Compositions and methods for joining non-conjoined lumens
First Claim
Patent Images
1. A thermoreversible sol-gel composition for surgical use having a phase transition temperature from a liquid phase to a gel phase of at least 1°
- C. above or below the temperature of the surgical field and a gel phase elastic modulus of at least 8,000 Pascals, which composition comprisesa) about 25 to 33% of a mixture of poloxamer 407 and poloxamer 188 in a ratio of between 3;
1 and 0.8;
1; and
b) an aqueous salt solution having an ionic strength of from about 0.05 M to about 0.4 M.
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Abstract
Sol-gel compositions, methods, and kits for joining together non-conjoined lumens in a patient'"'"'s body including vascular lumens. More particularly, in various aspects, this invention provides thermoreversible sol-gel compositions, methods, and kits for joining such non-conjoined lumens, including small lumens typically requiring microsurgical technique.
101 Citations
38 Claims
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1. A thermoreversible sol-gel composition for surgical use having a phase transition temperature from a liquid phase to a gel phase of at least 1°
- C. above or below the temperature of the surgical field and a gel phase elastic modulus of at least 8,000 Pascals, which composition comprises
a) about 25 to 33% of a mixture of poloxamer 407 and poloxamer 188 in a ratio of between 3;
1 and 0.8;
1; andb) an aqueous salt solution having an ionic strength of from about 0.05 M to about 0.4 M. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
- C. above or below the temperature of the surgical field and a gel phase elastic modulus of at least 8,000 Pascals, which composition comprises
Specification