Cardiac resynchronization therapy parameter optimization

• US 8,175,703 B2
• Filed: 01/25/2006
• Issued: 05/08/2012
• Est. Priority Date: 01/25/2006
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Dong, Yanting, Yu, Yinghong, Ding, Jiang, Meyer, Scott A., Wei, Xuan, Stucky, Michael John
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): KIMBALL, JEREMIAH T
• Application Number:
  US11/338,935
• Publication Number:
  US 20100023078A1
• Time in Patent Office: 2,295 Days
• Field of Search: 607/9
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber

Abstract

Systems and methods involve determination of CRT parameters using a number of CRT optimization processes. Each CRT optimization process attempts to return recommended parameters. The CRT parameters are determined based on the recommended parameters returned by one or more of the CRT optimization processes. The CRT optimization processes may be sequentially implemented and the CRT parameters may be determined based on the recommended parameters returned by a first CRT optimization process to return recommended parameters. The CRT parameters may be determined based on a combination of the recommended parameters returned. The CRT optimization processes implemented may be selected from available CRT optimization processes based on patient conditions.

Claims

1. A method for operating a cardiac device to algorithmically determine a value of a parameter for use in delivery of cardiac resynchronization therapy (CRT), the method comprising:

implementing a first cardiac resynchronization therapy (CRT) optimization process by analyzing a first set of physiological signals and returning a first recommended value for a CRT parameter based on the first set of physiological signals;

adjusting a CRT parameter value search range of at least one additional CRT optimization process based on the first recommended value, the first CRT optimization process based on a different process of optimization with respect to the at least one additional CRT optimization process;

implementing the at least one additional CRT optimization process by analyzing a second set of physiological signals and using the adjusted value search range to return an additional recommended value for the CRT parameter for each additional CRT optimization process; and

determining the value of the CRT parameter for use in delivery of CRT by the cardiac device based on the additional recommended values returned by the one or more additional CRT optimization processes.

2. The method of claim 1, wherein implementing the at least one additional CRT optimization process comprises sequentially implementing a plurality of additional CRT optimization processes that are different from the first CRT optimization process.

3. The method of claim 2, wherein sequentially implementing the plurality of additional CRT optimization processes comprises sequentially implementing the plurality of additional CRT optimization processes according to a predetermined order indicated by a physician.

4. The method of claim 1, wherein determining the value of the CRT parameter comprises combining recommended values returned by two or more different CRT optimization processes of the first CRT optimization process and the at least one additional CRT optimization process.

5. The method of claim 1, wherein implementing the at least one additional CRT optimization process comprises:

implementing a plurality of additional CRT optimization processes, including implementing a first group of the plurality of CRT optimization processes and implementing a second group of the plurality of additional CRT optimization processes if the recommended values returned by the first group produce an ambiguity in selection of the value of the CRT parameter, wherein each CRT optimization process of the first group is different from each CRT optimization process of the second group.

6. The method of claim 1, wherein implementing the at least one additional CRT optimization process comprises selectively implementing the at least one additional CRT optimization process based on patient condition information acquired from at least one of an implantable or patient-external device.

7. The method of claim 1, wherein the first CRT optimization process is different from the at least one additional CRT optimization process in that the processes are based on different types of physiological signals.

8. The method of claim 1, wherein the first CRT optimization process is different from each of the at least one additional CRT optimization process in that one process is morphology based and the other process is timing based.

9. The method of claim 1, wherein the CRT parameter comprises at least one of a pacing energy, a pacing waveform, a pacing site, a pacing mode, a pacing rate, an atrioventricular delay, an interventricular delay, and an interatrial delay.

10. The method of claim 1, further comprising implementing CRT using the determined value of the CRT parameter.

11. A medical system, comprising:

sensor circuitry configured to sense physiological signals;

a first cardiac resynchronization therapy (CRT) optimization module configured to implement a first CRT value optimization process, the first CRT optimization module configured to analyze one or more of the sensed physiological signals and to return a first recommended value for a CRT delivery parameter as part of implementation of the first CRT value optimization process;

one or more additional CRT optimization modules configured to implement one or more additional CRT value optimization processes, each additional CRT optimization module configured to analyze one or more of the sensed physiological signals and to use a CRT parameter value search range adjusted using the first recommended value to return an additional recommended value for the CRT delivery parameter as part of implementation of a respective one of the one or more additional CRT value optimization processes, the first CRT value optimization process based on a different process of optimization with respect to the one or more additional CRT optimization processes; and

a processor configured to determine a value of the CRT delivery parameter for use in implementing CRT based on the additional recommended values returned by the one or more additional CRT optimization modules.

12. The medical system of claim 11, wherein the first CRT optimization module is configured to analyze a first one or more physiological signals as part of implementation of the first CRT value optimization process and the one or more additional CRT optimization modules is configured to analyze a second one or more physiological signals as part of implementation of a respective one of the one or more additional CRT value optimization processes, wherein the first one or more physiological signals and the second one or more physiological signals are different signal types.

13. The medical system of claim 11, further comprising a control module, wherein the one or more additional CRT optimization modules are configured to implement multiple of the one or more additional CRT value optimization processes sequentially and the control module is configured to automatically determine an order of implementation of the multiple of the one or more additional CRT optimization processes.

14. The medical system of claim 11, wherein the first CRT value optimization process is different from the one or more additional CRT value optimization processes in that the one or more additional CRT value optimization processes are based on different types of physiological signals with respect to the first CRT value optimization process.

15. The medical system of claim 11, further comprising a user interface, wherein an order of implementation of the one or more additional CRT optimization processes is determined at least in part based on input acquired from a patient-external device.

16. The medical system of claim 11, wherein the processor is configured to combine the first recommended value and at least one additional recommended value returned by the one or more additional CRT optimization modules and to determine the value of the CRT parameter based on the combined recommended values.

17. The medical system of claim 11, wherein at least one component of the medical system is disposed within a housing of an implantable cardiac rhythm management system.

18. The medical system of claim 11, wherein the first CRT value optimization process is different from the one or more additional CRT value optimization processes in that one process is morphology based and the other process is timing based.

19. The medical system of claim 11, wherein the processor is configured to automatically select one recommended value from multiple recommended values returned by multiple of the one or more additional CRT optimization modules as the value of the CRT parameter.

20. The medical system of claim 11, wherein at least one of the CRT optimization modules is selected for implementation based on patient conditions.

21. The medical system of claim 11, wherein the CRT parameter comprises one or more pacing parameters.

22. The medical system of claim 11, further comprising a CRT delivery module configured to deliver the CRT using the determined value of the CRT parameter.

23. A system for determining a value of at least one cardiac resynchronization therapy (CRT) parameter, the system comprising:

means for implementing a first cardiac resynchronization therapy (CRT) optimization process by analyzing one or more physiological signals and returning a first recommended value for at least one CRT parameter;

means for implementing one or more additional CRT optimization processes by analyzing one or more physiological signals to return an additional recommended value for the at least one CRT parameter using a value search range that is adjusted based on the first recommended value for each implementation of the one or more additional CRT optimization processes, the first CRT optimization process based on a different process of optimization with respect to each of the one or more additional CRT optimization processes; and

means for determining the value of the at least one CRT parameter for use in delivery of CRT based on the additional recommended values returned by the one or more additional CRT optimization processes.

24. The system of claim 23, further comprising:

means for acquiring information related to CRT optimization; and

means for selectively implementing at least one of the first and the one or more additional CRT optimization processes based at least in part on the acquired information.

25. The system of claim 23, wherein the means for determining further comprises means for combining the recommended values returned by the one or more additional CRT optimization processes.

26. The system of claim 23, further comprising means for sequentially implementing the one or more additional CRT optimization processes.