Baroreflex sensitivity monitoring and trending for tachyarrhythmia detection and therapy

• US 8,170,668 B2
• Filed: 07/14/2006
• Issued: 05/01/2012
• Est. Priority Date: 07/14/2006
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Ettori, Benjamin, Li, Dan, Libbus, Imad
• Primary Examiner(s): Bertram, Eric D.
• Application Number:
  US11/457,644
• Publication Number:
  US 20080015651A1
• Time in Patent Office: 2,118 Days
• Field of Search: 607/14
• US Class Current: 607/14
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61B 5/7285 for synchronising or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal A61B6/5205, A61B6/541, A61B8/5207, A61B8/543 take precedence
• CPC Class Codes: A61N 1/3621 for treating or preventing abnormally high heart rate

Abstract

A system comprising an implantable medical device (IMD) that includes a tachyarrhythmia detector, a baroreflex detector to obtain baroreflex information, and a processor in communication with the tachyarrhythmia detector and the baroreflex detector. The processor adjusts at least one of a tachyarrhythmia detection parameter of the IMD or a tachyarrhythmia therapy parameter of the IMD using the baroreflex information.

Claims

1. A system comprising:

an implantable medical device (IMD), the IMD including;

a detector configured to detect tachyarrhythmia;

a baroreflex detector to obtain baroreflex information associated with tachyarrhythmia, wherein the baroreflex detector includes a baroreflex sensitivity (BRS) indicator module configured to establish an indicator of the sensitivity of baroreflex of a subject using the baroreflex information, wherein the baroreflex information includes at least one of;

a measure of blood pressure measured synchronously with an artificially induced at least one of cardiac or respiratory perturbation, a measure of heart rate turbulence (HRT), and a measure of heart rate variability (HRV); and

a processor in communication with the tachyarrhythmia detector and the baroreflex detector, the processor configured to adjust at least one of a tachyarrhythmia detection parameter of the IMD or a tachyarrhythmia therapy parameter of the IMD using the BRS indicator.

2. The system of claim 1, wherein the BRS indicator module is configured to establish the BRS indicator using the measure of heart rate turbulence (HRT) measured in association with one or more premature ventricular contractions (PVCs), and wherein the processor is configured to adjust the tachyarrhythmia detection parameter of the IMD or the tachyarrhythmia therapy parameter of the IMD using the BRS indicator.

3. The system of claim 2, wherein the BRS indicator module is configured to establish a BRS indicator using a measure of HRT slope.

4. The system of claim 2, wherein the BRS indicator module is configured to establish a BRS indicator using a measure of HRT onset.

5. The system of claim 2, wherein the BRS indicator module is configured to establish a BRS indicator by applying at least one rule to at least one measure of HRT slope and at least one measure of HRT onset.

6. The system of claim 2, wherein the IMD includes a pacing circuit, in communication with the baroreflex detector, to induce a ventricular contraction in a subject, and wherein the BRS indicator module is configured to recurrently induce one or more PVCs in order to establish the BRS indicator.

7. The system of claim 6, wherein the IMD includes a electrical cardiac signal sensing circuit in communication with the baroreflex detector, wherein the baroreflex detector is configured to detect one or more PVCs and to induce one or more PVCs in the absence of spontaneous PVCs in order to establish the BRS indicator.

8. The system of claim 1, wherein the system includes an implantable blood pressure sensor in communication with the baroreflex detector;

wherein the IMD includes the processor, the baroreflex detector and a pacing circuit coupled to the baroreflex detector, the pacing circuit to induce a ventricular contraction; and

wherein the BRS indicator module is configured to establish the BRS indicator using a measure of blood pressure measured synchronously with ventricular contractions, the ventricular contractions including at least one contraction induced by the IMD.

9. The system of claim 1, wherein the system includes a blood pressure sensor in communication with the baroreflex detector;

wherein the IMD includes a pacing circuit, in communication with the baroreflex detector, to induce a ventricular contraction; and

wherein the BRS indicator module is configured to establish the BRS indicator using a measure of blood pressure measured synchronously with ventricular contractions, the ventricular contractions including at least one contraction induced by the IMD, and wherein the blood pressure sensor, the processor and the baroreflex detector are included in one or more external devices.

10. The system of claim 1, wherein the BRS indicator module is configured to establish the BRS indicator using the measure of heart rate variability (HRV), and wherein the processor is configured to adjust the tachyarrhythmia detection parameter of the IMD or the tachyarrhythmia therapy parameter of the IMD using the BRS indicator.

11. The system of claim 10, wherein the BRS indicator module is configured to establish a BRS indicator using a measure of short-time symbolic HRV.

12. The system of claim 10, wherein the IMD includes a cardiac signal sensing circuit, to sense a cardiac signal representative of successive beat-to-beat intervals, coupled to the tachyarrhythmia detector, and wherein the BRS indicator module is configured to establish a BRS indicator using a measure of HRV that includes a ratio of signal power in a low frequency band to signal power in a high frequency band (LF/HF).

13. The system of claim 10, wherein the IMD includes a cardiac signal sensing circuit, to sense a cardiac signal representative of successive beat-to-beat intervals, coupled to the tachyarrhythmia detector, and wherein the BRS indicator module is configured to establish a BRS indicator using a measure of HRV that includes trending at least one of a standard deviation of normal-to-normal interval (SDNN) index and a standard deviation of averaged normal-to-normal interval (SDANN) index.

14. The system of claim 1, wherein the tachyarrhythmia detection parameter includes one or more parameters selected from the group consisting of:

a number of X fast beats out of Y consecutive beats of the subject to declare an episode of tachyarrhythmia, wherein X and Y are positive integers and X<

Y;

a number of X beats correlated to Y consecutive beats of the subject to declare an episode of supra-ventricular tachycardia (SVT), wherein X and Y are positive integers and X<

Y;

a morphology correlation threshold score used to declare ventricular tachyarrhythmia, wherein a morphology correlation score indicates how well a measured sinus rhythm correlates to a normal sinus rhythm; and

a timed duration for an abnormal rhythm has to persist before an episode of tachyarrhythmia is declared.

15. The system of claim 1, wherein the tachyarrhythmia therapy parameter includes one or more parameters selected from the group consisting of:

an amount of energy to deliver in a shock therapy;

a duration of anti-tachy pacing (ATP) before initiating shock therapy using the baroreflex information; and

a time interval between a last intrinsic beat of the patient before anti-tachy pacing pulses are applied.

16. The system of claim 15, wherein the processor is configured to adjust the tachyarrhythmia therapy parameter using at least one rule applied to the baroreflex information and a heart rate.

17. The system of claim 1, including an external device, wherein the IMD includes the processor, the baroreflex detector, and a communication circuit coupled to the processor, and wherein the IMD is configured to communicate the baroreflex information wirelessly to the external device.

18. The system of claim 1, including an external device that includes a remote server in communication with the IMD over a communications or computer network, wherein the processor and the baroreflex detector are included in the server.

19. A method comprising:

detecting a tachyarrhythmia episode using an implantable medical device (IMD) configured to detect tachyarrhythmia;

obtaining baroreflex information associated with tachyarrhythmia, wherein the baroreflex information includes at least one of;

a measure of blood pressure measured synchronously with an artificially induced at least one of cardiac or respiratory perturbation, a measure of heart rate turbulence (HRT), and a measure of heart rate variability (HRV);

quantizing sensitivity of baroreflex of a subject using the baroreflex information; and

adjusting, by the IMD or a second separate device, at least one of a tachyarrhythmia detection parameter of the IMD or a tachyarrhythmia therapy parameter of the IMD according to the sensitivity of baroreflex.

20. The method of claim 19, further including:

recurrently monitoring baroreflex information;

trending a measure of the baroreflex information; and

wherein quantizing the sensitivity of baroreflex includes quantizing the sensitivity of baroreflex using the trended measure of the baroreflex information.

21. The method of claim 20, further including trending the measure of the baroreflex information after adjusting the tachyarrhythmia therapy parameter of the IMD.

22. The method of claim 20, including:

classifying the tachyarrhythmia episode as ventricular tachycardia (VT) or supra-ventricular tachycardia (SVT);

selecting and delivering a tachyarrhythmia therapy using the quantized baroreflex information if the tachyarrhythmia episode is classified as VT; and

selecting and delivering a tachyarrhythmia therapy if the tachyarrhythmia episode is classified as SVT and if the quantized baroreflex information is abnormally low relative to the trended measure of the baroreflex information.

23. The method of claim 19, wherein quantizing sensitivity of baroreflex includes obtaining an indicator of baroreflex sensitivity (BRS) using a measure of heart rate turbulence (HRT), and wherein the HRT is measured using premature ventricular contractions (PVCs).

24. The method of claim 23, wherein obtaining the BRS indicator includes using a measure of HRT slope.

25. The method of claim 23, wherein obtaining the BRS indicator includes using a measure of HRT onset.

26. The method of claim 23, wherein obtaining the BRS indicator includes applying at least one rule to at least one measure of HRT slope and at least one measure of HRT onset.

27. The method of claim 19, wherein quantizing sensitivity of baroreflex includes obtaining an indicator of baroreflex sensitivity (BRS) indicator using a measure of blood pressure measured synchronously with ventricular contractions, the ventricular contractions including at least one contraction induced by the IMD.

28. The method of claim 19, wherein quantizing sensitivity of baroreflex includes obtaining an indicator of baroreflex sensitivity (BRS) indicator using the measure of heart rate variability (HRV) of the subject.

29. The method of claim 28, wherein the measure of HRV includes using a measure of short-time symbolic HRV of the subject.

30. The method of claim 28, including sensing an electrical cardiac signal representative of successive beat-to-beat intervals, and wherein the measure of HRV includes a ratio of signal power in a low frequency band to signal power in a high frequency band (LF/HF).

31. The method of claim 28, including sensing an electrical cardiac signal representative of successive beat-to-beat intervals, and wherein the measure of HRV includes at least one of a standard deviation of normal-to-normal interval (SDNN) index and a standard deviation of averaged normal-to-normal interval (SDANN) index.