Embolization

• US 8,173,176 B2
• Filed: 03/30/2004
• Issued: 05/08/2012
• Est. Priority Date: 03/30/2004
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Kamath, Kalpana, Freyman, Toby, Mishra, Shubhang
• Primary Examiner(s): Lorengo, Jerry
• Assistant Examiner(s): Parvini, Pegah
• Application Number:
  US10/814,079
• Publication Number:
  US 20050226935A1
• Time in Patent Office: 2,961 Days
• Field of Search: 424/489, 424/488, 424/402, 424/78.37, 424/78.18, 424/9.52, 424/1.49, 424/724, 252/62.53, 264/5, 514/57, 514/2, 514/54, 106/409, 502/407
• US Class Current: 424/724
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12186 liquid materials adapted to be injected
• CPC Class Codes: A61K 49/0002 General or multifunctional contrast agents, e.g. chelated agents
• CPC Class Codes: A61L 24/001 Use of materials characterised by their function or physical properties
• CPC Class Codes: A61L 24/0089 containing inorganic fillers not covered by groups A61L24/0078 or A61L24/0084
• CPC Class Codes: A61L 2430/36 for embolization or occlusion, e.g. vaso-occlusive compositions or devices artificial blood vessels A61L27/507
• CPC Class Codes: A61L 31/128 containing other specific inorganic fillers not covered by A61L31/126 or A61L31/127
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/18 Materials at least partially X-ray or laser opaque
• CPC Class Codes: C01B 33/124 Preparation of adsorbing porous silica not in gel form and not finely divided, i.e. silicon skeletons, by acidic treatment of siliceous materials

Abstract

Embolization, as well as related particles, compositions and methods, are disclosed.

Claims

1. A composition, comprising:

a plurality of substantially spherical porous silica particles, at least some of the plurality of substantially spherical silica particles having a diameter of from about 100 microns to about 3000 microns; and

a carrier fluid, the plurality of substantially spherical porous particles being in the carrier fluid,

wherein;

for at least some of the plurality of substantially spherical porous silica particles, a pore volume of the substantially spherical porous silica particles is from about 0.4 ml/g to about 1.6 ml/g; and

the plurality of substantially spherical porous silica particles have a pore volume distribution such that about 70% or more of the pore volume of the plurality of substantially spherical porous silica particles is made up of pores having pore diameters which have a tolerance of about 10 nm or less on the mean pore diameter.

2. The composition of claim 1, wherein the carrier fluid comprises a saline solution.

3. The composition of claim 1, wherein the carrier fluid comprises a contrast agent.

4. The composition of claim 1, wherein at least some of the plurality of substantially spherical porous silica particles have a diameter of at most about 1500 microns.

5. The composition of claim 1, wherein, for at least some of the plurality of substantially spherical porous silica particles, pores in the substantially spherical porous silica particles have a diameter of from about 20 nanometers to about 90 nanometers.

6. The composition of claim 1, wherein, for at least some of the plurality of substantially spherical porous silica particles, the density of the particles is from about 1.1 grams per cubic centimeter to about 1.4 grams per cubic centimeter.

7. The composition of claim 1, wherein the substantially spherical porous silica particles exhibit a loss of attrition resistance of about 0.1% by weight or less.

8. The composition of claim 1, wherein at least some of the plurality of substantially spherical porous silica particles include a material selected from the group consisting of therapeutic agents, ferromagnetic materials, MRI visible materials and radiopaque materials.

9. The composition of claim 1, wherein the plurality of substantially spherical porous silica particles are sterilized.

10. A composition, comprising:

a plurality of substantially spherical porous silica particles, at least some of the plurality of substantially spherical silica particles having a diameter of from about 100 microns to about 3000 microns; and

a carrier fluid, the plurality of substantially spherical porous particles being in the carrier fluid,

wherein, for at least some of the plurality of substantially spherical porous silica particles, the density of the particles is from about 1.1 grams per cubic centimeter to about 1.4 grams per cubic centimeter, and the carrier fluid comprises a saline solution, wherein the plurality of substantially spherical porous silica particles have a pore volume distribution such that about 70% or more of the pore volume of the plurality of substantially spherical porous silica particles is made up of pores having pore diameters which have a tolerance of about 10 nm or less on the mean pore diameter.

11. The composition of claim 10, wherein the substantially spherical porous silica particles exhibit a loss of attrition resistance of about 0.1% by weight or less.

12. A composition, comprising:

a plurality of substantially spherical porous silica particles, at least some of the plurality of substantially spherical silica particles having a diameter of from about 100 microns to about 3000 microns; and

a carrier fluid, the plurality of substantially spherical porous particles being in the carrier fluid,

wherein the plurality of substantially spherical porous silica particles have a pore volume distribution such that about 70% or more of the pore volume of the plurality of substantially spherical porous silica particles is made up of pores having pore diameters which have a tolerance of about 10 nm or less on the mean pore diameter.

13. The composition of claim 12, wherein the substantially spherical porous silica particles exhibit a loss of attrition resistance of about 0.1% by weight or less.