Stimulator system with electrode array and the method of making the same

• US 8,175,710 B2
• Filed: 03/14/2006
• Issued: 05/08/2012
• Est. Priority Date: 03/14/2006
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: He, Tom Xiaohai
• Primary Examiner(s): KAHELIN, MICHAEL WILLIAM
• Application Number:
  US11/375,638
• Publication Number:
  US 20070219595A1
• Time in Patent Office: 2,247 Days
• Field of Search: 607/36, 607/116, 607/37
• US Class Current: 607/36
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/375 Constructional arrangements, e.g. casings
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

An implantable microstimulator can include a housing with a surface containing a metal region. The housing defines an exterior and an interior. At least one conductive electrode is disposed on the exterior of the housing over the metal region of the housing. Adhesive is disposed between the metal region of the housing and the conductive electrodes. An electronic subassembly is disposed in the interior of the housing and coupled to the conductive electrodes through the housing.

Claims

1. An implantable microstimulator, comprising:

a microstimulator housing comprising an exterior surface with a metal region, the housing defining an exterior and an interior;

a plurality of thin, flat, conductive electrodes each having an exposed broad active surface that is disposed over the metal region of the exterior surface of the housing;

non-conductive adhesive sandwiched between, and in direct contact with, the metal region and each of the plurality of conductive electrodes, the non-conductive adhesive attaching each of the plurality of conductive electrodes to a portion of the metal region with the non-conductive adhesive disposed on top of the exterior surface of the housing and beneath the exposed surface of each of the plurality of conductive electrodes;

an electronic subassembly disposed in the interior of the housing;

at least one conductive via extending from the interior of the housing to a location that is exterior to the housing, the at least one conductive via electrically coupled to the electronic subassembly; and

at least one exterior conductor that is disposed entirely external to the housing, the at least one exterior conductor electrically coupling the conductive via to the plurality of conductive electrodes, wherein at least a portion of the at least one exterior conductor is disposed external to the adhesive;

wherein the plurality of conductive electrodes are configured and arranged to stimulate tissue adjacent to the plurality of conductive electrodes on the housing of the microstimulator when implanted.

2. The implantable microstimulator of claim 1, wherein the at least one exterior conductor comprises a conductor wire.

3. The implantable microstimulator of claim 1, wherein a layer of adhesive between the plurality of conductive electrodes and the metal region of the housing is of a substantially uniform thickness.

4. The implantable microstimulator of claim 1, wherein the adhesive comprises a plurality of spacer particles.

5. The implantable microstimulator of claim 1, wherein the plurality of conductive electrodes are disposed on only one side of the housing.

6. The implantable microstimulator of claim 1, wherein the plurality of conductive electrodes are disposed on each of the at least two opposing sides of the housing.

7. The implantable microstimulator of claim 1, further comprising a battery.

8. The implantable microstimulator of claim 1, wherein the non-conductive adhesive is selected from the group consisting of:

silicones, epoxies, and acrylics.

9. The implantable microstimulator of claim 1, wherein the length of the microstimulator is no greater than 30 mm and the lateral width of a side of the housing is no greater than 5 mm.

10. The implantable microstimulator of claim 1, wherein the exterior surface of the microstimulator housing comprises a non-conductive region, and wherein the at least one conductive via extends from the interior of the housing along the non-conductive region.

11. The implantable microstimulator of claim 1, wherein the broad active surfaces of each of the plurality of conductive electrodes are parallel to the metal region over which the adhesive is attached.

12. The implantable microstimulator of claim 4, wherein the plurality of spacer particles have uniform diameters.

13. The implantable microstimulator of claim 12, wherein the diameters of the plurality of spacer particles are equal to a thickness of the adhesive.

14. A method of making an implantable microstimulator, the method comprising:

disposing an electronic subassembly in a microstimulator housing, the housing comprising an exterior surface with a metal region and defining an exterior and an interior;

attaching a pluralilty of thin, flat, conductive electrodes each having an exposed broad active surface over the metal region of the exterior surface of the housing using a non-conductive adhesive sandwiched between, and in direct contact with, the metal region and each of the plurality of conductive electrodes, wherein the non-conductive adhesive is disposed on top of the exterior surface of the housing and beneath the exposed surface of each of the plurality of conductive electrodes;

electrically coupling the electronic subassembly to at least one conductive via, wherein the conductive via extends from the interior of the housing to a location that is exterior to the housing; and

electrically coupling the at least one conductive via to the plurality of conductive electrodes using at least one exterior conductor that is disposed entirely external to the housing, the at least one exterior conductor electrically coupling the conductive via to the plurality of conductive electrodes, wherein at least a portion of the at least one exterior conductor is disposed external to the adhesive;

wherein the plurality of conductive electrodes are configured and arranged to stimulate tissue adjacent to the plurality of conductive electrodes on the housing of the microstimulator when implanted.

15. The method of making an implantable microstimulator of claim 14, wherein attaching a plurality of thin, flat, conductive electrodes each having an exposed broad active surface over the metal region of the exterior surface of the housing comprises attaching the plurality of conductive electrodes over the metal region of the housing using an adhesive comprising a plurality of spacer particles.

16. The method of making an implantable microstimulator of claim 14, wherein attaching a plurality of thin, flat, conductive electrodes each having an exposed broad active surface over the metal region of the exterior surface of the housing comprises attaching the plurality of conductive electrodes over the metal region of the housing using a layer of adhesive of a substantially uniform thickness.

17. The method of making an implantable microstimulator of claim 14, further comprising:

disposing the plurality of conductive electrodes onto a mold; and

applying adhesive to the plurality of conductive electrodes,

wherein disposing the plurality of conductive electrodes onto a mold and applying adhesive to the plurality of conductive electrodes occur before attaching the plurality of conductive electrodes over the metal region of the housing using the adhesive.

18. The method of making an implantable microstimulator of claim 14, further comprising:

disposing the plurality of conductive electrodes onto a core; and

using the core to form a mold, onto which the plurality of conductive electrodes are transferred.

19. A method of using an implantable microstimulator, comprising:

implanting an implantable microstimulator comprising a microstimulator housing having an exterior surface with a metal region, the housing defining an exterior and an interior;

a plurality of thin, flat, conductive electrodes each having an exposed broad active surface that is disposed over the metal region of the exterior surface of the housing;

non-conductive adhesive sandwiched between, and in direct contact with, the metal region and each of the plurality of conductive electrodes, the non-conductive adhesive attaching each of the plurality of conductive electrodes to a portion of the metal region with the non-conductive adhesive disposed on top of the exterior surface of the housing and beneath the exposed surface of each of the plurality of conductive electrodes;

an electronic subassembly disposed in the interior of the housing;

at least one conductive via extending from the interior of the housing to a location that is exterior to the housing, the at least one conductive via electrically coupled to the electronic subassembly; and

at least one exterior conductor that is disposed entirely external to the housing, the at least one exterior conductor electrically coupling the conductive via to the plurality of conductive electrodes, wherein at least a portion of the at least one exterior conductor is disposed external to the adhesive; and

providing an electrical signal to the plurality of conductive electrodes to stimulate a tissue adjacent to the plurality of conductive electrodes on the housing of the microstimulator.

20. The method of claim 19, wherein providing an electrical signal to the plurality of conductive electrodes to stimulate a tissue comprises providing the electrical signal independently to each of the plurality of conductive electrodes.