Methods for treating a condition or disease associated with cardio-renal function
First Claim
1. A method for treating a human patient with diagnosed hypertension, the method comprising:
- positioning a nerve modulation device in a vicinity of post-ganglionic neural fibers that innervate a kidney of the patient; and
reducing neural communication to and from the kidney with the nerve modulation device,wherein reducing neural communication to and from the kidney significantly improves a measureable physiological parameter associated with the hypertension of the patient,wherein the kidney continues to secrete renin in the patient after reducing neural communication with the nerve modulation device.
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Abstract
Methods and apparatus are provided for treating congestive heart failure, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
937 Citations
22 Claims
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1. A method for treating a human patient with diagnosed hypertension, the method comprising:
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positioning a nerve modulation device in a vicinity of post-ganglionic neural fibers that innervate a kidney of the patient; and reducing neural communication to and from the kidney with the nerve modulation device, wherein reducing neural communication to and from the kidney significantly improves a measureable physiological parameter associated with the hypertension of the patient, wherein the kidney continues to secrete renin in the patient after reducing neural communication with the nerve modulation device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for treating a human patient with diagnosed congestive heart failure, the method comprising:
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positioning a nerve modulation device in a vicinity of post-ganglionic neural fibers that innervate a kidney of the patient; and reducing neural communication to and from the kidney with the nerve modulation device, wherein reducing neural communication to and from the kidney significantly improves a measureable physiological parameter associated with the congestive heart failure of the patient.
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16. A method for treating a human patient with diagnosed chronic renal failure, the method comprising:
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positioning a nerve modulation device in a vicinity of post-ganglionic neural fibers that innervate a kidney of the patient; and reducing neural communication to and from the kidney with the nerve modulation device, wherein reducing neural communication to and from the kidney significantly improves a measureable physiological parameter associated with the chronic renal failure of the patient, wherein the kidney continues to secrete renin in the patient after reducing neural communication with the nerve modulation device.
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17. A method for treating a human patient with diagnosed acute myocardial infarction, the method comprising:
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positioning a nerve modulation device in a vicinity of post-ganglionic neural fibers that innervate a kidney of the patient; and reducing neural communication to and from the kidney with the nerve modulation device, wherein reducing neural communication to and from the kidney significantly improves a measureable physiological parameter associated with the acute myocardial infarction of the patient.
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18. A method for treatment of a human patient via renal denervation, the method comprising:
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positioning a renal denervation catheter having a treatment device in a vicinity of post-ganglionic neural fibers that innervate a kidney of the patient; and reducing neural communication to and from the kidney with the treatment device, wherein reducing neural communication to and from the kidney results in a therapeutically beneficial reduction in blood pressure of the patient. - View Dependent Claims (19, 20, 21, 22)
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Specification