Techniques for delivery of stem cell and related therapies to treat cardiac conditions
First Claim
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1. A method comprising:
- acquiring cardiac electrical activity information using at least two electrodes positioned on a surface of a distal end of a lead implanted adjacent cardiac tissue, wherein the lead includes at least one opening through the surface on which the at least two electrodes are positioned, wherein the opening is positioned between the at least two electrodes;
detecting cardiac events within the information including T waves, QRS complexes and P waves;
measuring impedance between two of the electrodes; and
when the impedance measurement indicates the at least one opening is in cardiac tissue, delivering matter to the heart through the at least one opening through the surface on which the at least two electrodes are positioned, wherein the opening is positioned between the at least two electrodes, wherein delivery occurs at a time between a detected T wave and its immediately subsequent QRS complex, andwhen the impedance measurement indicates the at least one opening is not in cardiac tissue, prohibiting the delivery of matter to the heart through the at least one opening;
wherein the measuring and delivering occur repeatedly and incrementally after the detection of the cardiac events.
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Abstract
An exemplary method includes acquiring cardiac electrical activity information; detecting cardiac events within the information including T waves, QRS complexes and/or P waves; and calling for delivery of matter to the heart during a period of time based on the cardiac events. The delivery may occur between a detected T wave and its immediately subsequent QRS complex. The matter being delivered may include stem cells, progenitor cells, nutrients and/or drugs.
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Citations
14 Claims
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1. A method comprising:
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acquiring cardiac electrical activity information using at least two electrodes positioned on a surface of a distal end of a lead implanted adjacent cardiac tissue, wherein the lead includes at least one opening through the surface on which the at least two electrodes are positioned, wherein the opening is positioned between the at least two electrodes; detecting cardiac events within the information including T waves, QRS complexes and P waves; measuring impedance between two of the electrodes; and when the impedance measurement indicates the at least one opening is in cardiac tissue, delivering matter to the heart through the at least one opening through the surface on which the at least two electrodes are positioned, wherein the opening is positioned between the at least two electrodes, wherein delivery occurs at a time between a detected T wave and its immediately subsequent QRS complex, and when the impedance measurement indicates the at least one opening is not in cardiac tissue, prohibiting the delivery of matter to the heart through the at least one opening;
wherein the measuring and delivering occur repeatedly and incrementally after the detection of the cardiac events. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method comprising:
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acquiring cardiac electrical activity information using at least two electrodes positioned on a surface of a distal end of a lead implanted adjacent cardiac tissue, wherein the lead includes at least one opening through the surface on which the at least two electrodes are positioned, wherein the opening is positioned between the at least two electrodes; detecting cardiac events within the information including T waves, QRS complexes and P waves; measuring impedance between two of the electrodes; and when the impedance measurement indicates the at least one opening is in cardiac tissue, delivering matter to the heart through the at least one opening through the surface on which the at least two electrodes are positioned, wherein the opening is positioned between the at least two electrodes, wherein delivery occurs at a time between a detected T wave and its immediately subsequent P wave; and when the impedance measurement indicates the at least one opening is not in cardiac tissue, prohibiting the delivery of matter to the heart through the at least one opening;
wherein the measuring and delivering occur repeatedly and incrementally after the detection of the cardiac events. - View Dependent Claims (14)
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Specification