non-reversible blocking source control signal for driving a non-reversible blocking source to perform an action adapted for producing a non-reversible conduction block in the peripheral neural structure of the subject; a blocking stimulus source configured to produce an electrical field blocking stimulus responsive to the blocking stimulus control signal; and a non-reversible blocking source configured to perform an action adapted for producing a non-reversible conduction block in the peripheral neural structure of the subject responsive to the non-reversible blocking source control signal. - View Dependent Claims (38)
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Specification