Methods and apparatus for atrioventricular valve repair

• US 8,172,856 B2
• Filed: 07/28/2003
• Issued: 05/08/2012
• Est. Priority Date: 08/02/2002
• Status: Active Grant

• Current Assignee: Cedars-Sinai Medical Center (Cedars Sinai Health System)
• Original Assignee: Cedars-Sinai Medical Center (Cedars Sinai Health System)
• Inventors: Eigler, Neal L., Price, Matthew J., Siegel, Robert J.
• Primary Examiner(s): McDermott, Corrine M
• Assistant Examiner(s): RYCKMAN, MELISSA K
• Application Number:
  US10/628,880
• Publication Number:
  US 20040059351A1
• Time in Patent Office: 3,207 Days
• Field of Search: 623/2.36, 606/139, 606/144, 606/148, 606/232
• US Class Current: 606/139
• CPC Class Codes: A61B 17/0469 Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
• CPC Class Codes: A61B 17/0491 Sewing machines for surgery
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61B 2017/00292 mounted on or guided by flexible, e.g. catheter-like, means
• CPC Class Codes: A61B 2017/003 Steerable
• CPC Class Codes: A61B 2017/00783 Valvuloplasty
• CPC Class Codes: A61B 2017/0472 Multiple-needled, e.g. double-needled, instruments
• CPC Class Codes: A61B 2017/0608 J-shaped
• CPC Class Codes: A61B 2017/22038 with a guide wire
• CPC Class Codes: A61B 2017/22069 Immobilising; Stabilising

Abstract

Methods and devices are disclosed for minimally invasive procedures in the heart. In one application, a catheter is advanced from the left atrium through the mitral valve and along the left ventricular outflow tract to orient and stabilize the catheter and enable a procedure such as a “bow tie” repair of the mitral valve. Right heart procedures are also disclosed.

Claims

1. A catheter, comprising:

an elongate flexible body, having a proximal end and a distal end, the elongate flexible body having housed therein a fastening material configured to suture two heart leaflets together;

an anchor zone on a distal portion of the flexible body;

a first tissue manipulator and a second tissue manipulator carried by the catheter proximally of the anchor zone, the tissue manipulators being capable of being moved independently of each other and having a fixed end and a free end, the free ends being moveable to an extended position in which the free ends are proximal of the fixed ends, the tissue manipulators being disposed in the extended position such that an angle of not more than 90 degrees is defined between a portion of the elongate flexible body disposed proximally of the fixed ends and an adjacent portion of each of the tissue manipulators facing the portion of the elongate flexible body disposed proximally of the fixed ends;

a first receptacle located within the first tissue manipulator for receiving a first fixating member;

a second receptacle located within the second tissue manipulator for receiving a second fixating member; and

a first end of a fastening material disposed within the first receptacle and a second end of the fastening material is disposed within the second receptacle;

wherein a portion of the elongate flexible body located proximal of the tissue manipulators is sufficiently flexible and has sufficient length to enable the tissue manipulators to be advanced from a peripheral venous or arterial blood vessel to a left atrium of a heart, and through a mitral valve of the heart;

wherein the distal portion is configured to extend at least into an anatomical region adjoining the heart valve and the anchor zone is configured to orient and anchor the catheter so that the tissue manipulators can be positioned at the valve.

2. A catheter as in claim 1, wherein the minimum length of the anchor zone on the distal side of the tissue manipulator is at least about 3 cm.

3. A catheter as in claim 1, wherein the minimum length of the anchor zone on the distal side of the tissue manipulator is at least about 5 cm.

4. A catheter as in claim 1, wherein the minimum length of the anchor zone on the distal side of the tissue manipulator is at least about 10 cm.

5. A catheter as in claim 1, wherein the tissue manipulator is moveable between an axial orientation for transluminal navigation and an inclined orientation for manipulating tissue.

6. A catheter as in claim 1, wherein the first tissue manipulator comprises a tissue grasper for grasping a heart valve leaflet.

7. A catheter as in claim 1, comprising at least a first component which is axially moveable with respect to a second component.

8. The catheter as in claim 1, wherein the distal portion is configured to extend from a left atrium, through a mitral valve and into a left ventricular outflow tract.

9. The catheter as in claim 1, wherein the distal portion is configured to extend through a left ventricular outflow tract into an aorta.

10. The catheter as in claim 1, wherein the distal portion is configured to extend through a tricuspid valve and into a right ventricular outflow tract.

11. The catheter as in claim 1, wherein the distal portion is configured to extend through a right ventricular outflow tract into a pulmonary artery.

12. The catheter as in claim 1, wherein the first tissue manipulator is asymmetric to the second tissue manipulator.

13. The catheter as in claim 12, wherein the first tissue manipulator is longer than the second tissue manipulator.

14. A catheter as in claim 1, wherein the tissue manipulator comprises a first elongate tissue manipulator having a first length and a second tissue manipulator having a second length, the first and second tissue manipulators both configured to engage portions of a heart valve from the same side of the valve, the second length being greater than the first length.

15. A catheter as in claim 1, wherein the first and second tissue manipulators are capable of sequential deployment.

16. A catheter as in claim 1, wherein the shape of the catheter acts as a fulcrum about which the catheter can be manipulated with respect to the individual valve leaflets.

17. A catheter system as in claim 1, wherein at least one of the first and second tissue manipulators is configured to self-deploy to the extended position from a retracted position, wherein the retracted position is suitable for transluminal advancement.

18. A catheter system as in claim 17, wherein at least one of the first and second tissue manipulators is coupled with a hinge comprising stored energy when the tissue manipulator coupled therewith is in the retracted position.

19. A catheter system as in claim 17, wherein the catheter system comprises a structure for restraining the tissue manipulators in the retracted position during transluminal advancement.

20. A catheter system as in claim 19, wherein the catheter system comprises an actuator for providing relative movement between the restraining structure and the elongate body, wherein in a first position the restraining structure maintains the tissue manipulators in the retracted position and a second position the restraining structure permits at least one of the tissue manipulators to self-deploy.

21. A catheter system as in claim 20, wherein the actuator provides for relative movement to a third position in which the restraining structure permits the first and the second tissue manipulators to self-deploy.