T-wave alternans train spotter

• US 8,175,695 B2
• Filed: 02/18/2010
• Issued: 05/08/2012
• Est. Priority Date: 01/13/2003
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Rouw, Mattias, Van Groeningen, Christianus J. J. E., De Bruyn, Henricus Willem M.
• Primary Examiner(s): Heller, Tammie K
• Application Number:
  US12/708,080
• Publication Number:
  US 20100145404A1
• Time in Patent Office: 810 Days
• Field of Search: 600/509, 600/516
• US Class Current: 600/516
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions

Abstract

A method and system for detecting T-wave alternans for use in an implanted medical device uses wave transformation of QT intervals to obtain a reliable measure of TWA. In one embodiment, an array provides alternating sign multiplication factors which are applied respectively to n consecutive QT values. Each successive QT value is high pass filtered and moved sequentially through a queue so that each cycle each of the n QT values is multiplied by one of the factors; the products are summed and made absolute to provide an alternans match value. The alternans match is compared with a noise threshold signal, and alternans is declared when the match exceeds the threshold by a predetermined amount. The array is programmable and can be varied, providing a high degree of flexibility to optimize the test for the patient.

Claims

1. A method of determining an indication of T-wave alternans using an implantable medical device, comprising:

using said device to detect time values of T-wave signals;

storing said detected time values in a queue within said device;

operating on n of said stored time values using a transform program within said device including pattern factors in the form of alternating positive and negative factors by multiplying said stored time values by said positive and negative pattern factors to produce a value indicative of a degree of T-wave alternans;

detecting the occurrence of T-wave alternans responsive to said indicative value exceeding a defined threshold value;

storing a record of said occurrence of T-wave alternans within said device, and

transmitting said record to an external device.

2. The method of claim 1, wherein the queue comprises a queue of the n most recent of said stored time values.

3. The method of claim 2, wherein said transform program comprises n alternating sign multipliers.

4. The method of claim 3, wherein operating on n of said stored time values comprises obtaining a summation of the products of multiplying said stored time values by said alternating sign multipliers.

5. The method of claim 4, further comprising converting said summation to an absolute value.

6. The method of claim 5, wherein detecting the occurrence of T-wave alternans comprises defining a noise threshold value and comparing said noise threshold value and said summation absolute value.

7. The method of claim 6, further comprising high pass filtering of said stored time values.

8. The method of claim 7, comprising using said transform array program to provide said high pass filtering of said stored time values.