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System and method for stabilizing corneal tissue after treatment

  • US 8,177,778 B2
  • Filed: 10/29/2010
  • Issued: 05/15/2012
  • Est. Priority Date: 10/30/2009
  • Status: Expired due to Fees
First Claim
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1. A system for applying therapy to an eye, the system comprising:

  • an electrical energy source;

    an electrical energy conducting element in contact with the electrical energy source, the electrical energy conducting element having a proximal end configured to receive electrical energy generated by the electrical energy source, and a distal end configured to apply electrical energy;

    a wound healing inhibitor including Mannose 6-phosphate (M6P), the wound healing inhibitor being configured to reduce corneal haze by competing with latent Transforming Growth Factor beta (TGFb) at an Insulin Like Growth Factor II receptor;

    a wound healing inhibitor delivery element in contact with the wound healing inhibitor;

    a processor configured to determine Transforming Growth Factor beta (TGFb) activity,a coolant supply; and

    a coolant delivery element in contact with the coolant supply, the coolant delivery element configured to deliver a pulse of coolantwherein the wound healing inhibitor delivery element is adjusted based on the Transforming Growth Factor beta (TGFb) activity.

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