Speckle reduction in optical coherence tomography by path length encoded angular compounding

• US 8,174,702 B2
• Filed: 07/27/2009
• Issued: 05/08/2012
• Est. Priority Date: 01/24/2003
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Tearney, Guillermo J., Iftimia, Nicusor, Bouma, Brett E.
• Primary Examiner(s): Lyons, Michael A
• Application Number:
  US12/510,047
• Publication Number:
  US 20100157309A1
• Time in Patent Office: 1,016 Days
• Field of Search: 356/479, 356/497
• US Class Current: 356/479
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: G01B 9/02028 Two or more reference or object arms in one interferometer
• CPC Class Codes: G01B 9/02082 Caused by speckles
• CPC Class Codes: G01B 9/02087 Combining two or more images of the same region
• CPC Class Codes: G01B 9/02091 Tomographic interferometers, e.g. based on optical coherence
• CPC Class Codes: G01J 9/0215 by shearing interferometric methods
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B
• CPC Class Codes: G02B 26/105 with one or more pivoting mirrors or galvano-mirrors G02B26/101 takes precedence
• CPC Class Codes: G02B 27/48 Laser speckle optics

Abstract

Speckle, a factor reducing image quality in optical coherence tomography (“OCT”), can limit the ability to identify cellular structures that are important for the diagnosis of a variety of diseases. Exemplary embodiments of the present invention can facilitate an implementation of an angular compounding, angular compounding by path length encoding (“ACPE”) for reducing speckle in OCT images. By averaging images obtained at different incident angles, with each image encoded by path length, ACPE maintains high-speed image acquisition and implements minimal modifications to OCT probe optics. ACPE images obtained from tissue phantoms and human skin in vivo demonstrate a qualitative improvement over traditional OCT and an increased signal-to-noise ratio (“SNR”). Accordingly, exemplary embodiments of an apparatus probe catheter and method can be provided for irradiating a structure. In particular, an interferometer may forward forwarding an electromagnetic radiation. In addition, a sample arm may receive the electromagnetic radiation, and can include an arrangement which facilitates a production of at least two radiations from the electromagnetic radiation so as to irradiate the structure. Such exemplary arrangement can be configured to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations.

Claims

1. An apparatus for irradiating a structure, comprising:

a sample arm configuration configured to receive an electromagnetic radiation and including an arrangement, the arrangement being configured to produce at least two radiations from the electromagnetic radiation so as to irradiate the structure and delay a first radiation of the radiations with respect to a second radiation of the radiations, wherein the arrangement including at least one of;

a first optical section with a refractive index of at least 1.5, the first section being structured to propagate the radiations, and

a second section which has silicon, the second section being structured to propagate the radiations.

2. The apparatus according to claim 1, wherein the refractive index of the optical section is at least 3.0.

3. The apparatus according to claim 1, wherein at least one of the first section or the second section comprises an anti-reflection-coated BK 7 glass.

4. The apparatus according to claim 3, wherein the glass has a thickness of from about 1.6 mm to about 7.7 mm.

5. The apparatus according to claim 1, wherein at least one of the first section or the second section comprises an anti-reflection-coated glass that has a refractive index of from about 1.51 to about 3.5.

6. An apparatus for obtaining information associated with a structure, comprising;

a first arrangement configured to received first and second radiations from the structure associated with particular radiations forwarded to the structure which have different path lengths and a third radiation received from a reference, and generate at least one interference signal as a function of the first, second and third radiations;

a second arrangement configured to generate;

first data associated with the first radiation which includes a first speckle pattern and second data associated with the second radiation which includes a second speckle pattern, and

third data associated with the structure based on the first and second data that has a speckle pattern the amount of which is smaller that the amount of at least one of the first speckle pattern or the second speckle pattern.

7. The apparatus according to claim 6, further comprising a further arrangement configured to forward the particular radiations to the structure, wherein the further arrangement includes an optical section with a refractive index of at least 1.5, the optical section being structured to propagate the first and second radiations.

8. The apparatus according to claim 6, further comprising a further arrangement configured to forward the particular radiations to the structure, wherein the further arrangement includes a section which has silicon that is structured to propagate the first and second radiations.

9. The apparatus according to claim 6, further comprising a further arrangement configured to forward the particular radiations to the structure, wherein the further arrangement includes a section which has an anti-reflective coating on at least one surface thereof, the section being structured to propagate the first and second radiations.

10. The apparatus according to claim 6, wherein the second arrangement is further configured to generate third data corresponding to an amount of a ranging depth within the structure associated with the first arrangement, wherein a difference between the path lengths of the first and second radiations is equal or greater than the ranging depth, and wherein the ranging depth is a penetration depth in the structure which includes an anatomical structure.

11. The apparatus according to claim 6, wherein the first, second and the third data are images, the third image data having a noise that is smaller than a noise of the first image data and a noise of the second image data.

12. The apparatus according claim 6, wherein the first, second and the third data are images, and wherein the third arrangement is configured to generate the third image data based on a mathematical combination of the first and second image data.

13. The apparatus according to claim 6, further comprising an additional arrangement which is configured to irradiate the structure by a first irradiation of the particular radiations at a first angle, and by a second radiation of the particular radiations at a second angle, the first and second angles being different from one another.

14. The apparatus according to claim 13, wherein the first and second angle are different from one another as a function of a delay between the first and second radiations and at least one of a phase or a incident angle of each of the first and second radiations.

15. The apparatus according to claim 6, further comprising a detection arrangement which is configured to detect the first radiation, and forwards the detected energy to the second arrangement.

16. The apparatus according to claim 6, further comprising a third arrangement which includes two sections, each section being configured to delay a respective one of the first and second radiations, and wherein a delay of the first radiation is greater than a delay of the second radiation.

17. The apparatus according to claim 6, further comprising a further arrangement configured to receive a plurality of radiation and irradiate the structure and delay at least one radiation of the radiations with respect to at least another one radiation of the radiations, wherein the arrangement including at least one of:

a first optical section with a refractive index of at least 1.5, the first section being structured to propagate the radiations, and

a second section which has silicon, the second section being structured to propagate the radiations.

18. The apparatus according to claim 17, wherein the refractive index of the optical section is at least 3.0.

19. The apparatus according to claim 17, wherein at least one of the first section or the second section comprises an anti-reflection-coated BK 7 glass.

20. The apparatus according to claim 19, wherein the glass has a thickness of from about 1.6 mm to about 7.7 mm.

21. The apparatus according to claim 17, wherein at least one of the first section or the second section comprises an anti-reflection-coated glass that has a refractive index of from about 1.51 to about 3.5.

22. An apparatus for obtaining information associated with a structure, comprising;

a first arrangement configured to separate at least one first electro-magnetic radiation into a first radiation and a second radiation forwarded to the structure, wherein the first and second radiations have different path lengths;

a second arrangement configured to received third and fourth radiations from the structure associated with the first and second radiations and a fifth radiation received from a reference; and

a third arrangement configured to generate data corresponding to an amount of a ranging depth within the structure associated with the second arrangement, wherein a difference between the path lengths of the first and second radiations is equal or greater than the ranging depth.