Optical device for assessing optical depth in a sample

• US 8,175,690 B2
• Filed: 02/18/2008
• Issued: 05/08/2012
• Est. Priority Date: 02/20/2007
• Status: Expired due to Fees

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Hendriks, Bernardus H. W., Zou, Hans, Van Gogh, Antonius T. M.
• Primary Examiner(s): Le, Long V.
• Assistant Examiner(s): Negarestan, Farshad
• Application Number:
  US12/527,727
• Publication Number:
  US 20100113941A1
• Time in Patent Office: 1,541 Days
• Field of Search: None
• US Class Current: 600/478
• CPC Class Codes: A61B 2562/0242 for varying or adjusting the optical path length in the tissue
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/444 Evaluating skin marks, e.g. mole, nevi, tumour, scar
• CPC Class Codes: G01N 2021/4792 Polarisation of scatter light
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

An optical device for assessing optical depth in a sample illuminated by polarized radiation from a source include two radiation guides having their end portions arranged for capturing reflected radiation from the sample. A detector measures two polarizations of the reflected radiation, and two intensities of the reflected radiation in the two radiation guides, respectively. A processor is configured to calculate two pectral functions, which are indicative of single scattering events in the sample. The processor is further configured to calculate a measure of the correlation between the two spectral functions so as to assess whether the single scattering events originate from substantially the same optical depth within the sample. Thus, the causal relation between the two spectral functions can be used for assessing whether the single scattering events giving rise to the two spectral functions come from substantially the same optical depth within the sample.

Claims

1. An optical device for assessing optical depth in an associated sample, the device comprising:

a radiation source capable of emitting radiation with an initial polarization;

a first radiation guide and a second radiation guide, the first radiation guide being optically connected to the radiation source for emitting radiation to the sample, the first radiation guide and the second radiation guide having their respective end portions substantially aligned with each other, the end portions further being arranged for capturing reflected radiation from the sample;

a detector being optically connected to the first radiation guide and the second radiation guide, the detector being arranged for measuring, within an optical subband, an indication of;

a first polarization of the reflected radiation,

a second polarization of the reflected radiation, said second polarization being different from the first polarization, and

a first intensity and a second intensity of the reflected radiation in the first radiation guide and the second radiation guide, respectively; and

a processor operably connected to the detector, the processor being adapted to calculate a first spectral function and a second spectral function within the optical subband, the first spectral function and the second spectral function being substantially indicative of single scattering events in the sample, the first spectral function being a measure of the a difference in polarization between the first polarization of the reflected radiation and the second polarization of the reflected radiation, and the second spectral function being a measure of the a difference in intensity between the first intensity and the second intensity of the reflected radiation,

wherein the processor is further arranged to calculate a measure of a correlation between the first spectral function and the second spectral function so as to assess whether the single scattering events originate from substantially the same optical depth within the sample.

2. The optical device according to claim 1, wherein the first spectral function is a polarized light scattering spectroscopy function.

3. The optical device according to claim 1, wherein the second spectral function is a measure of the differential path length between the first radiation guide and the second radiation guide.

4. The optical device according to claim 1, wherein the detector is arranged for measuring, within the optical subband, the first polarization and the second polarization of the reflected radiation captured by the first radiation guide.

5. The optical device according to claim 1, further comprising a third radiation guide is arranged for transmitting radiation with the initial polarization to the sample, the third radiation guide having an end portion substantially aligned with the end portions of the first radiation guide and the second radiation guide.

6. The optical device according to claim 5, wherein the third radiation guide is arranged for capturing the reflected radiation from the sample, the third radiation guide being optically connected to the detector.

7. The optical device according to claim 5, wherein at least one of the first radiation guide, the second radiation guide and the third radiation guide are optical fibers having a diameter of maximum 200 micrometer.

8. The optical device according to claim 5, wherein at least one of the first radiation guide, the second radiation guide, and the third radiation guide forms part of a catheter.

9. The optical device according to claim 5, wherein at least one of the first radiation guide, the second radiation guide and the third radiation guide are optical fibers having a diameter of maximum 50 micrometer.

10. The optical device according to claim 1, wherein the detector is arranged for measuring the first polarization and the second polarization of the reflected radiation in two substantially orthogonal directions.

11. The optical device according to claim 1, wherein the radiation source is arranged for emitting radiation having the initial polarization linearly polarized in a plane substantially parallel to a polarization plane of the measured first polarization or the measured second polarization.

12. The optical device according to claim 1, wherein the processor is further arranged for determining the correlation for more than one region within the optical subband, the processor being adapted to subsequently select a region of optimum correlation for subsequent optical measurements.

13. The optical device according to claim 1, wherein the processor is further arranged for changing the optical subband in dependency on the calculated correlation.

14. The optical device according to claim 1, further comprising an actuator arranged for changing at least a distance of the respective end portions between the first radiation guide and the second radiation guide in dependency of the correlation.

15. A catheter configured for cooperation with an associated optical device, the catheter comprising:

a first and a second radiation guide, the first radiation guide being optically connectable to a radiation source for emitting radiation to a sample, the first radiation guide and the second radiation guide having their respective end portions substantially aligned with each other, the end portions further being arranged for capturing reflected radiation from the sample,

the associated optical device comprising;

a radiation source capable of emitting radiation with an initial polarization;

a detector being optically connected to the first and the second radiation guides, the detector being arranged for measuring, within an optical subband, an indication of;

a first polarization of the reflected radiation,

a second polarization of the reflected radiation, said second polarization being different from the first polarization, and

a first intensity and a second intensity of the reflected radiation in the first radiation guide and the second radiation guide, respectively; and

a processor operably connected to the detector, the processor being configured to calculate a first spectral function and a second spectral function within the optical subband, the first spectral function and the second spectral function being substantially indicative of single scattering events in the sample, the first spectral function being a measure of the a difference in polarization between the first polarization of the reflected radiation and the second polarization of the reflected radiation, and the second spectral function being a measure of the a difference in intensity between the first intensity and the second intensity of the reflected radiation,

the processor further being arranged to calculate a measure of a correlation between the first spectral function and the second spectral function so as to assess whether the single scattering events originate from substantially a same optical depth within the sample.

16. The catheter according to claim 15, further comprising a third radiation guide is arranged for transmitting radiation with the initial polarization to the sample, the third radiation guide having an end portion substantially aligned with the end portions of the first radiation guide and the second radiation guide.

17. The catheter according to claim 16, wherein the third radiation guide is arranged for capturing the reflected radiation from the sample, the third radiation guide being optically connectable to the detector.

18. The catheter according to claim 16, wherein at least one of the first radiation guide, the second radiation guide and the third radiation guide have polarization conserving properties.

19. A method for operating an optical device for assessing optical depth in a sample, the method comprising the acts of:

emitting radiation with an initial polarization with a radiation source;

arranging a first radiation guide and a second radiation guide in relation to the sample, the first radiation guide being optically connected to the radiation source for emitting radiation to the sample, the first radiation guide and the second radiation guide having their respective end portions substantially aligned with each other, the end portions further being configured for capturing reflected radiation from the sample;

measuring by a detector in optical connection to the first and the second radiation guides, within an optical subband, an indication of;

a first polarization of the reflected radiation,

a second polarization of the reflected radiation, said second polarization being different from the first polarization, and

a first intensity and a second intensity of the reflected radiation in the first radiation guide and the second radiation guide, respectively; and

calculating by a processor operably connected to the detector, a first spectral function and a second spectral function within the optical subband, the first spectral function and the second spectral function being substantially indicative of single scattering events in the sample, the first spectral function being a measure of the a difference in polarization between the first polarization of the reflected radiation and the second polarization of the reflected radiation, and the second spectral function being a measure of the a difference in intensity between the first intensity and the second intensity of the reflected radiation; and

calculating by the processor a measure of a correlation between the first spectral function and the second spectral function so as to assess whether the single scattering events originate from substantially the same optical depth within the sample.

20. A non-transitory computer readable medium embodying computer instructions which, when executed by a processor, configure the processor to perform the method of claim 19.