Method and apparatus for spectroscopic tissue analyte measurement
First Claim
1. A method for calculating one or more body fluid metrics, comprising:
- acquiring an absorbance spectrum of a subject'"'"'s tissue at a range of wavelengths of light;
determining concentrations of a plurality of constituents of the subject'"'"'s tissue by performing a multi-linear regression of the absorbance spectrum in relation to a plurality of absorbance spectra of the constituents; and
calculating one or more body fluid metrics based on the concentrations.
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Abstract
Methods and systems for calculating body fluid metrics are provided. In accordance with an exemplary embodiment of the present technique, there is provided a method for calculating body fluid metrics by acquiring an absorbance spectrum of a subject'"'"'s tissue over a range of near-infrared light, performing a multi-linear regression of the absorbance spectrum of the subject'"'"'s tissue in relation to absorbance spectra of tissue constituents, and calculating body fluid metrics based on the results of the multi-linear regression. A system is provided having a sensor for emitting the light into the subject'"'"'s tissue and detecting reflected, scattered, or transmitted light, a spectrometer for processing the detected light and generating the absorbance spectrum of the subject'"'"'s tissue, memory for storing absorbance spectra of the tissue constituents and a multi-linear regression model, and a processor for performing the multi-linear regression and calculating the body fluid metrics.
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Citations
51 Claims
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1. A method for calculating one or more body fluid metrics, comprising:
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acquiring an absorbance spectrum of a subject'"'"'s tissue at a range of wavelengths of light; determining concentrations of a plurality of constituents of the subject'"'"'s tissue by performing a multi-linear regression of the absorbance spectrum in relation to a plurality of absorbance spectra of the constituents; and calculating one or more body fluid metrics based on the concentrations. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method for calculating one or more body fluid metrics, comprising:
- measuring an intensity spectrum of a subject'"'"'s tissue;
processing the intensity spectrum to determine an absorbance spectrum of the tissue;
performing a multi-linear regression of the absorbance spectrum in relation to a plurality of analyte absorbance spectra, wherein the analytes are representative of tissue constituents;
determining concentrations of the tissue constituents based on the multi-linear regression; and
calculating one or more body fluid metrics based on the concentrations. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
- measuring an intensity spectrum of a subject'"'"'s tissue;
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30. A system for calculating one or more body fluid metrics, comprising:
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a sensor configured to emit a range of wavelengths of light into a subject'"'"'s tissue and to detect reflected, scattered, or transmitted light; a spectrometer configured to process the reflected, scattered, or transmitted light and to generate an absorbance spectrum of the subject'"'"'s tissue across the range of wavelengths of light; a memory configured to store a plurality of absorbance spectra of tissue constituents across the range of wavelengths of light and to store a multi-linear regression model; and a processor configured to perform a multi-linear regression of the absorbance spectrum of the subject'"'"'s tissue with respect to the plurality of absorbance spectra of tissue constituents based on the multi-linear regression model and to calculate one or more body fluid metrics based on the multi-linear regression. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37)
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38. One or more tangible, non-transitory machine-readable media, comprising code executable to perform the acts of:
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performing a multi-linear regression of an absorbance spectrum of a subject'"'"'s tissue in relation to a plurality of absorbance spectra of skin constituents; and calculating one or more body fluid metrics based on the multi-linear regression. - View Dependent Claims (39, 40, 41, 42, 43)
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44. A monitor for calculating one or more body fluid metrics, comprising:
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a spectrometer configured to process light acquired from detection of reflected, scattered, or transmitted light emitted at a range of wavelengths into a subject'"'"'s tissue and to generate an absorbance spectrum of the subject'"'"'s tissue across the range of wavelengths of light; a memory configured to store a plurality of absorbance spectra of tissue constituents across the range of wavelengths of light and to store a multi-linear regression model; and a processor configured to perform a multi-linear regression of the absorbance spectrum of the subject'"'"'s tissue with respect to the plurality of absorbance spectra of tissue constituents based on the multi-linear regression model and to calculate one or more body fluid metrics based on the multi-linear regression. - View Dependent Claims (45, 46, 47, 48, 49, 50, 51)
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Specification