Conduit system for isolation of fluids in biological tissues

• US 8,172,783 B1
• Filed: 12/30/1999
• Issued: 05/08/2012
• Est. Priority Date: 12/30/1999
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Ray, Pinaki
• Primary Examiner(s): BOUCHELLE, LAURA A
• Application Number:
  US09/475,768
• Time in Patent Office: 4,513 Days
• Field of Search: 604/4.01, 604 501- 504, 604 601- 616, 604 8- 9, 604506-509, 604/93.01, 604/96.01, 604 9701- 9703, 604 9801- 9802, 604 9901- 9903, 604/103.3, 604/173, 604/264, 604/523, 604/532, 604/284, 604/103.01
• US Class Current: 604/4.01
• CPC Class Codes: A61B 17/1204 temporary occlusion
• CPC Class Codes: A61B 17/12122 within the heart for closing a cardiac septal defect A61B17/0057
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61M 2025/0031 characterized by lumina for withdrawing or delivering, i.e. used for extracorporeal circuit treatment
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 25/0032 characterized by at least one unconventionally shaped lumen, e.g. polygons, ellipsoids, wedges or shapes comprising concave and convex parts
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00

Abstract

The invention presents is a fluid isolation system and method for confining fluid is a biological mass having at least one upstream channel and downstream channel. The system includes a delivery conduit for administering fluid to the biological mass and a collection conduit having and external seal and for retrieving the fluid. In the use of the system, the delivery conduit is positioned adjacent to or into the upstream channel and the collection conduit is inserted adjacent to or into the downstream channel. In one manner to confine the fluid, the seal on the collection catheter is activated to occlude outside fluid flow and divert the fluid into the lumen of the catheter.

Claims

1. A system for fluid isolation in a biological mass having at least one upstream channel and at least one downstream channel, comprising:

a delivery conduit for administering a fluid to the biological mass, the delivery conduit having a length dimension suitable to be positioned from a first externally accessible channel of a patient adjacent to or into at least one upstream channel of the biological mass by way of a percutaneous transluminal route; and

a collection conduit for acquiring the administered fluid, the collection conduit having a length dimension suitable to be positioned from a second externally accessible channel of a patient adjacent to or into at least one downstream channel of the biological mass by way of a percutaneous transluminal route and having a collection seal having a dimension, in one configuration, to occlude the at least one downstream channel;

wherein the biological mass is selected from the group consisting of a heart, a portion of a heart, a kidney, a portion of a kidney, a stomach, a liver, and a brain.

2. The system of claim 1, further including a driving force in communication with the delivery conduit for encouraging fluid through the delivery conduit.

3. The system of claim 1, wherein the delivery conduit is for administering fluid during at least a substantial period of diastole.

4. The system of claim 1, wherein the delivery conduit is for administering fluid during the period of diastole and the period of systole.

5. The system of claim 1 wherein the delivery conduit further includes a delivery seal having a dimension, in one configuration, to occlude the at least one upstream channel and the delivery conduit defines a delivery opening distal to the delivery seal.

6. The system of claim 5 wherein the delivery seal is an elastomeric balloon.

7. The system of claim 6, wherein, in another configuration, the delivery seat allows fluid flow past the delivery seal.

8. The system of claim 7, further including a seal control mechanism for contracting and expanding the delivery seal.

9. The system of claim 8, wherein the seal control mechanism is configured to expand the delivery seal during at least a substantial period of diastole and contract the delivery seal during at least a substantial period of systole.

10. The system of claim 1, wherein the biological mass is a human heart.

11. The system of claim 1, wherein the delivery conduit is such that the delivery conduit may be positioned into an aorta of a patient and the length dimension of the collection conduit is such that the collection conduit may be positioned into a coronary sinus of the patient.

12. The system of claim 1, wherein the fluid includes an agent.

13. The system of claim 12, wherein the agent is selected from the group consisting of natural and synthetic drugs, growth factors, gene therapy compositions, chemotherapeutic chemicals, anti-bacterial chemicals, anti-angiogenic chemicals and any combination thereof.

14. The system of claim 1, wherein the first externally accessible channel is selected from one of a femoral artery and a radial artery.

15. The system of claim 14, wherein the second externally accessible channel is a jugular vein.

16. A system comprising:

a delivery conduit having a length dimension suitable to be positioned by a percutaneous transluminal route from a first externally accessible channel of a patient adjacent to or into an upstream channel of a biological mass selected from the group consisting of a heart, a portion of a heart, a kidney, a portion of a kidney, a stomach, a liver, and a brain, and where the biological mass comprises at least one upstream channel and at least one downstream channel;

a separate collection conduit having a dimension suitable to be positioned by a percutaneous transluminal route from a second externally accessible channel of a patient adjacent to or into a downstream channel of the biological mass, the separate collection conduit comprising a collection seal for occluding fluid flow by the collection seal; and

a fluid to be administered to the biological mass through the delivery conduit, and reclaimed by the collection conduit, wherein the system achieves fluid isolation in the biological mass between the upstream channel and the downstream channel has at least one upstream channel and at least one downstream channel.

17. The system of claim 16, wherein the fluid further comprises an agent.

18. The system of claim 17, wherein the agent is selected from the group consisting of natural and synthetic drugs, growth factors, gene therapy compositions, chemotherapeutic chemicals, anti-bacterial chemicals, anti-angiogenic chemicals, and combinations thereof.

19. The system of claim 16, wherein the delivery conduit further comprises a delivery seal for occluding external fluid flow.

20. The system of claim 19, wherein the delivery seal comprises an elastomeric balloon.

21. The system of claim 16, further comprising a pressure device, wherein the pressure device is in fluid communication with the delivery conduit.

22. The system of claim 21, wherein the pressure device exerts a positive pressure, and the pressure device is selected from the group consisting of positive displacement pumps, syringes, vacuum pumps, delivery pumps, suction pumps, metering pumps, and intra-aortic balloon pumps.

23. The system of claim 16, further comprising a pressure device in fluid communication with the collection conduit.

24. The system of claim 23, wherein the pressure device exerts a negative pressure, and the pressure device is selected from the group consisting of positive displacement pumps, syringes, vacuum pumps, delivery pumps, suction pumps, metering pumps, and intra-aortic balloon pumps.

25. The system of claim 16, wherein the delivery conduit comprises a delivery catheter, wherein the delivery catheter includes three internal lumens.

26. The system of claim 16, wherein the delivery conduit comprises a delivery catheter, wherein the delivery catheter comprises as separate lumens, a balloon inflation lumen, a guidewire lumen, and a drug delivery lumen.

27. The system of claim 16, wherein the separate collection conduit comprises a collection catheter, wherein the collection catheter comprises three lumens.

28. The system of claim 16, wherein the separate collection conduit comprises a collection catheter, wherein the collection catheter comprises as separate lumens, a drainage lumen, a guidewire lumen, and a balloon inflation lumen.

29. The system of claim 16, wherein the first externally accessible channel is selected from one of a femoral artery and a radial artery.

30. The system of claim 29, wherein the second externally accessible channel is a jugular vein.