Monitoring heart disease using implantable sensors and slopes determined therefrom
First Claim
1. A method for monitoring a patient'"'"'s heart disease, comprising:
- (a) during a period of time, using an implanted sensor to measure a physiologic property when the patient'"'"'s heart is not stressed, and to measure the physiologic property when the patient'"'"'s heart is stressed by pacing the patient'"'"'s heart to exceed a specified threshold for a specified length of time;
(b) determining a slope indicative of a change in the physiologic property that occurs in response to the patient'"'"'s heart changing from not being stressed to being stressed, or vice versa, during the period of time; and
(c) monitoring an extent of the heart disease based on a magnitude of the slope;
wherein the physiologic property is selected from the group consisting of venous oxygen saturation (SVO2), left atrial pressure (LAP), cardiomechanics (CMES), cardiogenic impedance (Zc) and transthoracic impedance (Z).
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Accused Products
Abstract
Specific embodiments of the present invention use an implanted sensor, during a period of time, to measure a physiologic property when the patient'"'"'s heart is not stressed, and when the patient'"'"'s heart is stressed. A slope is determined, where the slope is indicative of a change in the physiologic property during the period of time. Heart disease is monitored based on a magnitude of the slope. In further embodiments of the present invention, a slope indicative of a change in a physiologic property during a period of time is determined, for each of a plurality of periods of time. Changes in the patient'"'"'s heart disease are monitored based on changes in the slope.
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Citations
24 Claims
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1. A method for monitoring a patient'"'"'s heart disease, comprising:
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(a) during a period of time, using an implanted sensor to measure a physiologic property when the patient'"'"'s heart is not stressed, and to measure the physiologic property when the patient'"'"'s heart is stressed by pacing the patient'"'"'s heart to exceed a specified threshold for a specified length of time; (b) determining a slope indicative of a change in the physiologic property that occurs in response to the patient'"'"'s heart changing from not being stressed to being stressed, or vice versa, during the period of time; and (c) monitoring an extent of the heart disease based on a magnitude of the slope; wherein the physiologic property is selected from the group consisting of venous oxygen saturation (SVO2), left atrial pressure (LAP), cardiomechanics (CMES), cardiogenic impedance (Zc) and transthoracic impedance (Z). - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A system for monitoring a patient'"'"'s heart disease, comprising:
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an implantable sensor to measure a physiologic property when the patient'"'"'s heart is not stressed, and to measure the physiologic property when the patient'"'"'s heart is stressed by pacing the patient'"'"'s heart to exceed a specified threshold for a specified length of time; and a heart disease monitor to determine a slope indicative of a change in the physiologic property that occurs in response to the patient'"'"'s heart changing from not being stressed to being stressed, or vice versa, during the period of time; and wherein the monitor monitors the heart disease based on a magnitude of the slope; wherein the physiologic property is selected from the group consisting of venous oxygen saturation (SVO2), left atrial pressure (LAP), cardiomechanics (CMES), cardiogenic impedance (Zc) and transthoracic impedance (Z). - View Dependent Claims (9, 10, 11, 12, 13)
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14. A method for monitoring a patient'"'"'s heart disease, comprising:
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(a) during a period of time, using an implanted sensor to measure a physiologic property when the patient'"'"'s heart is not stressed, and to measure the physiologic property when the patient'"'"'s heart is stressed by pacing the patient'"'"'s heart to exceed a specified threshold for a specified length of time, to thereby determine a slope indicative of a change in the physiologic property that occurs in response to the patient'"'"'s heart changing from not being stressed to being stressed, or vice versa, during the period of time; and (b) repeating step (a) during one or more further period of time, to thereby determine a slope indicative of a change in the physiologic property during each of the one or more further period of time; and (c) monitoring changes in the patient'"'"'s heart disease based on how the slope changes over time; wherein the physiologic property is selected from the group consisting of venous oxygen saturation (SVO2), left atrial pressure (LAP), cardiomechanics (CMES), cardiogenic impedance (Zc) and transthoracic impedance (Z). - View Dependent Claims (15, 16, 17, 18, 19)
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20. A system for monitoring a patient'"'"'s heart disease, comprising:
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at least one pulse generator to generate pacing pulses for pacing the patient'"'"'s heart; an implanted sensor to measure of physiologic property; and a heart disease monitor to monitor the physiologic property when the patient'"'"'s heart is not stressed, and to monitor the physiologic property when the patient'"'"'s heart is stressed by pacing the patient'"'"'s heart to exceed a specified threshold for a specified length of time, to thereby determine a slope indicative of a change in the physiologic property that occurs in response to the patient'"'"'s heart changing from not being stressed to being stressed, or vice versa, for each of a plurality of periods of time; wherein the monitor monitors changes in the patient'"'"'s heart disease based on how a magnitude of the slope changes over time; wherein the physiologic property is selected from the group consisting of venous oxygen saturation (SVO2), left atrial pressure (LAP), cardiomechanics (CMES), cardiogenic impedance (Zc) and transthoracic impedance (Z). - View Dependent Claims (21, 22, 23, 24)
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Specification