System and method for testing neural stimulation threshold
First Claim
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1. A method for implanting a neural stimulator, comprising:
- implanting a neural stimulation lead;
delivering neural stimulation through the neural stimulation lead to an autonomic neural target; and
verifying neural stimulation capture of the autonomic neural target, wherein verifying capture includes measuring heart rate turbulence (HRT) and using the measured HRT to determine if the neural stimulation is capturing the autonomic neural target.
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Abstract
Various system embodiments comprise a neural stimulator, a premature ventricular contraction (PVC) event detector, a heart rate detector, an analyzer, and a controller. The neural stimulator is adapted to generate a stimulation signal adapted to stimulate an autonomic neural target. The analyzer is adapted to, in response to a PVC event signal from the PVC event detector, generate an autonomic balance indicator (ABI) as a function of pre-PVC heart rate data and post-PVC heart rate data. Other aspects and embodiments are provided herein.
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Citations
23 Claims
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1. A method for implanting a neural stimulator, comprising:
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implanting a neural stimulation lead; delivering neural stimulation through the neural stimulation lead to an autonomic neural target; and verifying neural stimulation capture of the autonomic neural target, wherein verifying capture includes measuring heart rate turbulence (HRT) and using the measured HRT to determine if the neural stimulation is capturing the autonomic neural target. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A neural stimulation system for setting a stimulation level for stimulating an autonomic nervous system (ANS), the system comprising:
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a neural stimulator configured to stimulate an autonomic neural target in the ANS; a heart rate detector configured to detect heart rate; an analyzer connected to the heart rate detector and configured to measure heart rate turbulence (HRT) using detected heart rate before a premature ventricular contraction (PVC) and detected heart rate after the PVC; and a controller configured to receive HRT measurements from the analyzer and provide an indication whether a stimulation level provides threshold stimulation. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A neural stimulation system to modulate autonomic balance in an autonomic nervous system (ANS), the system comprising:
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a neural stimulator configured to stimulate an autonomic neural target to modulate the autonomic balance in the ANS; a premature ventricular contraction (PVC) stimulator configured to induce a PVC using a myocardial pacing pulse; a heart rate detector configured to detect heart rate; an analyzer connected to the heart rate detector and configured to measure heart rate turbulence (HRT) for the induced PVC using the detected heart rate; and a controller configured to; control the neural stimulator to generate a neural stimulation signal to stimulate the autonomic neural target; control the PVC stimulator to induce the PVC; and use the measured HRT to determine whether the neural stimulation signal evokes a response above a threshold.
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23. A method for modulating autonomic balance in an autonomic nervous system (ANS), the method comprising:
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stimulating an autonomic neural target to modulate the autonomic balance in the ANS; and performing a neural stimulation threshold test, wherein performing the neural stimulation threshold test includes; inducing a premature ventricular contraction (PVC) event or detecting an intrinsic PVC event; detecting heart rate; measuring heart rate turbulence (HRT) in response to the PVC event using the detected heart rate; and determining whether the neural stimulation signal evokes a threshold response based on the measured HRT.
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Specification