Polymer cement for percutaneous vertebroplasty

• US 8,173,721 B2
• Filed: 06/21/2004
• Issued: 05/08/2012
• Est. Priority Date: 05/14/2004
• Status: Expired due to Fees

• Current Assignee: Teknimed SA
• Original Assignee: Teknimed SA
• Inventors: Lavergne, Claudine, Leonard, Alain
• Primary Examiner(s): Yoon, Tae H
• Application Number:
  US10/871,036
• Publication Number:
  US 20050256220A1
• Time in Patent Office: 2,878 Days
• Field of Search: 523/117, 523/116
• US Class Current: 523/117
• CPC Class Codes: A61L 24/0094 containing macromolecular fillers
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/446 with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
• CPC Class Codes: C08L 33/12 Homopolymers or copolymers of methyl methacrylate

Abstract

A fluid cement for medical use for bone reconstruction, in particular for filling the vertebral body, and a binary composition which is intended for the preparation of such a cement. A device for conditioning the binary composition, and a method of preparing a bone cement from a binary composition. The fluid cement according to the invention comprises: a) approximately 70% to 85% by weight of a polymer comprising a polymethylmethacrylate and a methylmethacrylate monomer, and b) approximately from 15 to 30% by weight of a radio-opaque composition. Preferably, the radio-opaque composition comprises a radio-opacifier, such as a barium sulphate and zirconium dioxide, in a mixture with a calcium phosphate, for example hydroxyapatite.

Claims

1. A binary composition comprising a liquid component L and a powder component P,

wherein the liquid component comprises a methylmethacrylate monomer, a polymerization activator, and stabilizer;

wherein the powder component comprises a polymethylmethacrylate homopolymer, a polymerization initiator and at least 35% of a radio-opaque composition, wherein the radio-opaque composition comprises 30-45% of a radio-opaque compound and 5-10% calcium phosphate, and

wherein the powder component P and the liquid component L are provided in a weight ratio P/L between 1.4 and 1.5.

2. A binary composition according to claim 1, wherein said radio-opaque compound is barium sulphate or zirconium dioxide.

3. A binary composition according to claim 1, wherein the calcium phosphate is hydroxyapatite.

4. A device intended for preparation of a fluid cement for medical use from a binary composition according to claim 1, comprising:

i) a first receptacle containing the liquid component L, and

ii) a second receptacle containing the powder component P.

5. A method of preparing a fluid cement, for medical use, for filling the vertebral body, comprising essentially the step consisting in mixing the components made of powder P and liquid L according to claim 1 into a homogeneous mass in a weight ratio P/L between 1.4 and 1.5.

6. A binary composition according to claim 1, wherein the chemical polymerisation activator is dimethylparatoluidine.

7. A binary composition according to claim 1, wherein the polymerisation initiator is benzoyl peroxide and the stabiliser is hydroquinone.

8. A fluid cement, for medical use, for filling the vertebral body, comprising:

a) approximately 80% by weight of a polymer comprising a polymethylmethacrylate homopolymer, methylmethacrylate monomer, a polymerization activator, initiator, and stabilizer; and

b) approximately 20% by weight of a radio-opaque composition, wherein the radio-opaque composition comprises a radio-opaque compound and hydroxyapatite, wherein the radio-opaque compound makes up approximately 14% by weight of the fluid cement, and wherein the calcium phosphate makes up approximately 6% by weight of the fluid cement.

9. A fluid cement, for medical use, for filling the vertebral body, comprising:

a) approximately 76% by weight of a polymer comprising a polymethyimethacrylate homopolymer, methylmethacrylate monomer, a polymerization activator, initiator, and stabilizer; and

b) approximately 24% by weight of a radio-opaque composition, wherein the radio-opaque composition comprises a radio-opaque compound and hydroxyapatite, wherein the radio-opaque compound makes up approximately 18% by weight of the fluid cement, and wherein the calcium phosphate makes up approximately 6% by weight of the fluid cement.

10. A fluid cement, for medical use, for filling the vertebral body, comprising:

a) approximately 70% by weight of a polymer comprising a polymethylmethacrylate homopolymer, methylmethacrylate monomer, a polymerization activator, initiator, and stabilizer; and

b) approximately 30% by weight of a radio-opaque composition, wherein the radio-opaque composition comprises a radio-opaque compound and hydroxyapatite, wherein the radio-opaque compound makes up approximately 24% by weight of the fluid cement, and wherein the hydroxyapatite makes up approximately 6% by weight of the fluid cement.

11. A fluid cement, for medical use, for filling the vertebral body, comprising:

a) approximately 70% by weight of a polymer comprising a polymethylmethaerylate homopolymer, methylmethacrylate monomer, a polymerization activator, initiator, and stabilizer; and

b) approximately 30% by weight of a radio-opaque composition, wherein the radio-opaque composition comprises a radio-opaque compound and hydroxyapatite, wherein the radio-opaque compound makes up approximately 27% by weight of the fluid cement, and wherein the hydroxyapatite makes up approximately 3% by weight of the fluid cement.